Switching to a new treatment for weight or diabetes
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests a new medicine called zenagamtide for adults with overweight or obesity, with or without type 2 diabetes, who are currently taking semaglutide. The goal is to see how well people tolerate switching from semaglutide to the new treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have been taking a stable dose of semaglutide (like Ozempic or Wegovy) for at least 4 weeks
- If you have type 2 diabetes, your blood sugar is not too high (HbA1c less than 10.5%) and you are on stable diabetes pills (metformin or SGLT2 inhibitors) for at least 90 days
- You are not pregnant, breastfeeding, or planning to become pregnant, and if you could become pregnant, you use effective birth control
- You do not have certain stomach or intestinal conditions that cause symptoms like nausea or diarrhea
- You have not reduced your semaglutide dose due to side effects
- You are not currently taking other prescription or over-the-counter medications (with some exceptions like statins or blood pressure meds)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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