Clinical trials
Bowel Disease clinical trials
Below are recruiting bowel disease clinical trials, each written for real people, not researchers. We’re tracking 283 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05224089RecruitingPhase 4
Numbing shot comparison for pain control in laparoscopic colon surgery
This study compares two types of numbing injections (a longer-acting option versus standard numbing) placed near nerves to help control pain during laparoscopic colon surgery. It looks to see which method works better and is safe for patients having planned surgery.
Hartford, ConnecticutAges 18 years+ - NCT05456893Recruiting
Testing blood and stool markers in active ulcerative colitis treatments
This study checks biomarkers (signals in blood and/or stool) in adults with moderate-to-severe ulcerative colitis. It compares patients starting targeted medicines and looks for marker patterns that may reflect how the disease is behaving.
Nancy, LorraineAges 18 years+ - NCT05574387RecruitingPhase 2
Metformin added to treatment for ulcerative colitis
This Phase 2 study tests whether adding metformin to usual care can help people with mild to moderate ulcerative colitis. The goal is to see if it improves symptoms and disease control compared with standard therapy alone.
Al MansurahAges 18–75 - NCT05575505RecruitingPhase 2
Pentoxifylline added to ulcerative colitis treatment
This trial tests whether adding the medicine pentoxifylline to standard care can help people with ulcerative colitis. It’s designed to see if this combination improves symptoms by changing inflammation.
Al MansurahAges 18–75 - NCT05628701Recruiting
Testing two UC surgery reconstructions after colectomy
This trial compares two ways of reconnecting the bowel after subtotal colectomy and ileostomy in people with ulcerative colitis (UC). It may help determine which surgical option works best when the rectum is calm enough to manage with topical mesalazine alone.
GothenburgAges 18–60 - NCT05912387RecruitingEarly Phase 1
Testing statin treatment in primary sclerosing cholangitis
This early study looks at how a statin (cholesterol-lowering medicine) affects people with primary sclerosing cholangitis (PSC) by measuring changes using multiple types of health data. It may help researchers understand which people benefit and how PSC biology changes with treatment.
Stanford, CaliforniaAges 18–80 - NCT06165029Recruiting
Ultrasound score to predict anti-TNF success in IBD
This study tests whether an ultrasound score (called VAT) combined with another ultrasound score (IUS) can predict how well anti-TNF medications (like infliximab) work for people with inflammatory bowel disease. If you are starting a new anti-TNF treatment, this study may help doctors understand if the medication will be effective for you.
Changsha, HunanAges 18–80 - NCT06186752Recruiting
Action planning test for teens with IBD
This study tests if a planning tool helps teenagers with Crohn's disease or ulcerative colitis manage their condition. It's for patients aged 13 to 19 who have had their diagnosis for at least 3 months and are seen at UNC.
Chapel Hill, North CarolinaAges 13–19 - NCT06286709RecruitingPhase 2
Fecal transplant for PSC and colitis
This trial tests whether a fecal (stool) transplant from a healthy donor can help people with both PSC and inflammatory bowel disease. It aims to see if the treatment can improve liver health and reduce inflammation. You must have early to moderate liver scarring and be on stable medications.
BirminghamAges 18 years+ - NCT06287671Recruiting
Colorectal Surgery Tissue Study for Better Understanding of Disease
This study is collecting tissue samples from people having surgery on their colon or rectum to better understand colorectal diseases. It may help researchers learn more about conditions like cancer, polyps, or inflammatory bowel disease.
HillerødAges 18 years+ - NCT06309472RecruitingPhase 2
Mirtazapine for depression in inflammatory bowel disease
This trial tests whether the antidepressant mirtazapine can help people with Crohn's disease or ulcerative colitis who also have moderate or severe depression. If you are at least 18 and your IBD treatment is stable, this study could see if this medication improves your mood without interfering with your gut condition.
LondonAges 18–125 - NCT06382519Recruiting
Thalidomide for Very Early-Onset IBD in Kids
This study tests whether the drug thalidomide can help children with very early-onset inflammatory bowel disease (VEOIBD) when their symptoms are moderate to severe. It aims to see if thalidomide can calm the inflammation and improve quality of life.
