Clin2
NCT07790549Possibly a fitNot yet recruiting

Add-on gel for acid reflux without esophageal damage

Non-Erosive Gastroesophageal Reflux Disease (NERD)

Treatments studied

Part of Digestive system clinical trials.

This study tests an add-on gel called Mirgeal® that you take along with the usual acid-reducer esomeprazole (Nexium) to see if it improves symptom relief for people with non-erosive acid reflux (NERD) — reflux that doesn't show visible damage on an endoscopy. It may help reduce heartburn and acid regurgitation.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
140 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You have a diagnosis of non-erosive reflux disease (NERD), which means an endoscopy in the last 6 months showed no visible damage to your esophagus.
  • You have heartburn or acid coming back up at least 3 times a week for the 2 weeks before the study starts.
  • You must not have taken heartburn medications (like proton pump inhibitors, H2 blockers, or steroid pills) in the 2 weeks before the study.
  • You are not pregnant or breastfeeding, and you do not have severe kidney or liver problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07624383Recruiting
New topical treatment for nonerosive acid reflux disease

This study tests a new topical treatment for people with chronic heartburn and acid regurgitation who don't have erosions (damage) in their esophagus. The treatment is applied directly to the affected area and may help relieve symptoms without taking daily pills.

Warsaw, Masovian Voivodeship
NCT07700342Recruiting
Could an evening gel improve sleep for nighttime reflux?

This trial tests a topical therapy you apply at night to see if it can improve sleep for people with non-erosive GERD who still have nighttime symptoms even while taking a morning acid reducer.

Warsaw, Masovian Voivodeship
NCT07160790Not yet recruiting· Phase 3
New treatment for acid reflux without esophageal damage

This study tests an investigational medication called JP-1366 for people with non-erosive GERD, a condition where acid reflux causes heartburn and regurgitation but no visible damage to the esophagus. The goal is to see if this new treatment can safely reduce symptoms better than a placebo.

NCT06106100Not yet recruiting
Endoscopic treatment for ongoing acid reflux symptoms

This trial tests a new endoscopic procedure called anti-reflux mucosal ablation therapy to reduce acid reflux in people who still have symptoms despite taking acid-reducing medication. The goal is to see if this treatment helps improve heartburn and related symptoms.

NCT06953986Recruiting
Comparing three medicines for severe acid reflux healing

This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.

Hyderabad, Telangana
NCT04255693Recruiting
Real-life reflux study of diet and behavior changes

This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.

Moscow

Hear when a new Non-Erosive Gastroesophageal Reflux Disease (NERD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.