Clinical trials
Cognition clinical trials
Below are recruiting cognition clinical trials, each written for real people, not researchers. We’re tracking 2,028 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05445180Recruiting
Brain scan study of thinking in cannabis users with psychosis
This study uses brain imaging to understand how thinking works in people who use cannabis, comparing those with psychosis to people without psychosis. It may help researchers learn what brain patterns relate to thinking difficulties and how cannabis use fits in.
Montreal, QuebecAges 16–80 - NCT05456321Recruiting
Brain stimulation and thinking training for prenatal alcohol effects
This study tests whether brain stimulation plus structured thinking practice can improve thinking and brain function in people affected by heavy alcohol exposure before birth. It may help parents and researchers learn how to support learning and daily functioning in fetal alcohol spectrum disorders.
Minneapolis, MinnesotaAges 8–17 - NCT05456607Recruiting
Digital therapy for insomnia and depression in veterans
This study tests an online form of cognitive behavioral therapy (a structured talk-therapy style program you use digitally) to help people who have both trouble sleeping and depression. It may be helpful if you’re a U.S. military veteran and your symptoms are in the study’s range.
Rochester, New YorkAges 18 years+ - NCT05460143Recruiting
Optical brain scanning to study memory and thinking
This study uses brain “optical” and possibly MRI scans to understand how thinking and memory work in people with Lewy body dementia, Alzheimer’s disease, or mild memory problems. It may help researchers find better ways to measure brain changes and cognition over time.
CambridgeAges 18 years+ - NCT05468905Recruiting
Study of aging and early thinking changes over time
This study follows adults 40+ to better understand and track changes in memory and thinking as people age. It groups people with normal thinking, subjective complaints, mild cognitive impairment, early Alzheimer’s, and vascular (blood vessel) related brain changes to find what predicts progression.
Hangzhou, ZhejiangAges 40–99 - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05527080Recruiting
Study brain and movement development in healthy infants
This study looks at how infants’ movement (motility) and early thinking (cognition) develop over time. It may help researchers better understand normal development in healthy babies.
HelsinkiAges 5 months–2.2 years - NCT05491538Recruiting
Work skills training for Veterans living with serious mental illness
This study tests whether a social-skills training program designed for work goals is doable and helpful for Veterans with serious mental illness. It focuses on improving work-related coping and interactions while you receive supported services through the VA.
Minneapolis, MinnesotaAges 18 years+ - NCT05495087Recruiting
Breathing low-oxygen air to test brain benefits in mild memory loss
This study tests whether breathing controlled low-oxygen air (through a disposable face mask) can improve brain function in people with mild cognitive impairment (MCI). You’d be randomly assigned to the real treatment or a sham (placebo-like) control, and you’d need multiple lab visits.
Fort Worth, TexasAges 55–79 - NCT05500170Recruiting
Study of nicotinamide riboside for sleep and thinking
This trial tests whether nicotinamide riboside can improve sleep quality and help with thinking and memory. You may be invited if your sleep is poor and you do not show signs of dementia on a brief mental test.
Buffalo, New YorkAges 65–85 - NCT05534607Recruiting
Community hula program for dementia risk in older Native Hawaiians
This study tests whether joining a community hula (dance) program can help people reduce future dementia risk. It focuses on older Native Hawaiian or Pacific Islander adults who already have mild memory concerns and certain health conditions like high blood pressure or diabetes.
Honolulu, HawaiiAges 50–75 - NCT05555693Recruiting
Brain chemistry study after surgery in older adults
This study looks at how brain “metabolomics” (small chemical signals in the brain/body) relate to thinking or mood problems that can happen after surgery in people age 65 and older. It may help doctors understand who is more likely to have these side effects after an operation.
Shanghai, Shanghai MunicipalityAges 65 years+ - NCT05565833RecruitingPhase 2
Online sleep program for insomnia and thinking problems
This Phase 2 study tests an internet-based sleep program to help older adults with insomnia and related thinking difficulties. It may help improve sleep and reduce how much tiredness and sleep disruption affect daily life.
Charlottesville, VirginiaAges 65 years+ - NCT05587127Recruiting
CBT therapy for eating anxiety in functional stomach pain
This trial tests an “exposure-based” type of cognitive behavioral therapy (CBT) to help people with functional dyspepsia (stomach discomfort after eating) who avoid or restrict food. The goal is to reduce food fear and improve eating and weight, after other medical causes have been ruled out.
Boston, MassachusettsAges 18 years+ - NCT05591027RecruitingPhase 1
Testing Centella asiatica for memory problems in older adults
This Phase 1 study tests whether Centella asiatica (a plant-based supplement) is safe and reaches its intended target in people with mild cognitive impairment or early Alzheimer’s disease. It also checks how it affects memory-related brain measures like MRI scans, which is why multiple scans are required.
Portland, OregonAges 60–85 - NCT05616559Recruiting
Precision-guided treatment for single-episode depression
This study tests a more personalized approach to treating depression in people who have had one episode. It uses questionnaires and brain scans (for some participants) to help decide which treatment approach may work best.
CopenhagenAges 18–65 - NCT05620719Recruiting
Study delayed headache after head injury in veterans
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
Los Angeles, CaliforniaAges 18–70 - NCT05653141Recruiting
Study for thinking problems after a first stroke
This trial looks at treatments or approaches to improve thinking and memory problems after a first stroke. You may be eligible if your stroke was in the front part of the brain, confirmed by MRI, and you enroll within 10 days.
BernAges 18 years+ - NCT05655325Recruiting
Exercise program to improve thinking in older adults with mild memory trouble
This study tests whether a supervised exercise plan can improve executive thinking (like planning and task control) in older adults with mild cognitive impairment. Researchers also look for brain changes using an MRI.
New York, New YorkAges 55 years+ - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05688618Recruiting
Probiotic and fiber supplement for mild memory problems
This trial studies whether a daily supplement containing a probiotic and a fiber called inulin can improve mild cognitive impairment (mild memory/thinking difficulties) in older adults. If you have mild cognitive impairment (not dementia), you may be asked to take the supplement and be monitored over time.
Mexico CityAges 70–85 - NCT05694039Recruiting
Track thinking changes in older adults with hearing loss
This study follows older adults who have age-related hearing loss to see whether wearing hearing aids helps protect thinking and memory over time. You may be included if your hearing loss is the type that hearing aids can usually improve and if your thinking test scores suggest mild cognitive difficulties.
Guangzhou, GuangdongAges 60–85 - NCT05695430Recruiting
Brief therapy for thoughts and stress with physical disabilities
This study tests a short kind of counseling called brief cognitive behavioral therapy to help people with physical disabilities and recent suicidal thoughts or attempts. It may help you manage distressing thoughts and feel safer and more in control.
Columbus, OhioAges 18 years+ - NCT05710991Recruiting
Brief therapy for sleep trouble in early pregnancy
This trial compares two short approaches to help with insomnia (sleep difficulties) during early pregnancy: brief cognitive behavioral therapy or sleep hygiene tips. It may help improve how well you sleep without using new or changing medications.
Hamilton, OntarioAges 18–45
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Common questions
- Are there clinical trials for cognition?
- Yes. Clin2 currently lists 2,028 recruiting cognition studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognition trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognition trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.