Dosing busulfan by body size in children before bone marrow transplant
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new way to calculate the dose of the chemotherapy drug busulfan based on a child's body surface area, before a bone marrow transplant. The goal is to make dosing more accurate and possibly improve safety and effectiveness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 21 years old or younger
- You have a planned bone marrow transplant that includes busulfan as part of the conditioning regimen
- You will have blood tests to check busulfan levels after the first dose
- You have a body surface area (a measure of body size) that fits into one of two groups (either at least 0.5 square meters or less than 0.5 square meters)
- Any diagnosis that requires a bone marrow transplant is acceptable
- If you have taken certain medications (like deferasirox, metronidazole, ketoconazole, voriconazole, itraconazole, posaconazole, or phenytoin), you must have stopped them for a specific washout period before starting
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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