Testing an anti-inflammatory drug with Lexapro for depression
Part of Mental health clinical trials.
This study tests whether an anti-inflammatory medication (adalimumab, also known as Humira) can help treat depression when added to Lexapro. It may help people whose depression is linked to higher levels of inflammation in the body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with major depressive disorder.
- You are already taking Lexapro (escitalopram) at a steady dose for at least 4 weeks.
- Your blood shows a higher than normal level of TNF-alpha (a marker of inflammation) — you'll need a blood test to confirm.
- You are not pregnant or breastfeeding, and if you could become pregnant, you're using effective birth control.
- You don't have conditions like cancer, HIV, hepatitis, active infections, or autoimmune diseases, and you're not taking immune-suppressing medications.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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