Clin2
NCT07720193Possibly a fitNot yet recruiting

New drug plus chemotherapy for advanced EP-NEC tumors

Advanced Extrapulmonary Neuroendocrine Carcinoma

Treatments studied

Part of Cancer clinical trials.

This trial tests a new drug (LBL-024) combined with standard chemotherapy for people with advanced EP-NEC, a rare type of neuroendocrine tumor. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
280 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You need to have been diagnosed with a type of neuroendocrine tumor called EP-NEC that is advanced.
  • You should be able to take care of yourself (ECOG score 0 or 1) and have an expected survival of at least 3 months.
  • You must have at least one tumor that can be measured on a scan.
  • If you can have children, you must agree to use effective birth control during the study and for 6 months after.
  • You should not have had major surgery in the last 28 days, have an active infection, or certain heart or brain conditions.
  • You must not have hepatitis B or C, HIV, or be pregnant or breastfeeding.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05058651Recruiting· Phase 2/Phase 3
Atezolizumab plus chemo for advanced neuroendocrine cancer outside the lung

This trial tests whether adding an immunotherapy drug called atezolizumab to standard chemotherapy helps people with advanced neuroendocrine carcinoma (a rare and aggressive cancer) that started outside the lung. The goal is to see if the combination works better than chemo alone.

Anchorage, Alaska
NCT07510594Not yet recruiting· Phase 2
Combination therapy for advanced neuroendocrine cancer

This trial is testing a combination of three drugs (benmelstobart, anlotinib, and chemotherapy) as the first treatment for people with a rare type of cancer called LCNEC or EP-NEC that has spread. The goal is to see if this combination can help shrink or control the cancer and improve outcomes.

Tianjin, Tianjin Municipality
NCT07331155Recruiting· Phase 2
LBL-024 combo for advanced esophageal cancer

This trial tests a new drug combination for advanced solid tumors, specifically esophageal cancer. It may help people whose cancer has not responded to other treatments.

Beijing, Beijing Municipality
NCT07014540Not yet recruiting· Phase 4
Liposomal irinotecan for advanced neuroendocrine carcinoma

This trial tests a new form of the chemotherapy drug irinotecan (called liposomal irinotecan) in people whose advanced neuroendocrine carcinoma has stopped responding to standard first-line treatment. The goal is to see if this special formulation can help slow or shrink the cancer.

Beijing, Beijing Municipality
NCT06157827Recruiting· Phase 1/Phase 2
Testing LBL-024 plus chemo for advanced neuroendocrine carcinoma

This trial tests a new drug, LBL-024, combined with standard chemotherapy (etoposide and platinum) for people with advanced neuroendocrine carcinoma. The goal is to see if this combination works better than chemo alone.

Hefei, Anhui
NCT07738159Not yet recruiting· Phase 2
Immunotherapy plus targeted therapy and chemotherapy for advanced neuroendocrine cancer

This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab), a targeted therapy (lenvatinib), and chemotherapy for people with neuroendocrine carcinoma that has spread or cannot be removed by surgery. The goal is to see if this combination helps shrink tumors and improve outcomes.

Hear when a new Advanced Extrapulmonary Neuroendocrine Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.