Clin2
NCT07752589Possibly a fitNot yet recruiting

Bacteria and immune treatment before surgery for lung cancer

Non-Small Cell Carcinoma of LungGut MicrobiomesNeoadjuvant Chemoimmunotherapy

Part of Cancer, Lungs & breathing clinical trials.

This study tests whether giving a combination of chemotherapy and immunotherapy before surgery can improve outcomes for people with non-small cell lung cancer. Researchers are also studying how the bacteria in your gut (microbiome) affect how well the treatment works. This approach may shrink the tumor and make it easier to remove surgically.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
100 people
Ages
18 years to 80 years
Study type
Observational

Who can take part

  • You must be between 18 and 80 years old.
  • You must have a new diagnosis of non-small cell lung cancer (NSCLC) that has not spread beyond the chest (stage IIA-IIIB) and does not have certain genetic mutations.
  • You must be healthy enough to have surgery to remove the cancer.
  • You must not have had any previous cancer treatment (chemotherapy, radiation, or surgery) for this cancer.
  • You must not be taking oral steroids or other medications that suppress your immune system.
  • You must not have taken antibiotics or probiotics in the past 3 months.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04286841Recruiting
Immunotherapy before lung surgery for early lung cancer

This trial looks at giving immunotherapy before surgery for certain early-stage lung cancers to help shrink the tumor and improve outcomes. It is mainly for people whose lung cancer can be removed by surgery and who don’t have specific gene changes like EGFR or ALK.

Guangzhou, Guangdong
NCT04063501Recruiting
Study of gut microbes during immunotherapy for lung cancer

This trial studies how gut bacteria (the microbiome) and the body’s immune signs change over time while you receive PD-1–based immunotherapy for advanced, unresectable non–small cell lung cancer. The goal is to learn which immune and microbial patterns might relate to how well treatment works and how patients respond.

New York, New York
NCT07119190Not yet recruiting
Immunotherapy before and after lung cancer surgery

This study looks at a treatment plan that uses immunotherapy before and after surgery for non-small cell lung cancer. The goal is to see if this approach helps patients do better and to find out which patients benefit most.

NCT06317558Recruiting
Real-world study of immunotherapy before surgery for lung cancer

This study looks at how well immunotherapy given before surgery works for non-small cell lung cancer. It aims to help doctors understand real-world outcomes for patients who receive this treatment.

Beijing, Beijing Municipality
NCT07166003Recruiting
Immunotherapy before surgery for lung cancer

This trial tests whether giving immunotherapy before surgery helps people with lung cancer. It is for patients who have already started this treatment and are otherwise healthy.

Beijing
NCT06962189Not yet recruiting· Phase 2
Immunotherapy and chemo before surgery for advanced lung cancer

This study tests a combination of an immunotherapy drug (sintilimab) and chemotherapy to see if it can shrink advanced lung cancer enough to make surgery possible. The goal is to improve outcomes for people whose cancer is currently too extensive for surgery.

Hear when a new Neoadjuvant Chemoimmunotherapy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.