Clinical trials
Premature Ovarian Insufficiency clinical trials
Below are recruiting premature ovarian insufficiency clinical trials, each written for real people, not researchers. We’re tracking 17 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07509840RecruitingPhase 3
Immune therapy to restore ovary function and fertility
This trial tests whether an immune-modulating drug can restart ovulation and improve fertility in women whose ovaries stopped working due to autoimmune disease. It is for women ages 18–38 with autoimmune premature ovarian insufficiency and certain antibodies.
StockholmAges 18–38 - NCT04167033Recruiting
Checking heart rhythm timing in women with premature ovarian insufficiency
This study measures how quickly the heart “recharges” between beats (often shown as QT timing). It compares women with premature ovarian insufficiency to healthy women to understand whether ovarian insufficiency is linked to heart rhythm differences.
BordeauxAges 18–40 - NCT04948658Recruiting
Freezing ovarian tissue to protect future fertility
This study looks at storing ovarian (ovary) tissue by freezing it for people at higher risk of losing fertility. It may help preserve options for having biological children later, especially for certain genetic conditions, cancer-related risks, or planned gonad removal.
Bethesda, MarylandAges 2–35 - NCT05858307Recruiting
Testing AMH blood levels for PCOS and POI patients
This study looks at how a blood test called AMH (anti-Müllerian hormone) is used in people being seen for PCOS or POI (early ovarian failure). The goal is to understand whether AMH measurements are useful for care in clinics and fertility treatment settings.
Hong KongAges 10–44 - NCT06067529Recruiting
Study on the health effects of early menopause
This study follows women with premature ovarian insufficiency (POI) over time to understand how it affects their health. Researchers will collect samples and track health changes to learn more about the condition and its long-term effects.
Hangzhou, ZhejiangAges 10–65 - NCT06096766Recruiting
Ovarian function and blood markers study
This study looks at how certain blood markers relate to ovarian function in women with normal ovaries, diminished ovarian reserve (DOR), or primary ovarian insufficiency (POI). It may help doctors better understand these conditions.
BeijingAges 18–45 - NCT06302543Recruiting
Bone Marrow Cells for Early Menopause
This trial tests whether injecting your own bone marrow cells can help reverse early menopause (premature ovarian insufficiency). It's for people who have not responded to standard hormone therapy.
BaghdadAges 30–60 - NCT06339489Recruiting
Bone Health in Early Menopause Study
This study looks at how bone health changes in women with premature ovarian insufficiency (early menopause). It aims to understand the body's bone metabolism to help manage long-term health.
BeijingAges 18–39 - NCT06481969Recruiting
Fat cell therapy for premature ovarian failure
This trial uses your own fat cells (called stromal vascular fraction) to try to improve ovarian function and help you become pregnant if you have premature ovarian insufficiency. It may help restore your egg supply and menstrual cycles.
Beijing, Beijing MunicipalityAges 20–39 - NCT06645379Recruiting
Platelet-rich plasma for fertility treatments
This trial tests whether injecting platelet-rich plasma (a concentrate from your own blood) into the uterus or ovaries can help women with certain fertility issues, such as damaged uterine lining, scarring, or low egg reserve. It aims to improve pregnancy chances in these challenging cases.
Yiwu, ZhejiangAges 18–50 - NCT06851754RecruitingPhase 3
Hormone therapy for teens with early menopause
This trial tests whether hormone replacement therapy (HRT) helps protect bone health in teenagers with premature ovarian insufficiency (POI). It compares HRT to a placebo and also includes healthy volunteers for comparison.
Bethesda, MarylandAges 11–19 - NCT07115082RecruitingPhase 1/Phase 2
Stem cells from amniotic fluid for early menopause
This study tests whether stem cells from the fluid around a baby (amniotic membrane) can help women with premature ovarian insufficiency improve their chances of getting pregnant. It is designed for women under 40 who have not had a period for months and have high FSH levels.
ShanghaiAges 20–40 - NCT07511660Enrolling by invitation
Ovarian cell injection for perimenopause symptom relief
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
Monterrey, Nuevo LeónAges 28–70 - NCT07775391RecruitingPhase 1/Phase 2
Stem cell infusion for early menopause
This trial tests whether a single infusion of stem cells made from human umbilical cord tissue can help women with premature ovarian insufficiency (early menopause) by improving ovarian function and reducing menopause symptoms. Participants will continue their usual hormone replacement therapy during the study.
Beijing, Beijing MunicipalityAges 18–40 - NCT02846064Recruiting
Ovarian tissue graft to restore ovarian function
This study looks at using your own frozen ovarian tissue that was saved earlier, then grafting it back to help restart normal ovarian function. It may be an option for people with premature ovarian failure who have been treated for their original cancer/illness.
BesançonAges 18–43 - NCT04390308Recruiting
Testing gentle stimulation of ovaries before fertility treatment
This trial studies whether a “mechanical stimulation” procedure can help small egg-making structures in the ovary start to work again in people with primary ovarian insufficiency. If the procedure shows signs of response, you may then move on to further fertility treatment, including IVF.
Abu Dhabi, Abu Dhabi EmirateAges 18–40 - NCT02855827Recruiting
Monitoring patients who may receive ovarian tissue back
This study follows people who have saved their own ovarian tissue (cryopreserved tissue) and may receive it back to try to restore ovarian function. It’s mainly for people with premature ovarian insufficiency and plans for tissue autograft, with monitoring for safety and outcomes.
BesançonAges 11–43
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Common questions
- Are there clinical trials for premature ovarian insufficiency?
- Yes. Clin2 currently lists 17 recruiting premature ovarian insufficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a premature ovarian insufficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a premature ovarian insufficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.