Clinical trials
Major Depression Moderate clinical trials
Below are recruiting major depression moderate clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT07740694Recruiting
ECT study for older adults with depression
This study looks at how ECT affects brain activity and inflammation in older adults with depression. It may help researchers understand why ECT works and improve treatment.
Istanbul, BakırköyAges 55 years+ - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT07562191RecruitingPhase 2
Inhaled DMT for major depression
This trial tests if inhaling DMT can help treat moderate to severe major depression. You may qualify if your depression has lasted at least two weeks and you have not changed medications recently.
Fortaleza, CearáAges 18 years+ - NCT07510880Recruiting
Home brain stimulation for major depression
This trial tests a home-based brain stimulation device (tDCS) to treat depression. You would use a headset daily for a few weeks, and the study team will check in to make sure it's working safely and effectively.
L'Hospitalet de Llobregat, BarcelonaAges 18–65 - NCT07512284RecruitingPhase 2
Mindfulness and Brain Stimulation for Treatment-Resistant Depression
This study combines mindfulness practice with transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to help people with depression that hasn't improved with antidepressant medications. The goal is to see if adding mindfulness to TMS improves how well the treatment works.
San Diego, CaliforniaAges 18–65 - NCT07282678Recruiting
Adaptive brain stimulation for treatment-resistant depression.
This study tests a new brain stimulation device that adjusts its signal in real time to treat depression. It's for people who haven't gotten enough help from antidepressants and are looking for a non-drug option.
Durham, North CarolinaAges 22 years+ - NCT07263321Recruiting
Depression treatment choice in general practice
This study helps people with moderate depression decide between medication and therapy. Your doctor will work with you to pick the best option.
AalborgAges 18–65 - NCT07146269Enrolling by invitation
Virtual reality and brain stimulation for depression
This study tests if combining virtual reality with a gentle brain stimulation method at home can help people with major depression. You would use a headset and small electrodes to receive treatment in your own home.
MunichAges 18–65 - NCT07140575Recruiting
Brain stimulation for teens with depression in the hospital
This trial tests if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help teens with depression who haven't gotten enough relief from therapy or medication. It's designed for youth who are currently in the hospital or planning to be admitted.
Toronto, OntarioAges 14–19 - NCT07082998Recruiting
Heated yoga vs. sauna for depression
This study compares heated yoga with sauna sessions to see which helps reduce depression. You'll also use a mindfulness app. Both treatments are meant to boost mood and well-being.
Boston, MassachusettsAges 18–65 - NCT07041073Recruiting
Brain training for emotion control in depression
This trial tests if a non-invasive brain training technique called neurofeedback can help people with major depression improve how they manage emotions. You participate by doing computer tasks while your brain activity is measured and shown back to you, teaching you to regulate your emotions better.
Sabadell, Barcelona, CataluñaAges 18–65 - NCT06832605Recruiting
Mindfulness classes by video to prevent depression relapse
This trial tests an 8-week mindfulness-based cognitive therapy program delivered via video call to help people with a history of depression prevent future episodes. It may help you learn skills to manage low mood and reduce the chance of relapse.
Elche, AlicanteAges 18 years+ - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Birmingham, AlabamaAges 18–85 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT06523439Recruiting
Brain stimulation for depression in young people
This study tests a new type of brain stimulation called accelerated intermittent theta burst stimulation (aiTBS) in young people (ages 13-20) with depression who have not tried many treatments before. The goal is to see if this treatment can safely help reduce depression symptoms.
Austin, TexasAges 13–20 - NCT06396312Recruiting
Predicting lithium response in difficult depression
This study looks at how to predict which people with hard-to-treat depression will benefit from adding lithium to their antidepressant. If you have treatment-resistant depression and are considering lithium, this trial may help find the best treatment for you.
Munich, BavariaAges 18 years+ - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT07523048RecruitingPhase 2
Dextromethorphan-Bupropion for Moderate-to-Severe Depression
This study tests a combination medication (dextromethorphan plus bupropion) to see how it affects brain activity in people with moderate-to-severe depression. Researchers use brain imaging (fMRI) to understand how the drug works and whether it may help relieve depression symptoms.
Toronto, OntarioAges 18–65 - NCT04637620RecruitingPhase 2
NMDA-based treatment study for major depression
This Phase 2 trial tests whether an NMDA-targeted treatment can improve symptoms of major depressive disorder (MDD). You may be able to join if your depression diagnosis and symptom score fit, and you meet several safety and study-following requirements.
TaichungAges 18–55 - NCT05136755RecruitingPhase 2
NMDA treatment for depression that did not improve
This trial studies an NMDA-based treatment for people with major depressive disorder who did not respond to at least one antidepressant. It may help by changing brain signaling linked to depression symptoms.
TaichungAges 18–65 - NCT05441969Recruiting
Brain stimulation study for major depression symptoms
This trial studies a way to change how excitable the brain is (through in-person brain stimulation) in people with major depression. It may help understand new treatments or symptom patterns that could be useful for major depression.
LisbonAges 18–65 - NCT07226661RecruitingPhase 2
Study of an investigational drug for depression
This trial tests an investigational medication for adults with major depressive disorder who are currently taking an antidepressant but still have symptoms. It aims to see if adding this new drug can improve mood better than a placebo.
Garden Grove, CaliforniaAges 18–70
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Common questions
- Are there clinical trials for major depression moderate?
- Yes. Clin2 currently lists 165 recruiting major depression moderate studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression moderate trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression moderate trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.