Clinical trials
Arthritis Knee clinical trials
Below are recruiting arthritis knee clinical trials, each written for real people, not researchers. We’re tracking 84 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05020028RecruitingPhase 2/Phase 3
CBD to reduce knee pain from osteoarthritis
This study tests cannabidiol (CBD) to help lower pain from knee osteoarthritis. It may be an option if you have ongoing knee pain and meet age, safety, and medication guidelines.
New York, New YorkAges 40–75 - NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT07575425Recruiting
Balance Platform Exercises for Knee Osteoarthritis
This study tests whether special balance exercises on a moving platform can improve steadiness and walking in people with moderate knee osteoarthritis. The goal is to see if this type of training helps reduce pain and improve mobility.
AnkaraAges 45–65 - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT06485843RecruitingPhase 2
Testing a new injection for moderate to severe knee osteoarthritis
This study tests the safety of an experimental injection called OA-SYS for people with moderate to severe knee osteoarthritis. It may help if you have not had recent injections or certain other health problems.
Las Vegas, NevadaAges 35–75 - NCT07397806Recruiting
Home-based leg trainer for knee osteoarthritis
This study tests a home exercise device designed to improve leg control and reduce pain in people with knee osteoarthritis. You may be eligible if you have knee pain and are between 40 and 85 years old.
Vail, ColoradoAges 40–85 - NCT07361198Recruiting
Knee artery embolization for arthritis pain
This trial tests a minimally invasive procedure to block small blood vessels in the knee, which may reduce pain from osteoarthritis. It's for people with ongoing knee pain even after standard treatments like medication or physical therapy.
Ústí nad LabemAges 40–80 - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT07264296Enrolling by invitation
Infection after bone cancer surgery with a big joint implant
This trial studies infections that happen after surgery for bone cancer where a large artificial joint is placed. It aims to understand why some patients get infections, which may lead to better prevention or treatment.
GothenburgAges Any age - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT07473232Recruiting
Comparing platelet-rich plasma and cytokine-rich serum injections for knee osteoarthritis
This trial compares two types of injections (PRP and ACS) to see which one works better for knee osteoarthritis. It may help people with knee pain who have not had these injections recently.
Pamukkale, DenizliAges 40–80 - NCT07424352Recruiting
Rotational exercise for knee osteoarthritis
This study tests a special rotational exercise device to see if it can improve knee function and reduce pain in people with knee osteoarthritis. It involves supervised sessions at the university and may help you move better without surgery.
Aurora, ColoradoAges 40–70 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT05302934Recruiting
Testing a knee-surgery app and sensor after knee replacement
This trial checks whether a data platform that uses a wearable sensor and a phone app works well for people getting a total knee replacement. It may help make follow-up care more organized and easier by capturing recovery information.
Konstanz, Baden-WurttembergAges 18 years+ - NCT07423858Recruiting
E-coach for hip and knee arthritis advice
This study tests a digital coach that gives you personalized advice to manage your hip or knee arthritis. It aims to help you get the right guidance at the right time.
UtrechtAges 45 years+ - NCT07551245Recruiting
High-intensity laser vs traditional treatment for knee osteoarthritis
This study tests whether high-intensity laser therapy works better than traditional physical therapy methods for knee osteoarthritis pain and function. You'll be randomly assigned to receive either laser treatments or standard rehabilitation exercises.
Erbil, Erbil GovernorateAges 30–60 - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT06249906Recruiting
Bioceramic material for bone defect repair
This trial tests a new bioceramic material to repair bone defects. It is for adults aged 18 to 65 who are generally healthy and can follow the study plan.
Nanjing, JiangsuAges 18–65 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99
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Common questions
- Are there clinical trials for arthritis knee?
- Yes. Clin2 currently lists 84 recruiting arthritis knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthritis knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthritis knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.