Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07534475Recruiting
Tourniquet Type for Monitoring Brain Activity During ECT
This study compares two types of arm tourniquets (blood-pressure cuffs) used during electroconvulsive therapy (ECT) to help doctors monitor seizure activity more accurately. ECT is a treatment for severe depression and other psychiatric conditions, and tourniquets help track how well the treatment is working.
IstanbulAges 18–65 - NCT07538427Recruiting
Music Therapy for Health in Rural Elder Care
This study explores whether music can improve health and wellbeing in older adults living in rural care facilities. Researchers will work with residents to understand how music might help with mood, memory, and quality of life.
Flagstaff, ArizonaAges Any age - NCT07540585Recruiting
Mental health support for pregnant patients with pregnancy complications
This study tests whether providing mental health care while you're in the hospital for pregnancy-related complications can help you feel better and have better outcomes. It's designed for patients who've had difficulties with past pregnancies.
Indianapolis, IndianaAges 18–100 - NCT06750796Recruiting
Half swaddling study for new mothers and babies
This study tests if half swaddling (wrapping your baby's lower body) helps improve your baby's sleep, your own sleep quality, and your mood. It is for healthy mothers with healthy full-term babies.
Edirne, None SelectedAges 18–45 - NCT07528014Recruiting
Tracking Depression Treatment Outcomes Over Time
This study follows adults receiving depression treatment (esketamine, TMS, or SAINT) to understand how these therapies work and their effects over time. Researchers will assess mood, functioning, and other factors to help improve future treatment.
La Jolla, CaliforniaAges 18 years+ - NCT07523932Recruiting
Digital check-ins after cesarean delivery with a midwife
This study tests whether receiving digital (phone or app) follow-up care from a midwife after cesarean delivery helps with your recovery and your baby's health. You'll be compared to standard care to see if this new approach works well.
GiresunAges 18–45 - NCT07517549Recruiting
Sexual Health Education for Pregnant Women
This study teaches pregnant women about sexual health and wellness during pregnancy. Researchers want to understand how education helps pregnant women and their partners feel more confident about intimacy and health during this time.
Altinordu, OrduAges 18–45 - NCT06705153Recruiting
Laughter yoga for irritable bowel syndrome
This study tests whether laughter yoga can help reduce IBS symptoms like belly pain and bloating, and also improve mood, sleep, and overall quality of life. You would join video calls where you practice special laughing exercises (no jokes needed) and then answer questionnaires.
Erzurum, YakutiyeAges 18–90 - NCT05862636Recruiting
Testing who benefits most from mindfulness meditation
This study looks at people who take part in a mindfulness program at specific study locations and examines who does best. You might be eligible if you are already joining the mindfulness intervention and can complete study tasks in the required language.
AntwerpAges 18 years+ - NCT07512895Recruiting
Muscle Relaxation Exercises for Depression and Fatigue in Dialysis Patients
This study tests whether guided muscle relaxation exercises can reduce depression and tiredness in people undergoing hemodialysis (a blood-filtering treatment). You would learn and practice simple exercises to relax your muscles, which may help improve your mood and energy.
Istanbul, IstanbulAges 18–75 - NCT07511660Enrolling by invitation
Ovarian cell injection for perimenopause symptom relief
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
Monterrey, Nuevo LeónAges 28–70 - NCT07503951Recruiting
Talking therapy for inpatients in psychiatric care
This trial tests whether cognitive behavioral therapy (CBT) works for people staying in a psychiatric hospital. You should be staying for at least three days and able to talk through your thoughts and feelings.
StockholmAges Any age - NCT07499219Enrolling by invitation
Digital help for students waiting for mental health support
This study tests a short digital program for students who are on a waiting list for psychological treatment. It aims to see if the program can provide support while they wait.
Oslo, OsloAges 18–80 - NCT07506148Recruiting
Group ACT vs. Support Group for Student Stress
This study tests a type of talk therapy called Acceptance and Commitment Therapy (ACT) for university students who are feeling depressed or anxious. It compares ACT to a general support group to see which helps more with emotional symptoms.
Montevideo, Montevideo DepartmentAges 18–28 - NCT07504120Recruiting
Home Pilates for people with multiple sclerosis
This study tests whether doing Pilates exercises from home, through online video sessions, can improve physical and mental well-being in people with mild to moderate multiple sclerosis. If you are fairly mobile and not very active, this could be a gentle way to increase exercise and feel better.
Chicago, IllinoisAges 18 years+ - NCT07493317RecruitingPhase 2
Tocilizumab for depression with inflammation
This trial tests a medication called tocilizumab, which targets inflammation, to see if it can improve symptoms of major depression in people with signs of inflammation. You may be eligible if you have depression with a high monocyte count and significant loss of interest or pleasure.
New York, New YorkAges 18–70 - NCT07497347Recruiting
Amino acids and lifestyle for brain aging in older adults
This study tests whether taking a specific amino acid supplement, along with lifestyle changes, can help slow or improve brain aging in older adults who have mild depression. It aims to see if these nutrients can support brain health and mood.
BresciaAges 65–85 - NCT06770075Recruiting
Brightline: testing a wellness app for college students
This study tests a smartphone app that may help students track and improve their mental well-being. Over 6 months, you will wear a device that monitors things like activity and sleep, and use a simple app to check in on your mood. It's designed for full-time undergraduates who do not have a current mental health condition and are not receiving mental health treatment.
SingaporeAges 18–25 - NCT06773338Recruiting
Can playing Tetris improve mental health for migrants?
This study tests if playing the game Tetris can help reduce stress and improve mood for Arabic-speaking immigrants who have applied for asylum. You would play Tetris a few times and report how you feel.
The Hague, NLAges 18 years+ - NCT07483515Recruiting
Bonding before birth: an app for first-time parents
This trial tests a mobile health app for first-time expectant couples to strengthen bonding during pregnancy. It may help reduce stress and improve emotional connection.
SingaporeAges 21–75 - NCT07483034Enrolling by invitation
Music therapy for anxiety during breast cancer treatment
This study tests whether listening to specially chosen music while you're in the hospital for breast cancer treatment can help lower anxiety and depression. It also looks at how music might affect certain substances in your blood that are linked to stress and healing.
Zagreb, City of ZagrebAges 18–65 - NCT06442774Recruiting
Mamaconecta: app support for moms' mental health
This study tests a digital tool called MamaConecta to support mothers' mental health during pregnancy. If you are between 12 and 14 weeks pregnant, speak Spanish, and have a smartphone, you may be able to join.
Barcelona, CataloniaAges 18 years+ - NCT07475039Recruiting
Friendly phone calls to support older adults
This study tests whether a program of friendly phone calls from trained volunteers can help older adults feel more connected and supported. If you are 65 or older and already receive home-delivered meals or other services, you may be able to join.
Gainesville, FloridaAges 55 years+ - NCT07478393Recruiting
Emotion regulation therapy for worry and self-criticism
This trial tests a therapy that helps people manage emotions like worry and self-criticism. It takes place online, so you can join from home in New York.
New York, New YorkAges 18–65
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.