Mazdutide for type 2 diabetes remission
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests a new medication (mazdutide) to see if it can help people with type 2 diabetes achieve remission (normal blood sugar levels without needing diabetes medications). It is for adults with type 2 diabetes who are not well controlled on their current treatment (which can be diet and exercise alone, or metformin or an SGLT2 inhibitor). The study will last for a period of time, and participants will receive either the study drug or a placebo (inactive substance).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 70 years old.
- You must have been diagnosed with type 2 diabetes for 5 years or less.
- Your diabetes should be managed with diet and exercise alone, or with stable doses of metformin or an SGLT2 inhibitor (e.g., empagliflozin, dapagliflozin, canagliflozin) for at least 4 weeks.
- Your HbA1c (a measure of average blood sugar over 3 months) must be between 6.5% and 9.0%.
- Your body mass index (BMI) must be 24 kg/m² or higher.
- You must NOT have used certain other diabetes medications (like GLP-1 receptor agonists) in the last 2 months.
- You must NOT have used insulin in the last 3 months (except for short-term use during illness or surgery).
- You must NOT have taken weight-loss medications in the last month.
- You must not have any of the following: type 1 diabetes, pancreatitis, severe heart or blood vessel disease, uncontrolled high blood pressure, liver or kidney problems, or a history of certain thyroid conditions.
- You must not be pregnant, planning pregnancy, or breastfeeding during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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