Clinical trials
Crohn’s disease clinical trials
A type of inflammatory bowel disease causing inflammation of the digestive tract. We’re tracking 333 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06663332RecruitingPhase 3
Long-term study of guselkumab in children who previously took it
This study is a long-term follow-up for children who have already finished an earlier study of guselkumab, a medicine for skin conditions like psoriasis. It looks at whether staying on the medicine continues to be safe and helpful over time.
Atlanta, GeorgiaAges 3 years+ - NCT06495658Recruiting
Prebiotics for ulcerative colitis symptoms
This trial tests whether a prebiotic supplement can improve symptoms of ulcerative colitis. It may be a good option for people with active symptoms who are already on stable medications.
Los Angeles, CaliforniaAges 18–85 - NCT06197334Recruiting
Recording stomach and gut signals with skin sensors
This study uses small sensors placed on your belly to record electrical signals from your stomach and intestines. It may help doctors better understand conditions like Crohn's disease and other digestive issues without using needles or inside-the-body tests.
Vandœuvre-lès-Nancy, CHRU de NancyAges 18 years+ - NCT05974280Recruiting
Stem cell treatment for complex anal fistulas
This trial compares two types of stem cell treatments to help heal complex anal fistulas (abnormal tunnels near the anus). You may be eligible if your Crohn’s-related disease is mostly controlled and the fistula has not fully healed with standard treatments.
Nantes, NantesAges 18 years+ - NCT05660746RecruitingPhase 2/Phase 3
Infliximab dose tailored to control Crohn’s inflammation
This trial tests a more precise way to start infliximab (a Crohn’s medicine) and adjust dosing based on how your body responds. It aims to better control Crohn’s inflammation early and keep it under control.
Los Angeles, CaliforniaAges 6–22 - NCT05421455Recruiting
Early vs delayed surgery for Crohn’s bowel narrowing
This study compares two timing choices for surgery in people with Crohn’s disease who have bowel narrowing (strictures) causing blockage symptoms. The goal is to see whether operating earlier leads to better control of symptoms and inflammation when other treatments haven’t worked.
Nanjing, JiangsuAges 18–60 - NCT05230173Recruiting
Treat to endoscopic remission in inflammatory bowel disease
This study tests whether switching to a different treatment for inflammatory bowel disease (IBD) can achieve healing of the gut lining. It is for people whose symptoms are under control but who still have significant inflammation in their bowel.
Scottsdale, ArizonaAges 18 years+ - NCT05169593RecruitingPhase 4
Prevent Crohn’s return after surgery: endoscopy-guided vs standard medicine
This study compares two ways to choose biologic (targeted) medicines after Crohn’s surgery to help stop Crohn’s from coming back in the bowel. It may help you avoid or delay repeat inflammation by adjusting treatment based on endoscopy findings.
Antwerp, AntwerpenAges 18–80 - NCT06802887Recruiting
Long-term study of ustekinumab for Crohn's and colitis
This study follows patients with Crohn's disease or ulcerative colitis who started taking ustekinumab between February 2019 and March 2021, to see how well it works over time.
Bologna, BolognaAges 18 years+ - NCT07539727Recruiting
Intestinal ultrasound to predict Crohn's disease flare-ups
This study tests whether a special ultrasound of the intestines can predict when Crohn's disease will flare up again in patients whose disease is currently well-controlled. If successful, doctors could catch flare-ups earlier and adjust treatment before symptoms worsen.
Guangzhou, GuangdongAges 18–70 - NCT07529236Recruiting
How Children's Bowel Disease Responds After Switching IBD Medications
This study follows children who had to stop one type of IBD medicine (anti-TNFα) because it caused a skin condition called psoriasis, and were switched to a different medicine called ustekinumab. Researchers want to see how well their bowel disease is controlled with the new treatment.
Nice, FranceAges 6–17 - NCT06064864Recruiting
Switching Infliximab from IV to Subcutaneous for Crohn's
This study tests whether switching from an IV infliximab to a subcutaneous (under-the-skin) version is safe and works well for people with moderate to severe Crohn's disease. It's for people who have never used a biologic and need a new treatment option.
SeoulAges 18–100 - NCT07691138RecruitingPhase 4
Stopping acid-reducing pills in stable IBD
This study tests whether it is safe to stop taking acid-reducing pills (PPIs) for people with inactive IBD. If you have been on a PPI for over 6 months and your IBD is stable, you may be able to join.
NottinghamAges 16 years+ - NCT07672574RecruitingPhase 1
Study of how ontunisertib is processed in healthy men
This study tests how a new drug, ontunisertib, is processed by the body and eliminated. Healthy men will take a single dose with a tiny radioactive tracer so researchers can track the drug.
NottinghamAges 30–65 - NCT07680283Recruiting
Ultrasound-guided surgery for Crohn's disease of the small intestine
This study compares two ways for surgeons to decide where to cut the intestine during surgery for Crohn's disease. One uses an ultrasound probe during the operation, and the other uses the standard method of feeling the tissue. The goal is to see if ultrasound guidance leads to better outcomes.
Cleveland, OhioAges 18 years+ - NCT07426003Recruiting
Healthy volunteer nutrition study with a special drink
This study looks at how healthy adults digest a special nutritional drink. Researchers want to understand normal digestion to help improve care for people with feeding tubes.
Philadelphia, PennsylvaniaAges 18–70 - NCT04846959Recruiting
Pregnancy outcomes study for people exposed to risankizumab
This study looks at pregnancy outcomes in people who took risankizumab during pregnancy (or shortly before getting pregnant). It compares them with pregnancies exposed to similar biologic medicines, to better understand risks and what to expect.
Morrisville, North CarolinaAges Any age - NCT06533228Recruiting
Testing a shorter MRE for Crohn's disease
This trial is testing a shorter, quicker MRE (magnetic resonance imaging of the small bowel) for people with Crohn's disease. It aims to see if the abbreviated scan still provides good images for monitoring inflammation, narrowing, or fistulas.
Rochester, MinnesotaAges 10 years+ - NCT03256240Recruiting
Two surgical options for Crohn’s bowel resection
This trial compares two ways of reconnecting the bowel after surgery in people with Crohn’s disease that affects the small intestine and/or colon. It aims to see which reconnection method works better after the initial surgery, even if you’re on Crohn’s medicines before the operation.
Boston, MassachusettsAges 18–90 - NCT07168499Recruiting
Diet, stress, and advanced therapy for Crohn's and colitis
This study tests whether adding a diet and stress management program to standard advanced therapy helps people with active Crohn's disease or ulcerative colitis feel better. It combines lifestyle changes with new medications to improve treatment outcomes.
Boston, MassachusettsAges 18 years+ - NCT03894228Recruiting
Study of Crohn’s and colitis medicines during pregnancy and breastfeeding
This registry study tracks outcomes for mothers with inflammatory bowel disease (IBD) and their babies during pregnancy and breastfeeding while using IBD medicines. It aims to better understand the safety of these medicines so future pregnancies can be managed more confidently.
Santiago de Compostela, A CoruñaAges 18 years+
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Common questions
- Are there clinical trials for crohn’s disease?
- Yes. Clin2 currently lists 333 recruiting crohn’s disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn’s disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn’s disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.