Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 228 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07552415Recruiting
Joint Immobilization After Knee Replacement Revision Surgery
This study tests whether keeping your knee still for a period after revision knee replacement surgery helps improve how well you can bend and straighten it. Researchers want to see if immobilization (using a brace or cast) helps you regain better movement compared to standard care.
New York, New YorkAges 18 years+ - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07589127Recruiting
Nerve Block for Pain Relief During Knee Replacement
This study tests whether blocking a specific nerve in the knee can reduce pain and improve recovery after total knee replacement surgery. You would receive this nerve block alongside standard anesthesia to see if it helps you need fewer pain medications afterward.
Hjelset, Møre og RomsdalAges 18–80 - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07286513Enrolling by invitation
Study of a new knee replacement implant
This study follows patients who receive a specific type of knee replacement implant called the Persona® SoluTion® PPS, to see how well it works over time. If your surgeon recommends this implant and you meet standard health requirements, you may be able to join.
Denver, ColoradoAges 18 years+ - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT07522489Recruiting
New knee replacement surgery guidance methods compared
This study compares two ways doctors use computer guidance during robotic knee replacement surgery for severe knee arthritis. The trial tests whether both methods work equally well or if one is better for patient recovery and results.
Warsaw, MazovianAges 18 years+ - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT05290818Recruiting
Robotic vs standard knee replacement for inner-joint wear
This trial compares robotic-assisted knee replacement with the usual (non-robotic) approach for people with severe arthritis on the inner (medial) side of the knee. It aims to see which method works better for pain and function while matching the right knee anatomy for certain implant types.
Edinburgh, LothianAges 50–75 - NCT04801654Recruiting
Knee replacement study using a specific metal implant coating
This study looks at outcomes after a primary knee replacement using the GMK Sphere TiNb implant. It may help researchers learn how well this specific implant works and how patients do over time.
Milan, MIAges 18 years+ - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT06880497Recruiting
Comparing knee sounds after two types of knee replacement
This study compares how much noise the knee makes (and how it feels to the patient) after two different kinds of total knee replacement surgery. It aims to help patients know what to expect after surgery.
AuxerreAges 18 years+ - NCT06758297Recruiting
AI motivational talk after knee replacement
This study tests whether an artificial intelligence-guided motivational conversation can help reduce fear of moving after knee replacement surgery, and improve how much you can move.
Samsun, SamsunAges 18 years+ - NCT06580899Enrolling by invitationPhase 4
Knee pain pump study for single knee replacement surgery
This study tests whether a small pain pump placed in your knee joint during surgery can help control pain after a single knee replacement. It is for people who are having outpatient knee replacement surgery and have not been taking strong pain medicines recently.
Charlotte, North CarolinaAges 18 years+ - NCT06203756Enrolling by invitation
Robotic-Assisted Knee Replacement Outcomes Study
This study tests a robotic-assisted system for knee replacement surgery. It aims to see how well patients do with the robotic help.
Flagstaff, ArizonaAges Any age - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05314491Recruiting
Follow-up study after knee replacement with a specific implant
This study follows people after they get a total knee replacement using the Multigen Plus system, sometimes with special cone pieces. It looks at how well the implant performs over time and whether results meet expectations.
GuimarãesAges 18 years+ - NCT05516381Recruiting
Navigation-assisted knee replacement with two alignment methods
This study tests a computer-guided technique for total knee replacement and compares two ways of aligning the new joint. It may help improve how accurately the surgery is done, which could affect comfort and function afterward.
BarcelonaAges 18 years+ - NCT07107581Enrolling by invitation
Exactech knee replacement follow-up study
This study is following patients who have or will receive an Exactech total knee replacement. It looks at how well the knee works over time and helps doctors understand long-term results.
DeLand, FloridaAges 18 years+
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Total Knee Arthroplasty trials by city
Studies with a site in or near these metro areas.
Total Knee Arthroplasty trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 228 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.