Shanghai, Shanghai MunicipalityAges 4 weeks–6 years - NCT06453317RecruitingPhase 2
Comparing UC treatments: infliximab vs ustekinumab vs both
This study compares an existing UC medication (infliximab) with a newer one (ustekinumab) and a combination of both. The goal is to see which works best for moderate to severe UC when other treatments have failed.
LodzAges 18–64 - NCT06483373RecruitingEarly Phase 1
SPH7854 granules in healthy volunteers
This early-phase trial tests a new drug called SPH7854 granules in healthy people to check how the body processes it and if it's safe. You would take the drug and have regular check-ups.
ChengduAges 18–45 - NCT06512792Recruiting
Study on mobile app for managing inflammatory bowel disease
This study tests if a mobile app can help manage your inflammatory bowel disease (IBD) from home. You may be eligible if you have IBD that has been active in the last two years and you are between 18 and 75 years old.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06541938Recruiting
Breath test study for IBD in remission with IBS symptoms
This study tests a device called AIRE-2 that analyzes your breath to see if it can help manage IBD symptoms. It is for people with IBD who are in remission but still have IBS-like symptoms like belly pain or bloating.
Hamilton, OntarioAges 18–75 - NCT06571669Recruiting
Nerve stimulation device for ulcerative colitis
This trial tests a new medical device called BOOM-IBD2 that uses gentle nerve stimulation to treat ulcerative colitis. It's for people who have not had UC surgery and do not have certain infections or other implanted devices.
Folsom, CaliforniaAges 18–85 - NCT06580418Recruiting
Study of an anti-TREM-1 drug in a gut model
This trial tests a new drug that blocks a protein called TREM-1, which may help reduce inflammation in the gut. It uses tissue samples from people with active ulcerative colitis or Crohn's disease to see if the drug is effective.
MilanAges 18–60 - NCT06584162RecruitingPhase 4
Can vedolizumab be given less often for Crohn's or colitis?
This research study tests whether taking vedolizumab injections less often (every 4 weeks instead of every 2 weeks) can still keep your Crohn's or colitis in remission. If you are already well-controlled on standard vedolizumab, this study may help you and others by reducing the number of injections needed.
AmsterdamAges 18 years+ - NCT06599658RecruitingPhase 2
COVID-19 booster and flu vaccine timing for people with weak immune systems
This study tests the best timing for a COVID-19 booster and flu shot in people with weakened immune systems, such as organ transplant recipients, people living with HIV, or those with certain autoimmune conditions. It aims to help patients get better protection from both vaccines.
Montreal, QuebecAges 18 years+ - NCT06604273RecruitingPhase 2/Phase 3
Studying bowel scarring in ulcerative colitis with filgotinib
This trial tests if filgotinib can help reduce intestinal scarring in people with active ulcerative colitis. It aims to understand fibrosis and find better ways to monitor treatment.
Amsterdam, North HollandAges 18 years+ - NCT06696222Recruiting
Fermented vegan diet for health and colitis
This trial tests whether a fermented vegan diet can improve health in people with inflammatory bowel disease (IBD), like ulcerative colitis or Crohn's disease, and in healthy volunteers. It aims to see how the diet affects the gut.
MalmöAges 18 years+ - NCT06910553Recruiting
IBD Pregnancy Registry for mothers
This study is a registry that collects information from pregnant people with inflammatory bowel disease. By joining, you help researchers understand how IBD and treatments affect pregnancy and baby health.
Wilmington, North CarolinaAges 18–50 - NCT06917963Recruiting
Preventing high stoma output with omeprazole
This trial tests if a stronger dose of omeprazole can help prevent high fluid output from a new ileostomy (a surgically created opening in the belly that passes waste). If you are scheduled for surgery to create an ileostomy, you may be able to join.
Gdansk, Pomeranian VoivodeshipAges 18 years+
Hear when a new Bowel Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for bowel disease?
- Yes. Clin2 currently lists 283 recruiting bowel disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bowel disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bowel disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.