Brain imaging study for people with opioid use disorder
Part of Mental health clinical trials.
This study uses a special brain scan (PET) and MRI to look at how a protein in the brain, called CB1 (part of the body's natural pain and reward system), changes when people start treatment for opioid use disorder. It may help doctors understand how buprenorphine works and improve addiction treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be an adult (though the trial doesn't say a specific age, it's a typical requirement) in generally good physical health.
- You must be able to have blood drawn and an arterial line placed (a tiny tube in your wrist or groin to collect blood samples).
- You must not have any metal in your body (like a pacemaker or certain implants) that would prevent an MRI (a safe imaging scan).
- If you have opioid use disorder, you must be diagnosed according to standard criteria, be actively seeking treatment, and be willing to start a medication called buprenorphine.
- If you are a healthy volunteer, you must have no current or past psychiatric or substance use disorders (nicotine use is allowed).
- You must not have used any substances (including opioids, alcohol, or other drugs) in the past 30 days, and you must not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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