Clinical trials
Chronic Non-Cancer Pain clinical trials
Below are recruiting chronic non-cancer pain clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06387706Recruiting
Web-based pain program for older adults
This study tests a fun, web-based program (GAP) to help older adults manage chronic pain through light exercise and coping skills. It's designed for Cantonese speakers who can use a smartphone.
Hong KongAges 60 years+ - NCT04587791RecruitingEarly Phase 1
Cannabidiol (CBD) for opioid use disorder and chronic pain
This early study tests whether CBD can reduce symptoms of chronic pain in people receiving opioid maintenance treatment for opioid use disorder. It also looks at safety and whether CBD can be added without causing major problems.
West Haven, ConnecticutAges 18–70 - NCT05963607Recruiting
Weighted blanket trial to reduce chronic pain
This study tests whether using a 15-pound weighted blanket can lower pain and improve sleep for Veterans with long-lasting, non-cancer musculoskeletal pain. It may help by reducing discomfort during rest and sleep.
San Diego, CaliforniaAges 18 years+ - NCT06058624Recruiting
Digital pain management program for veterans
This study tests a new digital program that helps veterans with long-term pain learn to accept and cope with it. You would use a computer at home to complete the program and share your feedback.
West Haven, ConnecticutAges 18 years+ - NCT06541184Recruiting
Ziconotide via spine pump for chronic non-cancer pain
This study looks at a medicine called ziconotide, given through a pump in your spine (intrathecal delivery) to treat chronic pain that is not from cancer. It aims to learn how safe and effective this treatment is in real-world patients.
AubagneAges 18 years+ - NCT06544291RecruitingPhase 2
THC and CBD for pain and opioid use disorder
This study tests whether a combination of THC and CBD can help people who have both opioid use disorder and chronic low back pain. You would need to be on a stable dose of methadone and have used cannabis at least once in your life.
New Haven, ConnecticutAges 18–65 - NCT06351046Recruiting
Preventing chronic pain from getting worse
This trial tests a virtual reality program to see if it can help prevent long-term pain from becoming more severe. You may be eligible if you have had pain for at least 3 months and rate your average pain as moderate or higher.
Copenhagen, København Ø.Ages 18 years+ - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT06856733Recruiting
Better opioid management for long-term non-cancer pain
This study tests a new way to help people who have been taking opioids for chronic pain (not caused by cancer) for at least 90 days. The goal is to improve treatment and reduce risks, such as developing tolerance or side effects, while still managing pain effectively.
Strängnäs, SörmlandAges 18–70 - NCT07038434Recruiting
Using artificial intelligence to measure pain in chronic pain patients
This study uses artificial intelligence to better understand and measure pain in people with chronic pain. The goal is to develop smarter ways to assess pain automatically, which could lead to better treatment.
Salerno, ItalyAges 18 years+ - NCT07057232Recruiting
Chronic insomnia treatment for non-cancer pain patients
This study is testing a treatment for chronic insomnia (trouble sleeping) in people who have long-term pain from non-cancer causes. Researchers want to see if improving sleep can help you manage your pain better.
Badalona, CataloniaAges 18 years+ - NCT07102446Recruiting
Opioid safety program for chronic pain patients without cancer
This trial tests a program to help manage opioid use safely for people with chronic non-cancer pain. If you take opioids for long-term pain and do not have cancer, this study may help improve your care.
Seoul, SeoulAges 19–79 - NCT07318519Recruiting
Virtual reality for chronic cancer pain
This study tests whether virtual reality (VR) can help reduce chronic pain in people with cancer. If you have had cancer pain for at least three months and rate your pain as 4 or more out of 10, you may be able to join.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06063902Enrolling by invitation
Long-term opioid therapy for chronic pain
This study looks at the risks and benefits of long-term use of opioids (strong painkillers) for chronic pain that is not caused by cancer. It aims to help doctors and patients make better decisions about pain management.
UppsalaAges 18 years+ - NCT06663956RecruitingPhase 3
Web app for cancer pain management study
This trial tests whether a special website or app can help people with cancer do a better job managing their pain. If you have moderate or severe cancer pain that needs morphine and you can use a simple app to track your symptoms, this may help you feel better.
Chengdu, SichuanAges Any age - NCT06100926Enrolling by invitation
Virtual reality for chronic muscle pain
This study tests whether virtual reality (VR) can help reduce chronic muscle pain that is not caused by cancer. If you have fibromyalgia or similar long-lasting muscle pain, you may be able to join.
Udine, Friuli Venezia GiuliaAges 18–50 - NCT07154056Recruiting
Spinal cord stimulation for stubborn nerve pain
This trial tests a new type of spinal cord stimulation for people with long-term nerve pain that hasn't improved with other treatments. The goal is to see if this special stimulation pattern can reduce pain better than standard care.
Poitiers, FranceAges 18–80 - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT07118332RecruitingEarly Phase 1
Psilocybin for chronic pain in veterans who smoke
This trial tests if psilocybin can help veterans with chronic pain who also smoke cigarettes. You will take psilocybin in a controlled setting to see if it reduces pain and helps with smoking.
West Haven, ConnecticutAges 21–65 - NCT07116109Recruiting
Brain Stimulation Plus Therapy for Pain and PTSD
This study tests whether a brain-stimulation headband (called tDCS) combined with a proven talk therapy for PTSD can help reduce both chronic pain and PTSD symptoms. It is for adults who have had chronic pain for at least 6 months and also have PTSD.
Charleston, South CarolinaAges 21 years+ - NCT07677631Recruiting
Emotional allodynia in fibromyalgia: a questionnaire study
This study compares how people with fibromyalgia and those with other long-term pain conditions experience emotional pain (like feeling hurt by emotions). You will fill out a questionnaire about emotional sensitivity. The goal is to see if emotional allodynia (pain from emotions) is more common in fibromyalgia.
BariAges 18 years+ - NCT07228377Recruiting
Virtual reality for cancer pain and opioid use
This study tests if using virtual reality can help manage chronic cancer pain and reduce the amount of opioid pain medicine needed. You would use a VR headset at home and report how you feel.
Washington D.C., District of ColumbiaAges 18 years+
Hear when a new Chronic Non-Cancer Pain trial opens
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Common questions
- Are there clinical trials for chronic non-cancer pain?
- Yes. Clin2 currently lists 22 recruiting chronic non-cancer pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic non-cancer pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic non-cancer pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Muscle Invasive Bladder Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.