Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 225 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04230616Recruiting
Testing a knee device to ease osteoarthritis pain
This study tests how well and how safely a knee treatment works for adults with painful knee osteoarthritis seen on X-ray. You might join if you need meaningful pain relief and help with daily function, and can complete required scans and study instructions.
Sint-Truiden, LimburgAges 18 years+ - NCT04960098Recruiting
Survey after hip or knee replacement surgery
This study asks people who have had a hip or knee replacement to share how they’re doing over time. It’s testing whether patient-reported survey answers can help measure recovery and outcomes.
MilanAges 18 years+ - NCT04247672Recruiting
Study of knee replacement outcomes using a specific knee implant
This study follows people who need knee replacement for “end-stage” knee osteoarthritis and will receive a specific knee implant system as part of routine care. It aims to measure how well the knee replacement works for patients over time, which may help improve future care.
Hoofddorp, North HollandAges 21–90 - NCT04226339Recruiting
Test walking analysis after knee replacement, different alignment methods
This study compares two ways of aligning the knee during a total knee replacement and checks how people walk afterward using a walking test. It may help doctors choose the alignment method that best supports safer, smoother walking.
LyonAges 55–80 - NCT05892133Recruiting
Exercise program before knee replacement to improve recovery
This trial studies whether doing a structured exercise or “prehab” program before total knee replacement can improve knee function and patient satisfaction after surgery. It may help you recover better and feel more confident in your outcome.
Molde, Møre og RomsdalAges 50–80 - NCT07869615Recruiting
Blood thinners after knee replacement surgery
This study compares two types of blood thinners to prevent blood clots after knee replacement surgery. It will help find which one works better and is safer for patients.
Tunis, Tunis GovernorateAges 18–80 - NCT07864896RecruitingPhase 3
Study of a new pain medicine after knee replacement surgery
This trial tests a new oral pain medicine called suzetrigine for people who have a knee replacement. It aims to see if it helps control pain after surgery better or with fewer side effects than usual care.
New York, New YorkAges 18–80 - NCT06108063RecruitingPhase 1/Phase 2
Losartan to prevent knee stiffness after replacement
This study tests whether losartan, a blood pressure medicine, can prevent excessive scar tissue (arthrofibrosis) after a total knee replacement. Participants receive losartan or a placebo for 6 months after surgery to see if it improves knee motion and reduces stiffness.
Vail, ColoradoAges 18 years+ - NCT04801654Recruiting
Knee replacement study using a specific metal implant coating
This study looks at outcomes after a primary knee replacement using the GMK Sphere TiNb implant. It may help researchers learn how well this specific implant works and how patients do over time.
Milan, MIAges 18 years+ - NCT07848126Recruiting
Foam rolling after knee replacement surgery
This study tests whether using a foam roller after knee replacement surgery helps reduce pain and improve movement. If you are having your first knee replacement, this may help you recover faster.
Izmir, BalçovaAges 40 years+ - NCT07840391Recruiting
Recovery after same-day knee replacement surgery
This study looks at how your physical activity, sleep, and knee function change after you go home the same day as your knee replacement surgery. It aims to help you recover better by understanding these factors.
TampereAges Up to 80 years - NCT07838012Recruiting
Early home cycling after knee replacement surgery
This study tests whether starting gentle cycling at home soon after knee replacement surgery is safe and helpful. It aims to see if patients can use a stationary bike to speed up recovery.
Silkeborg, Central JutlandAges 18 years+ - NCT05516381Recruiting
Navigation-assisted knee replacement with two alignment methods
This study tests a computer-guided technique for total knee replacement and compares two ways of aligning the new joint. It may help improve how accurately the surgery is done, which could affect comfort and function afterward.
BarcelonaAges 18 years+ - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07727551Recruiting
Nerve block before knee replacement for better recovery
This trial tests if a nerve block given a few weeks before knee replacement surgery can improve pain and function after the operation. It is designed for people who have certain risk factors that might make recovery harder.
BrusselsAges 18–60 - NCT07694895Recruiting
AI-assisted education for knee replacement recovery
This trial tests if an AI-powered educational video before you get up and walk after knee replacement surgery can help reduce fear of movement and make you feel more ready to leave the hospital.
Kocaeli, İzmitAges 18–100 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07672301RecruitingPhase 1/Phase 2
Comparing two anesthesia methods for knee replacement surgery
This trial compares total intravenous anesthesia (TIVA) with spinal anesthesia for people having a first-time total knee replacement who are expected to go home the same day. The goal is to see which method works better for recovery and comfort.
Chicago, IllinoisAges 18 years+ - NCT07630896RecruitingPhase 4
Prednisone and blood sugar monitoring after knee or hip replacement
This study looks at how a common steroid medicine, prednisone, affects blood sugar after knee or hip replacement surgery. It aims to find the best way to manage blood sugar for a smoother recovery.
New York, New YorkAges 18 years+ - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT07634523RecruitingPhase 4
Amino acids to prevent muscle loss after knee surgery
This study tests whether a supplement containing branched chain amino acids (special protein building blocks) can help prevent muscle loss in older adults having knee replacement surgery. The goal is to help patients recover strength and mobility more quickly after their operation.
Seongnam-si, Gyeonggi-doAges 40–100 - NCT07629388Recruiting
Nerve block for pain after knee replacement surgery
This trial tests whether adding a nerve block (a numbing injection near the nerve) to the usual pain plan can better control pain after a total knee replacement. The goal is to help you recover with less pain and fewer side effects.
DijonAges 18 years+
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Total Knee Arthroplasty trials by city
Studies with a site in or near these metro areas.
Total Knee Arthroplasty trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 225 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.