Stem cell infusion for early menopause
Part of Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial tests whether a single infusion of stem cells made from human umbilical cord tissue can help women with premature ovarian insufficiency (early menopause) by improving ovarian function and reducing menopause symptoms. Participants will continue their usual hormone replacement therapy during the study.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 40 years old.
- You have been diagnosed with premature ovarian insufficiency (early menopause), meaning your periods are very irregular or absent for more than 4 months, and your FSH (follicle-stimulating hormone) level is above 25 U/L on two tests taken at least 4 weeks apart.
- You have either fewer than 5 antral follicles (small follicles) in both ovaries combined, or your AMH (anti-Müllerian hormone) level is very low (≤7.85 pmol/L).
- You have been on a stable dose of hormone replacement therapy (HRT) for at least 3 months and are willing to continue it throughout the study.
- You do not plan to become pregnant and are willing to use effective contraception during the trial.
- You have a negative pregnancy test and are not breastfeeding.
- You have not had cancer, and you do not have certain other medical conditions (like thyroid problems, abnormal chromosomes, or severe liver/kidney disease).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial uses your own fat cells (called stromal vascular fraction) to try to improve ovarian function and help you become pregnant if you have premature ovarian insufficiency. It may help restore your egg supply and menstrual cycles.
This study tests whether stem cells from the fluid around a baby (amniotic membrane) can help women with premature ovarian insufficiency improve their chances of getting pregnant. It is designed for women under 40 who have not had a period for months and have high FSH levels.
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
This trial tests whether injecting your own bone marrow cells can help reverse early menopause (premature ovarian insufficiency). It's for people who have not responded to standard hormone therapy.
This trial tests if a hormone injection (HCG) can activate dormant eggs in the ovaries of women under 40 who have very irregular periods and high FSH levels. It may offer a new option for those with early ovarian aging.
This study tests whether umbilical cord stem cells can help restore ovarian function in women with primary ovarian insufficiency (POI)—a condition where the ovaries stop working too early. Participants will receive stem cell injections while continuing their current hormone therapy.
Hear when a new Premature Ovarian Insufficiency trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.