Bladder-sparing drug combo for muscle-invasive bladder cancer
Treatments studied
Part of Cancer, Kidney & urinary clinical trials.
This study tests two drugs, enfortumab vedotin and pembrolizumab, to see if they can help people with muscle-invasive bladder cancer avoid removing their bladder. The drugs are given before the standard surgery to possibly shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have muscle-invasive bladder cancer that has not spread to other parts of the body.
- Your tumor is mostly urothelial (the type of cell lining the bladder) and does not contain certain rare types.
- You are healthy enough for bladder removal surgery (cystectomy).
- You have a recent bladder tumor biopsy or sample that can be tested.
- You have not had previous treatments for advanced bladder cancer, and you haven't had radiation to the bladder.
- You do not have uncontrolled diabetes, active autoimmune disease, or certain eye or lung conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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