Comparing nonsurgical treatments for chronic ankle pain
Part of Bones, joints & muscles, Pain clinical trials.
This trial compares three minimally invasive procedures—radiofrequency, hydrodissection, and cryoneurolysis—to see which best relieves chronic ankle pain after a ligament injury. It may help if you are an athlete with ongoing ankle pain that has not improved with other treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an athlete between 18 and 45 years old.
- You have had ankle pain for more than 6 months after an injury to the anterior talofibular ligament (a ligament in your ankle).
- Your doctor has confirmed the ligament injury through imaging, such as an MRI or ultrasound.
- You have tried conservative treatments (like physical therapy or pain medication) without success.
- You have not had surgery on your ankle and do not need surgery now.
- You do not have nerve problems, diabetes-related nerve damage, or other neurological conditions.
- You are not allergic to botulinum toxin, and you don't have any reason to avoid the study procedures.
- You have not had the ankle pain for more than 5 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two treatments for long-term heel pain: a newer procedure using heat (radiofrequency) and a traditional steroid injection. The goal is to see which provides better pain relief with fewer side effects.
This trial studies a pain-control approach (a kind of nerve block) to see if it can reduce pain after surgery for certain ankle fractures. It may help you feel more comfortable while your ankle heals after an operation.
This trial compares two methods to control bleeding during ankle surgery. One uses a diluted medicine to constrict blood vessels, the other uses a tourniquet. The goal is to see which method gives the surgeon a clearer view.
This trial compares two surgical techniques to fix chronic ankle instability. It is for people with ongoing ankle weakness, multiple sprains, or loose ligaments who have not had ankle surgery before.
This study compares two non-surgical treatments for chronic ankle instability, which is long-term ankle weakness or pain after a sprain. One treatment uses sound waves to stimulate healing, and the other uses targeted light therapy. The goal is to see which one better reduces pain and improves ankle function.
This study tests whether a numbing injection around the ankle nerves before surgery can reduce pain and help you recover faster after ankle arthroscopy. It is for people having this keyhole surgery and staying in the hospital for a short time.
Hear when a new Chronic Ankle Pain in Athletes trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.