Comparing two types of plasma exchange for children with sudden liver failure
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether a higher volume of plasma exchange (cleaning the blood to remove toxins) works better than the standard amount for children with acute liver failure who are not improving with usual care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be between 3 and 18 years old.
- Child must have acute liver failure as defined by standard medical criteria (a specific INR level and worsening signs).
- Child's INR (a blood clotting measure) must be 2.5 or higher and still rising, or there must be worsening confusion (hepatic encephalopathy) after 6–12 hours of standard therapy.
- Child must not have disseminated intravascular coagulation (a severe bleeding/clotting disorder).
- Child must not be in septic shock or have severe heart/lung disease.
- Child must not have signs of irreversible brain injury.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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