Lowering semaglutide dose to maintain weight loss
Part of Hormones & metabolism clinical trials.
This study tests whether gradually lowering the dose of the weight-loss drug semaglutide can help people who have already lost weight keep it off. You may join if you are already taking weekly semaglutide and have lost at least 10% of your starting weight or are at a healthy weight after losing 5%.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 64 years old.
- You are currently taking weekly semaglutide and have lost at least 10% of your starting weight (or at least 5% if your weight is now in the healthy range).
- Your weight has stayed about the same (<5% change) for the last 3 months while taking a 1.7 mg dose.
- You have not had weight-loss surgery and do not plan to during the study.
- You do not have diabetes (or a history of it) and your blood sugar test (HbA1c) is below 6.5%.
- You have not used other weight-loss drugs, supplements, or meal replacements in the past 90 days (semaglutide is okay).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a small implant placed under the skin that slowly releases semaglutide, a medication that helps with weight management. It's for people who are overweight but do not have diabetes.
This study tests whether a low dose of semaglutide (a once-weekly injection) can help obese adults without diabetes lose weight. Semaglutide works by reducing appetite and helping your body use food differently.
This study tracks how semaglutide (an injectable medication that reduces appetite) helps adults lose weight in everyday life. Researchers want to understand how well it works and how safe it is for people starting the treatment.
This study tests a medication called semaglutide (which helps with weight loss) in people with obesity who have struggled to lose weight before. It will see how much weight participants can lose while taking the drug.
This study tests an injectable medication called semaglutide to help with weight loss in people with a BMI of 28 or higher who have struggled to lose weight before. It compares the study drug to a similar approved weight loss medicine (Wegovy).
This study looks at what happens to your body and weight when you stop taking semaglutide (Wegovy/Ozempic) after losing at least 10% of your starting weight. The goal is to understand how your metabolism and heart health change once the medication is paused.
Hear when a new Obesity & Overweight trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.