Treatments for acute rheumatic fever and heart inflammation
Treatments studied
Part of Bones, joints & muscles, Heart & circulation, Infections, Skin clinical trials.
This trial tests different treatments for acute rheumatic fever with heart inflammation (carditis) to see if they can reduce damage to the heart valves after 6 months. It aims to find better ways to prevent long-term rheumatic heart disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 4 and 25 years old.
- You are currently in the hospital with a diagnosis of acute rheumatic fever (definite or possible).
- An echocardiogram (ultrasound of the heart) has confirmed inflammation of your heart valves (valvulitis).
- You have not had heart surgery or a procedure for rheumatic heart disease in the last 6 months.
- You are able to attend follow-up visits for 6 months after joining the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving penicillin to healthy school-aged children for a few years can prevent rheumatic heart disease, a serious heart condition that can start after a strep throat infection. If your child qualifies, they would receive free heart checks and treatment that could keep their heart healthy.
This study tests whether the antibiotic azithromycin can help prevent further heart damage in young people with mild or moderate rheumatic heart disease (a condition caused by rheumatic fever that affects the heart valves). Participants will receive study medication and regular check-ups to see if it helps keep their heart healthy.
This study checks children aged 5–8 for early signs of rheumatic heart disease, a heart problem that can follow a strep throat infection. It aims to see how common it is in different parts of Africa to help prepare for a future vaccine. Children with a normal heart ultrasound at the start may join.
This study tests ways to help people with rheumatic heart disease stick to their daily antibiotic routine, which can prevent further heart damage. It also includes their families and healthcare workers to see what support works best.
This study looks at whether building a better, sustainable cardiac surgery service can reduce the burden of rheumatic heart disease. It focuses on patients who need cardiac surgery at a specific hospital during a training and research program.
This study uses fun, educational activities to help school children learn about rheumatic fever and rheumatic heart disease, which affect the heart after untreated throat infections. It will see if these activities improve students' knowledge and awareness.
Hear when a new Rheumatic Heart Disease in Children trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.