Study of NXP900 with lorlatinib for ALK-positive lung cancer
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This study tests a new drug called NXP900 in combination with lorlatinib for people with ALK-positive lung cancer who have already been treated with lorlatinib and tolerated it well. The goal is to see if this combination is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have ALK-positive non-small cell lung cancer (NSCLC) that is advanced (unresectable, metastatic, or locally advanced).
- You must have previously taken lorlatinib as your first or second line of targeted therapy.
- You must have tolerated the dose of lorlatinib you took (or a higher dose) without severe side effects.
- You must not have known resistance mutations to lorlatinib or other targetable mutations (like MET, EGFR, or HER2) with approved therapies.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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