Penicillin to prevent rheumatic heart disease in children
Part of Heart & circulation, Infections clinical trials.
This study tests whether giving penicillin to healthy school-aged children for a few years can prevent rheumatic heart disease, a serious heart condition that can start after a strep throat infection. If your child qualifies, they would receive free heart checks and treatment that could keep their heart healthy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child is between 5 and 8 years old when they join.
- Your family lives in Gulu District or Gulu City.
- Your child has a normal heart ultrasound (echocardiogram) at the start.
- Your child has never had rheumatic fever or rheumatic heart disease.
- Your child is not allergic to penicillin, and has no other health conditions that require regular antibiotics.
- You and your child are willing to be part of the study for about 3 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study checks children aged 5–8 for early signs of rheumatic heart disease, a heart problem that can follow a strep throat infection. It aims to see how common it is in different parts of Africa to help prepare for a future vaccine. Children with a normal heart ultrasound at the start may join.
This study tests whether a program in schools can help prevent rheumatic heart disease in children. If your child is between 5 and 16 years old and attends a participating school, they may be able to join.
This trial tests different treatments for acute rheumatic fever with heart inflammation (carditis) to see if they can reduce damage to the heart valves after 6 months. It aims to find better ways to prevent long-term rheumatic heart disease.
This study tests whether a prevention program done at a specific school can reduce how common “latent” (hidden) rheumatic heart disease is in children. If you attend the study’s school in Tulsipur, this program may be offered to help protect students’ heart health over time.
This study tests a new vaccine called StreptInCor that may help prevent rheumatic fever (a condition caused by strep infections that can damage the heart). It is an early trial to check if the vaccine is safe and produces a good immune response in healthy adults.
This study tests ways to help people with rheumatic heart disease stick to their daily antibiotic routine, which can prevent further heart damage. It also includes their families and healthcare workers to see what support works best.
Hear when a new Rheumatic Heart Disease in Children trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.