Osteoporosis treatment study for hip bone density
Treatments studied
Part of Bones, joints & muscles, Hormones & metabolism clinical trials.
This study compares two treatment plans for women with osteoporosis to see which one improves hip bone density more. Participants will either get two medications in sequence (romosozumab followed by denosumab) or one medication (zoledronic acid), both given as injections or infusions. The goal is to find a treatment that reduces fracture risk.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman aged 60 or older and have gone through menopause.
- You have osteoporosis, confirmed by a bone density test (T-score of -2.5 or lower).
- You have had a broken bone after age 50 from a minor fall or similar, or you are at high risk of breaking a bone based on a standard risk calculator.
- Your kidney function is good enough for the study medications, and your calcium and vitamin D levels are within normal range.
- You have not recently used certain osteoporosis medications (like bisphosphonates or denosumab) and have never used romosozumab.
- You have not had a heart attack or stroke in the past, and you do not have severe osteoporosis or certain heart conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a combination of two medications, romosozumab and denosumab, can improve bone strength better than standard care for women after menopause who have osteoporosis and have had multiple fractures. The goal is to see if this combined approach reduces the risk of future breaks.
This trial is testing a medicine called romosozumab to treat postmenopausal women with severe osteoporosis and a recent fracture. It aims to find the best way to use this drug to strengthen bones and prevent more fractures.
This study tests whether denosumab, a medication that strengthens bones, can also improve muscle strength and insulin sensitivity in postmenopausal women with type 2 diabetes who take metformin.
This trial compares two osteoporosis drugs (romosozumab and denosumab) given alone or together to see which works better for improving bone density. It may help if you are a postmenopausal woman with osteoporosis and have not taken strong bone medications recently.
This trial tests whether switching between two medications (Romosozumab and Denosumab) using a cycle or sequence schedule works better for improving bone density in postmenopausal women with severe osteoporosis. It aims to find the most effective treatment plan.
This study looks at what changes in the body after starting romosozumab (an osteoporosis treatment) in postmenopausal women at higher risk for fractures. Researchers want to understand the treatment’s “mechanism,” which may help improve future osteoporosis care.
Hear when a new Osteoporosis in Post-menopausal Women trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.