Clinical trials
Colon Cancer clinical trials
Below are recruiting colon cancer clinical trials, each written for real people, not researchers. We’re tracking 292 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05534087RecruitingPhase 3
Blood test guided chemo after colon cancer surgery
This study tests whether giving additional (adjuvant) chemotherapy based on a special blood test—circulating tumor DNA (ctDNA)—can lower the risk of colon cancer coming back. It targets people with stage II–III colon cancer whose blood test is positive for minimal residual disease (MRD) after completing standard chemo.
BusanAges 19–75 - NCT06801665RecruitingPhase 2
Fecal transplant plus immunotherapy and chemotherapy for colon cancer with liver spread
This trial tests a combination of fecal microbiota transplant (FMT), an immunotherapy drug (QL1706), a targeted therapy (bevacizumab), and chemotherapy (XELOX) as a first treatment for advanced colon cancer that has spread to the liver. The goal is to see if this mix can help shrink tumors and improve outcomes.
ChangzhouAges 18–75 - NCT05742425RecruitingPhase 2
Immunotherapy with chemo and targeted drug for colon cancer in the belly
This Phase 2 trial tests serplulimab (immunotherapy) combined with FOLFIRI chemo plus bevacizumab for colon cancer that has spread to the lining of the abdomen (peritoneal metastases). It aims to shrink these tumors and improve outcomes when surgery can’t fully remove them.
Huzhou, ZhejiangAges 18–75 - NCT06949111RecruitingPhase 2
Combining radiation and chemo to make colon cancer removable
This trial tests whether giving radiation therapy along with standard chemotherapy before surgery can help shrink advanced colon cancer that has grown through the bowel wall but hasn't spread to other organs. It is for a specific type of colon cancer called pMMR/MSS.
Shijiazhuang, HebeiAges 18 years+ - NCT05394714RecruitingPhase 1
Magicell-NK cell therapy after colon cancer surgery
This early-stage trial tests an individualized immune cell treatment (Magicell-NK) made from your own cells to help prevent colon cancer from coming back after surgery. It studies safety and how well the treatment works in people with early-stage colon cancer.
TaoyuanAges 20 years+ - NCT04089631RecruitingPhase 3
Blood test guides extra treatment after stage II colon cancer surgery
This study uses a blood test called ctDNA to decide whether you need extra (adjuvant) chemotherapy after stage II colon or certain stage II rectal cancer surgery. It may help avoid unnecessary treatment or better target people who still have signs of cancer after surgery.
Dresden, SaxonyAges 18 years+ - NCT06385418RecruitingPhase 2
Colon chemotherapy for colorectal cancer
This trial tests putting a chemo drug (fluorouracil) directly into the colon through a tube. It's for people with colorectal cancer who are already getting other cancer treatment, to see if adding local chemo helps shrink the main tumor.
Nanjing, JiangsuAges 18–75 - NCT06923787RecruitingPhase 2
Lidocaine for colon cancer surgery recovery
This trial tests whether giving lidocaine through an IV during and after colon cancer surgery can help with recovery and boost your immune system. It's for people having laparoscopic colon surgery who haven't had chemotherapy before.
LjubljanaAges 18–80 - NCT05283330RecruitingPhase 1
Tested 212Pb imaging drug for certain advanced GRPR tumors
This early-phase study tests how safe and tolerable an experimental radiation drug is for adults with certain advanced or metastatic cancers that show a target called GRPR. Doctors will also use special scans to confirm the tumor has the target so the treatment can be delivered to the right place.
Chicago, IllinoisAges 18 years+ - NCT06652672Recruiting
Sentinel Node and Organ-Sparing Surgery for Early Colon Cancer
This trial tests a less invasive surgery approach for early-stage colon cancer. It uses a special dye to find and remove only the first lymph node (sentinel node) while removing just the part of the colon with the tumor, possibly avoiding a bigger surgery.
AmersfoortAges 18 years+ - NCT06107920RecruitingPhase 3
Chemotherapy before surgery for blocked colon cancer
This trial tests whether giving chemotherapy before surgery helps people with colon cancer that caused a blockage and needed a temporary colostomy. It aims to improve outcomes compared to standard treatment.
AmiensAges 18 years+ - NCT06270017RecruitingPhase 1/Phase 2
Zebrafish Avatars for Colon Cancer Treatment
This trial uses tiny zebrafish to grow a piece of your tumor and test which treatments might work best for you. It is for patients with colon cancer who are scheduled for surgery to remove their tumor.
