Clinical trials
Chronic Constipation clinical trials
Below are recruiting chronic constipation clinical trials, each written for real people, not researchers. We’re tracking 17 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03819062Recruiting
Stomach–bowel nerve stimulation for long-term constipation
This trial studies a device that stimulates nerves near the lower back (sacrum) to improve bowel function in people with severe constipation that hasn’t responded to standard treatments. It may help if your constipation involves problems coordinating bowel movement and the muscles around the rectum.
Hamilton, OntarioAges 6–70 - NCT06543979RecruitingPhase 1/Phase 2
Anorectal manometry for children with chronic constipation
This study is for children aged 4–16 who have long-term constipation that doesn't get better with standard laxatives. It uses a test called anorectal manometry to measure how well the muscles in the bottom work, which can help guide treatment.
CairoAges 4–16 - NCT06526767Recruiting
Vibrating capsule for chronic constipation dose comparison
This study tests three different doses of a vibrating capsule (Vibrabot) to see which works best for relieving chronic constipation. If you have had constipation for at least 6 months and meet the Rome IV criteria, you may be able to join.
Beijing, Beijing MunicipalityAges 18–85 - NCT07382167RecruitingPhase 3
Study of Tenapanor for Chronic Constipation in Adults
This study tests an investigational drug called tenapanor for people with chronic idiopathic constipation (constipation with no clear cause). It aims to see if the drug can safely improve bowel movements in adults.
Foley, AlabamaAges 18–80 - NCT06911749Recruiting
Using MSOT and MRI to measure bowel transit in children
This trial tests whether two imaging techniques, MSOT and MRI, can safely and non-invasively measure how long it takes for food to move through the bowels in children with chronic constipation or other bowel emptying problems. It may help doctors better understand and treat these conditions.
Erlangen, BavariaAges 1 year+ - NCT07705542Recruiting
Balloon use during biofeedback for constipation
This study tests whether using a balloon during biofeedback therapy helps people with constipation caused by pelvic floor dysfunction. It's for people who have trouble relaxing their pelvic floor muscles during bowel movements.
HullAges 18 years+ - NCT04838522Recruiting
Prucalopride for constipation in breastfeeding women
This study looks at whether prucalopride (Motegrity/Resotran) can help constipation symptoms in women who are breastfeeding. It also monitors the breastfeeding infant during the study while you follow sample-collection and interview requirements.
La Jolla, CaliforniaAges 18 years+ - NCT07032376Enrolling by invitation
Quick care pathway for chronic constipation
This study tests a faster care plan for people with chronic constipation. It will see if a simplified approach helps patients get the right treatment sooner.
Ann Arbor, MichiganAges 18 years+ - NCT06833684Recruiting
Comparing MOWOOT and trans-anal irrigation for constipation
This study tests two treatments for chronic constipation: a device called MOWOOT (which uses gentle abdominal massage) and trans-anal irrigation (a way to wash out the rectum). It is for people who have tried biofeedback therapy and still need help managing their constipation.
London, LondonAges 18 years+ - NCT06413368RecruitingPhase 2/Phase 3
Maralixibat for cystic fibrosis constipation
This trial tests a medicine called maralixibat to see if it helps children with cystic fibrosis who have chronic constipation that doesn't improve with standard treatments. The goal is to improve bowel movements and quality of life.
Los Angeles, CaliforniaAges 1–18 - NCT06106685RecruitingPhase 1/Phase 2
Washed microbiota transplant for chronic constipation
This trial tests a treatment called washed microbiota transplantation (a procedure that delivers healthy gut bacteria to your colon) for adults with chronic constipation. The goal is to see if it can improve bowel movements without the need for laxatives.
Nanjing, JiangsuAges 18–70 - NCT07387952Recruiting
Fecal transplant with nutrition help for chronic constipation
This trial tests if a fecal microbiota transplant combined with nutritional support can improve chronic constipation that hasn't gotten better with standard treatments. It's a small early study to see if the approach is safe and works.
BeijingAges 18–70 - NCT06847919Recruiting
Probiotic yogurt for chronic constipation
This study tests whether eating a special probiotic yogurt can help relieve chronic constipation. It may be a simple, natural addition to your diet with minimal side effects.
Suzhou, JiangsuAges 18–65 - NCT04506593Recruiting
GI Motility diagnosis registry for people with digestion movement problems
This trial is a registry, meaning it collects information about people being evaluated for problems with how the gut moves. It may help doctors better diagnose gastrointestinal motility disorders in the future.
Indianapolis, IndianaAges Any age - NCT06571097Recruiting
Levofloxacin for constipation from PIB bacteria
This study tests whether the antibiotic levofloxacin can help people with chronic constipation caused by a specific gut bacteria (PIB). If you have this bacteria and meet the other criteria, you may be able to join this trial to see if the treatment improves your symptoms.
Nanjing, JiangsuAges 18–70 - NCT07261826Recruiting
Long-term effects of fecal microbiota transplant
This study looks at how well fecal microbiota transplantation (FMT) works over time and checks its safety. If you have received at least one FMT for a qualifying condition, you may be able to participate.
Shanghai, Shanghai MunicipalityAges 3 years+ - NCT07202481Recruiting
Fiber supplements for constipation in women
This trial tests if two types of fiber—one from chicory and one from a plant husk—can help women with constipation move food through their intestines faster. It aims to find a gentle, non-drug option that might work better than what you eat now.
Belo Horizonte, Minas GeraisAges 18–59
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Common questions
- Are there clinical trials for chronic constipation?
- Yes. Clin2 currently lists 17 recruiting chronic constipation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic constipation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic constipation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.