Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 192 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05676918Recruiting
Postpartum well-being study for mothers in the past year
This study looks at mothers’ well-being after having a baby, to understand what affects mental and emotional health after childbirth. It may help improve support for mothers during the postnatal period.
Madrid, Pozuelo de AlarcónAges 18 years+ - NCT06770517Recruiting
Exposure therapy for anxiety in older adults
This study tests whether exposure therapy helps older adults with anxiety. It focuses on people 60 and older who have conditions like generalized anxiety, panic disorder, agoraphobia, or social anxiety.
Nederland, NijmegenAges 65 years+ - NCT07025590Recruiting
Exercise to help lower antidepressants for heart patients
This trial tests whether adding a structured exercise program can help people with both depression/anxiety and heart disease slowly reduce their antidepressant medication. It may offer a way to lower medication use while improving heart and mental health.
Guangzhou, GuangdongAges 18–70 - NCT06881758Enrolling by invitation
High intensity training for anxiety treatment
This study tests whether high intensity exercise can help reduce anxiety symptoms. It is for adults with mild to moderate anxiety disorders who are physically able to exercise.
TromsøAges 18–65 - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
Phoenix, ArizonaAges 18 years+ - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT06790641Recruiting
Supporting mental health during and after pregnancy
This study aims to improve mental health care for people during and after pregnancy. It involves interviews or focus groups with healthcare providers, peer mentors, and patients to understand how to make support services more helpful and accessible.
Shrewsbury, MassachusettsAges 18–70 - NCT07704138Recruiting
Testing process-based therapy for depression and anxiety
This trial tests a type of talking therapy called process-based therapy to see how well it works in everyday care. It focuses on treating depression or anxiety and helps therapists learn how to make better treatment decisions.
Frankfurt am Main, HesseAges 18–65 - NCT07561632Recruiting
Early Stress Screening After Emergency Cesarean Delivery
This study looks at whether certain signs of distress right after an unexpected cesarean delivery can predict who might develop PTSD (post-traumatic stress disorder) later. Researchers want to understand this connection so they can help women who are struggling after this traumatic birth experience.
Vancouver, British ColumbiaAges 19 years+ - NCT07436351Recruiting
ACT With CF Self-Help Toolkit
This trial tests an online self-help program based on acceptance and commitment therapy (ACT) for adults with cystic fibrosis who are feeling depressed or anxious. It aims to help you manage these feelings and improve your well-being.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07420322Recruiting
Testing brain stimulation for depression and related symptoms
This trial studies a non-invasive brain stimulation treatment for people with depression or related symptoms that haven't improved with standard treatments. The goal is to see how well it works in real-world settings.
MünchenAges 18 years+ - NCT07280481Recruiting
Mindfulness for emotional distress
This trial tests a weekly mindfulness program to help people with anxiety or depression. It aims to see if learning mindfulness can improve your emotional health.
BeijingAges 18 years+ - NCT06633458Recruiting
Family communication in teen psychiatric care
This trial looks at how teens in a hospital psychiatry unit feel about talking with their parents and whether that affects their treatment progress.
Hamburg, Free and Hanseatic City of HamburgAges 14–17 - NCT06298279Recruiting
Online CBT for public safety personnel in Canada
This study tests an online therapy program (cognitive behavioral therapy, or CBT) designed specifically for public safety personnel. It looks at how the timing of the course and learning from others affects your progress. You can join from anywhere in Canada.
Regina, SaskatchewanAges 18 years+ - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT05624931Recruiting
Helping pregnant women stay on PrEP after starting it
This study tries to reduce the psychological barriers that make it hard for pregnant or postpartum women to keep taking PrEP. It may help by offering support tailored to stress, trauma symptoms, or depression—especially soon after PrEP is started.
Boston, MassachusettsAges 15 years+ - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT05074901Recruiting
Using a health app in France with virtual support
This trial tests whether a digital health app (with “virtual agents,” like guided prompts/support) can improve people’s health outcomes. You may help the study by using the app and completing its questionnaires.
BordeauxAges 18 years+ - NCT06773338Recruiting
Can playing Tetris improve mental health for migrants?
This study tests if playing the game Tetris can help reduce stress and improve mood for Arabic-speaking immigrants who have applied for asylum. You would play Tetris a few times and report how you feel.
The Hague, NLAges 18 years+ - NCT03987633Recruiting
Study links health records and samples to understand health gaps
This study asks people affected by a specific illness (or their family member) to share saliva (and sometimes blood) and answer health and quality-of-life questions. The goal is to better understand and reduce health inequality by matching new information with medical records.
Wolverhampton, West MidlandsAges 6 years+ - NCT07239609RecruitingPhase 1
ACT therapy for memory loss and their caregivers
This study tests if ACT, a type of talk therapy, helps people with mild memory loss and their care partners cope with difficult emotions. Both you and a family member or friend who helps you would participate.
Lubbock, TexasAges 18 years+ - NCT07032480Recruiting
Sleep, Neck Pain, and Depression Study
This study looks at how sleep problems, neck pain, and depression might be connected in healthy young adults. It aims to help understand these common issues better.
Istanbul, ÜsküdarAges 18–28 - NCT06215313Enrolling by invitation
Comparing two therapies for trauma memories
This study compares two types of therapy—EMDR and imagery rescripting—to help people who have upsetting memories or nightmares from past events. It's for people with depression or PTSD, and you'll need to come to therapy twice a week.
Eindhoven, North BrabantAges 18–70 - NCT05323864Recruiting
Altitude exposure study for anxiety and low mood
This trial looks at what happens to people with anxiety and depressive symptoms after going to high altitude with low oxygen. It may help researchers understand whether altitude affects these symptoms and how it might be managed.
Innsbruck, TyrolAges 18–65
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Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 192 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.