Clinical trials
Cancer (With or Without Metastasis) clinical trials
Below are recruiting cancer (with or without metastasis) clinical trials, each written for real people, not researchers. We’re tracking 13,299 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04138719RecruitingPhase 2
Test two chemotherapy combos before breast surgery for triple-negative cancer
This trial compares two different chemotherapy combinations given before surgery (neoadjuvant therapy) for people with triple-negative breast cancer. It looks to see which drug combination works better to control the cancer before and around the time of the operation.
Shijiazhuang, HebeiAges 18–70 - NCT04146298RecruitingPhase 1/Phase 2
KRAS-mutant pancreatic cancer T-cell therapy for some people
This Phase 1/2 study tests a lab-made immune cell (T-cell) treatment that targets a specific KRAS mutation (G12V) found in some pancreatic cancers. It may help shrink tumors or control cancer growth after standard treatment, and it mainly focuses on safety and early effectiveness.
ShanghaiAges 18–75 - NCT04159818RecruitingPhase 2
Adding immune treatments to improve checkpoint drug response in TNBC
This Phase 2 trial tests strategies meant to “prime” the immune system so that immune checkpoint medicines may work better in people with triple-negative breast cancer that has spread (or can’t be fully cured). You might be considered if your cancer has measurable areas that can be biopsied and you meet specific health and prior-treatment rules.
AmsterdamAges 18 years+ - NCT04185779Recruiting
Colorectal cancer screening colonoscopy study
This study looks at patterns of colorectal (colon and rectum) findings in people who are having a colonoscopy as part of routine care. It may help improve how doctors detect and understand colorectal cancer and related growths over time.
South Shields, Tyne and WearAges 18 years+ - NCT04199741RecruitingPhase 1/Phase 2
PET/CT scan test for small cell lung cancer marker DLL3
This trial tests a special PET/CT imaging scan that may help doctors find where small cell lung cancer (and some related tumors) are in the body using a DLL3 target. It’s a Phase 1/2 study, mainly to see how well the scan detects tumors and guides care.
New York, New YorkAges 18 years+ - NCT04235114RecruitingPhase 1/Phase 2
PET scan test for EGFR-positive cancers using an antibody tracer
This study tests a special PET scan agent (an antibody tracer) to help doctors see EGFR-positive cancers without needing invasive procedures. It is mainly for early testing (Phase 1/2) to understand how well it works for imaging.
Saskatoon, SaskatchewanAges 18–80 - NCT04278287RecruitingPhase 1/Phase 2
Chemoradiation study for unresectable esophageal cancer
This Phase 1/2 trial tests a treatment plan using chemotherapy plus radiation for esophageal squamous cell cancer that cannot be removed with surgery. It may help shrink or control the cancer and guide safer dosing, but it’s only for people with specific tumor stage, health status, and blood test results.
Anyang, HenanAges 18–75 - NCT04282356RecruitingPhase 2
Test of strong chemotherapy delivered inside the abdomen
This Phase 2 trial tests an intensive treatment for advanced ovarian, fallopian tube, or primary peritoneal cancer. It combines planned surgery to remove visible tumor with chemotherapy that is put directly inside the abdomen during the operation, aiming to control the cancer more effectively.
MontpellierAges 18–75 - NCT04288999RecruitingPhase 3
Surgery plus chemo versus chemo-radiation then surgery for recurrent rectal cancer
This study compares two treatment plans for locally recurrent rectal cancer: (1) surgery plus chemo, or (2) chemo plus radiation first, then surgery, followed by chemo. It aims to see which approach works better in controlling the cancer and helping patients recover.
ChibaAges 20–80 - NCT04291378Recruiting
Proton versus standard radiation for early breast cancer
This trial compares two types of radiation—proton therapy and standard photon therapy—for early breast cancer after surgery. It’s mainly for people whose usual radiation plan would put a higher dose to the heart and/or lungs, aiming to reduce that exposure.
AalborgAges 18 years+ - NCT04305834RecruitingPhase 2
Abemaciclib plus hormone pills for metastatic breast cancer in older adults
This Phase 2 study tests whether abemaciclib combined with standard hormone (endocrine) therapy can better control metastatic breast cancer in people age 70 and older. It may help if your cancer has already grown despite prior hormone therapy and/or other cancer medicines.
