New drug combo for aggressive lymphoma
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new combination of drugs for people newly diagnosed with an aggressive type of lymphoma called diffuse large B-cell lymphoma (DLBCL). The combo includes orelabrutinib plus standard chemo-immunotherapy, and may help improve outcomes for those at intermediate or high risk.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You must have a confirmed diagnosis of diffuse large B-cell lymphoma (DLBCL) with at least one measurable tumor.
- You must not have received any previous treatment for your lymphoma.
- You should be generally able to care for yourself (ECOG score 0-2).
- Your lymphoma must be at an intermediate or high risk level, with an IPI score of 2 to 5, and be in stage III or IV.
- You must be expected to live at least 6 more months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding orelabrutinib (a targeted pill) to standard chemotherapy, with or without a stem cell transplant, works better for people with a new diagnosis of diffuse large B-cell lymphoma. It may help patients who have a higher risk of the lymphoma coming back.
This trial tests a new targeted drug (orelabrutinib) combined with standard therapy for people with a specific genetic type of DLBCL called MCD subtype. After initial treatment, you would continue on the targeted drug alone to help prevent the cancer from coming back.
This trial tests a combination of targeted therapy (Orelabrutinib) plus standard chemotherapy (Pola-R-CHP) for people with untreated non-GCB diffuse large B-cell lymphoma. The goal is to see if this new mix works better than the usual treatment.
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This trial tests combining a targeted drug (orelabrutinib) with standard chemo (R-CHOP plus methotrexate or thiotepa) for people whose DLBCL has spread to the brain or spinal cord. The goal is to see if this combination works better against hard-to-treat lymphoma.
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