Linköping, Östergötland CountyAges 18 years+ - NCT06202183Recruiting
Home exercise for gut health in young colorectal cancer patients
This study tests whether a home-based exercise program can improve the health of your gut bacteria during chemotherapy for young-onset colorectal cancer. It aims to help you feel better and potentially improve how well your treatment works.
Boston, MassachusettsAges 18–50 - NCT03175224RecruitingPhase 2
Test drug APL-101 for lung or other tumors with MET changes
This Phase 2 study tests APL-101 to shrink advanced cancers that have certain MET-related changes, including specific MET mutations, MET gene amplification, or MET fusions. It may help people whose tumors have run out of standard treatment options.
Los Angeles, CaliforniaAges 18 years+ - NCT05424692Recruiting
Test tumor drug sensitivity to guide after-surgery colon cancer care
This study looks at whether testing a small tumor sample can identify which medicines are more likely to work for colorectal cancer after surgery. The results are used to help choose the best “after-surgery” treatment plan, when you have not had chemotherapy before surgery.
Beijing, Beijing MunicipalityAges 18–75 - NCT05652348Recruiting
Predicting outcomes after heated chemotherapy for stomach or colon spread
This study tries to better predict how well patients do after heated chemotherapy placed in the abdomen during surgery for stomach or colon cancer that has spread to the lining of the abdomen. It may help doctors choose the best treatment plan and timing for future patients.
DresdenAges 18 years+ - NCT05806931RecruitingPhase 2
Alternating two pills plus bevacizumab for advanced colon cancer
This Phase 2 study tests a treatment plan that alternates two cancer pills and adds bevacizumab (a blood-vessel drug) for metastatic colon cancer that has come back or worsened after standard treatment. It may help shrink tumors and slow disease growth after later-line therapy options.
Elizabeth, New JerseyAges 18 years+ - NCT06281145Recruiting
Stress reduction for breast or colon cancer patients
This study tests a stress-reducing program for people with breast or colon cancer. It uses a technique called heart rate variability biofeedback to help you manage stress during treatment.
BratislavaAges 18 years+ - NCT06462521Enrolling by invitation
Comparing two ways to remove large polyps during a colonoscopy
This study compares two methods for removing larger polyps (flat growths) found during a colonoscopy. It tests if one technique works as well or better than the other for people with certain types of polyps.
Indianapolis, IndianaAges 18 years+ - NCT07669519RecruitingPhase 3
Supplement for fatigue in stage IV colon cancer
This study tests an oral supplement (Nuvastatic) to see if it helps reduce fatigue in people with stage IV colon cancer who are starting chemotherapy for the first time. If you are 18–65 and have fatigue that is affecting you, this trial might offer a way to feel better.
Srikakulam, Andhra PradeshAges 18–65 - NCT07108517Recruiting
Post-traumatic growth program for cancer survivors in Greece
This trial tests a guided program to help people with breast, colorectal, or head and neck cancer find personal growth after finishing chemotherapy. It is for those who have completed their planned treatment within the last 5 years and are not currently in other psychological care.
ThessalonikiAges 18–80 - NCT04025541Recruiting
Blood tests to study tumor markers
This trial looks at blood samples to measure substances that may reflect cancer (tumor markers). It may help doctors understand cancer better and improve future monitoring, as long as you can safely and regularly take part.
MontpellierAges 18 years+ - NCT07529808RecruitingPhase 1/Phase 2
New Drug BHB810 for Advanced Stomach Cancer
This trial tests a new drug called BHB810 for gastric (stomach) and gastroesophageal junction cancer that has stopped responding to standard treatments or has no standard options available. The drug targets a protein called CDH17 found on cancer cells and may help slow or shrink the tumor.
Fairfax, VirginiaAges 18 years+ - NCT05434026Recruiting
Colorectal cancer database study for people having surgery
This study enrolls people with colon cancer found on biopsy and who are able to have surgery. It mainly builds a medical database to help researchers understand care and outcomes, and it depends on you consenting to participate.
BeijingAges Any age
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Common questions
- Are there clinical trials for colon cancer?
- Yes. Clin2 currently lists 292 recruiting colon cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colon cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colon cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Beyond the search
We also like to point to nonprofits doing real good in this area. We aren’t affiliated with them — we just admire the work.
- Stand Up To CancerPeople facing cancer across many types, through the research that leads to better treatments.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.