Duarte, CaliforniaAges 70 years+ - NCT04315233RecruitingPhase 1
Testing two drugs for hard-to-treat triple-negative breast and ovarian cancer
This Phase 1 trial tests ribociclib plus belinostat in people with metastatic triple-negative breast cancer or recurrent ovarian cancer. It also looks at your tumor’s genetics (from a fresh biopsy) to see who might respond better.
Salt Lake City, UtahAges 18 years+ - NCT04333706RecruitingPhase 1/Phase 2
Sarilumab plus capecitabine for certain breast cancers
This trial studies whether adding sarilumab to capecitabine can shrink or control metastatic or high-risk breast cancer that lacks HER2 and is either triple-negative or hormone-resistant. It aims to find a safe dose first, then look at how well the treatment works compared with historical results.
Los Angeles, CaliforniaAges 18–99 - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT04339374Recruiting
Ultrasound and light imaging during rectal cancer surgery
This study tests a newer kind of imaging (ultrasound plus light-based measurements) to help doctors tell rectal cancer apart from other tissue during surgery. You may be able to take part if you’re having surgery for rectal cancer and the tumor is close enough to the anus.
St Louis, MissouriAges 19 years+ - NCT04342429Recruiting
Proton radiation study for small cell lung cancer
This study looks at a type of radiation treatment using proton beams (IMPT) for small cell lung cancer. It may help assess whether this approach can safely deliver the planned radiation doses to the chest.
Atlanta, GeorgiaAges 18 years+ - NCT04362046Recruiting
Fertility-friendly treatment for early uterine cancer or precancer
This trial studies whether removing an early, hormone-responsive uterine growth using a procedure through the cervix can keep fertility possible. It is for people under 40 with a specific low-risk uterine biopsy and MRI findings who have already tried hormone treatment.
Vancouver, British ColumbiaAges 19–39 - NCT04362826Recruiting
Trial tests a probiotic to change gut microbes in breast cancer
This study gives a probiotic to see whether it safely changes the gut’s bacteria and fungi (your “microbiome”) in people with breast cancer. The researchers want to learn if this shift in gut microbes might support breast cancer treatment or health during care.
Cleveland, OhioAges 18–65 - NCT04370496Recruiting
Testing minimally invasive endoscopic stapler surgery for early cervix cancer
This trial tests how safe a specific minimally invasive surgery tool (an endoscopic stapler) is for people with early-stage cervical cancer. If you qualify, you would get surgery to remove the cervix area using a minimally invasive approach and the study will track safety outcomes.
SeoulAges 20 years+ - NCT04389086RecruitingPhase 3
Chemotherapy before surgery for recurring rectal cancer
This trial tests an “induction chemotherapy” treatment before surgery for people whose rectal cancer has come back in the local area. The goal is to shrink/control the cancer early and improve outcomes after treatment.
GhentAges 18 years+ - NCT04403867Recruiting
Study of tiny cancer spread found in sentinel lymph nodes
This trial studies whether very small deposits of cancer (called micrometastasis or isolated tumor cells) are found in sentinel lymph nodes in early endometrial or cervical cancer. The goal is to better understand what these findings may mean for cancer spread and treatment planning.
MilanAges 18 years+ - NCT04406662Recruiting
Study for people living with incurable cancer
This study enrolls adults with advanced, incurable cancer to better understand care and outcomes in everyday settings. It may help by guiding improvements for people receiving treatment for symptom relief (palliative care).
EdinburghAges 18 years+ - NCT04406831Recruiting
Testing microRNA for pancreatic cancer diagnosis and treatment response
This study looks at tiny molecules in your body (microRNA) to help doctors better diagnose pancreatic cancer, predict how it may progress, and understand how it responds to treatment. It may help guide more personalized care in the future.
Norwalk, ConnecticutAges 18 years+ - NCT04409860Recruiting
Adjuvant chemo after chemoradiation for advanced cervical cancer
This trial looks at whether adding chemotherapy after standard chemoradiation helps people with locally advanced cervical cancer. You may be eligible if your MRI after treatment still shows leftover tumor areas and your health and blood tests are within required limits.
Chongqing, Chongqing MunicipalityAges 18–75
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Common questions
- Are there clinical trials for cancer (with or without metastasis)?
- Yes. Clin2 currently lists 13,299 recruiting cancer (with or without metastasis) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cancer (with or without metastasis) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cancer (with or without metastasis) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Liver Metastasis Colon Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Colorectal Cancer Liver Metastasis
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Leptomeningeal Metastasis of Breast Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.