Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 192 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT07552246RecruitingPhase 4
Acupuncture vs medication for depression and anxiety
This study compares acupuncture with standard medication for reducing depression, anxiety, and related sleep problems. It aims to see if acupuncture is a helpful alternative for people in China who are struggling with these conditions.
Kunshan, JiangsuAges 18–65 - NCT06892613Recruiting
Couples therapy for depression and anxiety in married couples
This trial compares two types of couples therapy (EFCT and BCT) to see which works better for depression and anxiety. If you and your spouse are feeling stressed, anxious, or low, this study may help you strengthen your relationship and improve your mood.
Istanbul, IstanbulAges 18–65 - NCT07022184Recruiting
Lifestyle app for depression with GP support
This trial tests a lifestyle app to help people with depression who are under a GP's care. It looks at whether using the app alongside your usual treatment can improve your mood.
Nijmegen, GelderlandAges 18 years+ - NCT05950698Recruiting
Study of obesity and bariatric surgery with mental and social factors
This study looks at how personal mental health and life circumstances relate to outcomes after bariatric (weight-loss) surgery. It may help the team understand what supports improve recovery and health after surgery.
Rio de Janeiro, Rio de Janeiro, BrazilAges 18–60 - NCT07651436Recruiting
Depression screening in patients on kidney dialysis
This study tests whether nurses can effectively screen for depression in patients receiving regular kidney dialysis treatment. The goal is to find the best way to identify depression early so patients can get help.
AnnecyAges 18 years+ - NCT07680153RecruitingPhase 4
Brain stimulation for bipolar depression
This study tests a non-invasive brain stimulation technique to see if it can improve mood in people with bipolar disorder who are currently experiencing depression. It aims to understand how the brain's mood circuits work.
New York, New YorkAges 18–70 - NCT06906003Recruiting
Vision rehab and depression in age-related macular degeneration
This trial tests whether visual rehabilitation can help improve both vision and mood in people with advanced dry age-related macular degeneration. It aims to understand the link between vision loss and depression.
Rome, ItalyAges 55 years+ - NCT06702761Recruiting
Depression among heart surgery healthcare workers in Baghdad
This study aims to find out how common and how severe depression is among healthcare workers in cardiothoracic surgery departments in Baghdad. It uses a questionnaire called PHQ-9 to screen for depression symptoms.
BaghdadAges 18 years+ - NCT01415310Recruiting
Registering geriatric mental health patients and families
This study sets up a quality registry to better understand and improve care in geriatric psychiatry units. It includes patients who receive care there and their relatives, as long as they agree to take part by signing consent.
OsloAges 65 years+ - NCT07865052Recruiting
Psychological support before complex stomach or intestinal surgery
This study tests whether a psychological program before major abdominal surgery can help reduce distress and improve recovery. Participants will receive extra mental health support to prepare for their operation.
Chicago, IllinoisAges 18 years+ - NCT07707453Recruiting
Studying work and well-being of internal medicine residents
This study follows resident doctors in general internal medicine over time to understand their professional and personal experiences, including stress and career growth. It aims to improve support for doctors in training.
BernAges Any age - NCT05734547Recruiting
Support for children after trauma through parent-and-child sessions
This trial offers a structured program for children who have ongoing trauma symptoms after a scary or harmful event, with work involving both the child and a parent/caregiver. It aims to reduce post-trauma stress symptoms and help the child feel safe again.
AskerAges 7–12 - NCT06733883Recruiting
Music therapy for teens with emotional difficulties
This trial tests if music therapy can help adolescents aged 13 to 18 who are struggling with emotional challenges. If you join, you may attend music therapy sessions that could improve how you feel.
Oslo, NydalenAges 13–18 - NCT04276922Recruiting
Creative arts program to reduce healthcare burnout
This study tests a creative arts program to help reduce burnout symptoms in people who work in hospitals. If you’re feeling emotionally drained or disconnected at work, participating may help you build coping and well-being skills.
Aurora, ColoradoAges 18–85 - NCT07538427Recruiting
Music Therapy for Health in Rural Elder Care
This study explores whether music can improve health and wellbeing in older adults living in rural care facilities. Researchers will work with residents to understand how music might help with mood, memory, and quality of life.
Flagstaff, ArizonaAges Any age - NCT07480668Recruiting
Aromatherapy for emotional wellness during IVF
This study tests whether inhaling lavender essential oil can help reduce anxiety, stress, and depression for women waiting for IVF. You may benefit if you are feeling some emotional distress and are not using other mind-body or herbal treatments.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT06633146Recruiting
Stroke rehab in nature settings
This trial tests if stroke recovery exercises in natural environments can help improve your rehabilitation. It is for people who have had a recent stroke.
LahtiAges 18 years+ - NCT07314892Recruiting
Psychiatric health and symptom severity in GvHD patients
This study looks at how graft-versus-host disease (a complication after a bone marrow transplant) affects mental health and symptom severity. It aims to understand the connection so that doctors can better support patients.
Gdansk, Pomeranian VoivodeshipAges 18–75 - NCT07292610Recruiting
Nut study for young university students
This trial tests whether eating nuts regularly can improve mental health in young adults. If you are a university student aged 18-25, you may be able to join.
Cuenca, CuencaAges 18–24 - NCT07250061Recruiting
Self-help PTSD program for women veterans
This study tests a self-guided program to help women veterans with PTSD. You would work through coping skills on your own, with support from a group of other women veterans.
Boston, MassachusettsAges 18 years+ - NCT07227337Recruiting
Being safe, healthy, and empowered for immigrant women
This study tests a program to help immigrant women who have faced violence and feel symptoms of PTSD or depression. It aims to improve your safety, health, and wellbeing.
Baltimore, MarylandAges 18 years+ - NCT07170657Recruiting
Teen Recovery Support Program
This program helps teens ages 15 to 18 who have recently been in the hospital or emergency room for suicidal thoughts or depression. It provides support and guidance to help you recover and feel stronger.
Dallas, TexasAges 15–18
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Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 192 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.