Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 192 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07152925Recruiting
Brain stimulation for impulse control in teens with self-injury
This trial tests whether a gentle electrical current applied to the scalp can improve impulse control in adolescents who harm themselves without wanting to die. The goal is to see if this non-invasive treatment can help reduce self-injury urges.
Hefei, AnhuiAges 12–22 - NCT07107906Recruiting
CONNECT program: group telehealth to reduce loneliness in adults 55+
This trial tests a group-based telehealth program called CONNECT, which aims to reduce loneliness, social isolation, and mental health symptoms like anxiety or depression in adults aged 55 and older. You'll join online group sessions instead of in-person programs, making it easier to connect from home.
Winnipeg, ManitobaAges 55 years+ - NCT07097545Recruiting
Social media, exercise, and mindfulness for college students
This study tests whether limiting social media to a few minutes daily and doing brief exercise or mindfulness activities for two weeks can improve well-being. It is for Johns Hopkins students who use social media a lot and currently exercise an hour or less each day.
Baltimore, MarylandAges 18 years+ - NCT07051200Recruiting
Support program for young adults after a mental health crisis
This study offers a program to support young adults who recently faced a mental health crisis. It aims to help you recover by providing inspiration, support, and empowerment after a hospital stay.
Dallas, TexasAges 18–27 - NCT06901739Recruiting
Synbiotic for mental health in obesity
This trial tests if a synbiotic (a mix of probiotics and prebiotics) can improve mental health in people with obesity. It may help if you have obesity and also struggle with anxiety or depression.
Valencia, ValenciaAges 18–65 - NCT06755710Recruiting
Patient engagement study for PTSD treatment
This trial tests whether a program that helps people actively take part in their PTSD treatment leads to better outcomes. It is designed for adults with PTSD, including refugees, and aims to improve treatment engagement and results.
Ballerup Municipality, Capital RegionAges 18 years+ - NCT06635486Recruiting
Mental health support for Venezuelans in Lima
This study offers mental health support to Venezuelan adults living in Lima who are feeling anxious, depressed, or have experienced trauma. It will check if you have signs of depression, anxiety, or post-traumatic stress and provide help if you do.
LimaAges 18 years+ - NCT06290778Enrolling by invitation
Mental health prevention training for fire fighter trainees
This study tests a program where peers teach emotion regulation skills to help prevent mental health issues in new fire fighters. You would be asked to complete surveys and attend training sessions.
Waco, TexasAges 21 years+ - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT02604277Recruiting
Study of suicidal behavior in people with bipolar disorder
This study looks at suicidal thoughts or behaviors in people diagnosed with bipolar disorder. It may help researchers understand what leads to suicidal risk and how to better support safety and treatment.
Atlanta, GeorgiaAges 18–64 - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT06706323Recruiting
Depression after heart surgery study
This study looks at depressive symptoms in people who have had heart bypass surgery. It aims to understand how patients feel emotionally after surgery and may help improve care.
ZurichAges 18–90 - NCT07413874Recruiting
Music therapy over video for depression and hormone disorder
This trial tests if telehealth music therapy can help adults who have both an endocrine autoimmune disease and depression. You'll join sessions from home using Zoom.
Boone, North CarolinaAges 18–65 - NCT07653022Enrolling by invitation
Turkish symptom questionnaire for Turkish speakers with language barriers
This study tests a Turkish version of a questionnaire for Turkish-speaking patients who have psychological complaints but face language barriers. It aims to help doctors better understand their symptoms.
Jette, Brussels CapitalAges 18 years+ - NCT07613008Recruiting
Mobile app to prevent perinatal depression and anxiety
This study tests a personalized smartphone app designed to help pregnant women and their partners prevent depression and anxiety during pregnancy and after birth. Participants use the app for support and receive check-ins from healthcare providers.
Mairena del Aljarafe, SevillaAges 18 years+ - NCT07556692Recruiting
Home Brain Stimulation for Bipolar Depression
This study tests whether a device you use at home can help reduce depression symptoms in people with bipolar disorder. The device uses gentle electrical stimulation on the scalp to potentially improve mood.
LondonAges 18 years+ - NCT07544563Recruiting
Brain Activity During Sound Testing
This study measures how your brain responds to sounds in a specially designed quiet room. Researchers want to understand how epilepsy affects sound processing, which could help improve treatment in the future.
ParisAges 18 years+ - NCT07503951Recruiting
Talking therapy for inpatients in psychiatric care
This trial tests whether cognitive behavioral therapy (CBT) works for people staying in a psychiatric hospital. You should be staying for at least three days and able to talk through your thoughts and feelings.
StockholmAges Any age - NCT07409298Enrolling by invitation
AI support for breast cancer patients on CDK4/6 inhibitors
This trial tests whether an AI-powered management program can improve mental health and daily habits for people with HR+/HER2- breast cancer who are taking CDK4/6 inhibitor pills at home. It is designed to help you feel supported and stay on track with your rehabilitation plan.
TianjinAges 18–80 - NCT06917950RecruitingPhase 1/Phase 2
Roxadustat for bone and brain health in dialysis patients
This study tests whether roxadustat, a medicine for anemia, can also help with bone problems and mood or thinking issues in people on hemodialysis.
Al Mansurah, DakahliyaAges 18 years+ - NCT06975280Recruiting
PTSD therapy for unaccompanied refugee teens in Greece
This study tests a talking therapy (Trauma-Focused Cognitive Behavioral Therapy) to help unaccompanied refugee minors aged 15-18 who have PTSD or stress symptoms from trauma. It aims to see if the therapy reduces distress and helps them feel better.
AthensAges 15–18
Hear when a new Depression - Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 192 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.