Comparing two test-guided treatments for acid reflux
Part of Digestive system clinical trials.
This trial compares two ways to choose the best treatment for people with frequent acid reflux. It tests whether using a simple test (called PCAB-guided) is as good as a more detailed test (called physiologic test-guided) for deciding on the right medicine. The goal is to find a more practical and effective approach.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have heartburn, regurgitation, or chest pain from acid reflux at least 4 times a week for more than 4 weeks.
- You do not have complications from GERD like a narrowed esophagus or Barrett's esophagus (a change in the lining of the food pipe).
- You have not taken certain acid-reducing drugs (called PPIs, H2RAs, or PCABs) in the last 2 weeks (or are willing to stop them for 2 weeks before the trial starts).
- You have not taken aspirin, NSAIDs (like ibuprofen), stomach protectants, or other specific medications (like prokinetics or neuromodulators) in the last 4 weeks.
- You are not pregnant or breastfeeding, and you have no known allergies to the study drugs (vonoprazan, omeprazole, or nortriptyline).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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