Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07471529Recruiting
Social support app for psychotherapy patients
This trial tests a smartphone app that helps you get social support while you wait for outpatient therapy. It is for people with mild to moderate depression who are not starting therapy right away.
Zurich, Canton of ZurichAges 18–70 - NCT06455527Recruiting
Heart-guided brain stimulation for depression
This trial tests whether a non-invasive brain stimulation technique called tDCS, guided by your heart rate, can help improve depression symptoms. If you have mild to moderate depression and are not on medication, you may be eligible.
New York, New YorkAges 18–65 - NCT07449338Recruiting
Study of accelerated brain stimulation for depression
This trial tests a faster version of a brain stimulation treatment called TMS for people with depression. The goal is to see how well it works and how tolerable it is.
GothenburgAges 18 years+ - NCT07397858Recruiting
Brain stimulation for depression in young people
This study tests if a type of brain stimulation called Transcranial Magnetic Stimulation (TMS) can help treat depression in people aged 15 to 25. It involves a quick, non-invasive treatment that uses magnetic pulses to the head, and researchers want to see how it affects thinking and mood.
Sacramento, CaliforniaAges 15–25 - NCT07420205RecruitingPhase 2
Sleep health study for U.S. Marines
This study looks at the sleep health of active-duty U.S. Marines. If you join, researchers will check your sleep patterns and may offer ways to improve your rest.
San Diego, CaliforniaAges 18 years+ - NCT07415941Recruiting
Mindfulness and nerve stimulation for back pain and depression
This trial tests if combining mindfulness-based meditation with a gentle nerve stimulation device (applied to the ear) can help people aged 50–85 with chronic low back pain and depression. The goal is to reduce pain and improve mood without changing your current medications.
Tallahassee, FloridaAges 50–85 - NCT06578845Recruiting
HappyMums app for depression during pregnancy
This trial tests a mobile app called HappyMums to see if it can help pregnant people who feel depressed or have risk factors for depression. The app is designed to provide support and may improve your mood during pregnancy.
ZagrebAges 18 years+ - NCT06576076Recruiting
Cannabis, emotions, and risk study for teens
This study explores how daily cannabis use affects emotions and risk behaviors in teenagers. You'll answer quick surveys on your phone and wear a Fitbit for up to 3 months.
Boston, MassachusettsAges 12–18 - NCT06888284Enrolling by invitation
Tuijing therapy for depression and heart rate
This trial tests whether Tuijing therapy, a non-invasive treatment, can improve heart rate variability and reduce depression symptoms in people who have been feeling depressed for over three months. It may be an option if you haven't used other treatments recently.
Hong KongAges 18–60 - NCT07376369Recruiting
Spousal support and parenting confidence in new mothers
This study looks at how support from a spouse affects the confidence and mood of first-time mothers. Participants will answer online questionnaires about their experiences.
IstanbulAges 18 years+ - NCT07439744Recruiting
Omega-3 for Depression and Obesity
This study tests whether omega-3 fatty acids can improve depression in people with obesity. It looks at how these healthy fats might reduce inflammation and help mood.
Taichung, TaichungAges 18–54 - NCT07371962Recruiting
Sound Bite: A songwriting program for teens and young adults
This trial tests a therapeutic songwriting program called Sound Bite for people aged 13–24 with mild to moderate depression or anxiety. Participants work with a trained guide to write songs as a way to express feelings and improve mental health.
Kowloon Tong, Hong KongAges 13–24 - NCT07360600Recruiting
Web-based parent support program with coaching
This study tests a web-based program with brief coaching to help parents of children with disabilities manage stress and emotions. Participation involves using the program and talking with a coach, and you must have internet access and a child who visits a clinic regularly.
Tampa, FloridaAges 18 years+ - NCT06985784Recruiting
Virtual reality for head and neck cancer patients and caregivers
This study tests whether using virtual reality can help reduce depression, anxiety, and pain in people with head and neck cancer and their caregivers. You and your caregiver may be able to use VR headsets together as part of your treatment.
Duarte, CaliforniaAges 18 years+ - NCT07599930Recruiting
Novel Snack for Perimenopausal Symptoms and Wellness
This study tests whether a specially designed snack can help reduce hot flashes, night sweats, mood changes, and other symptoms that happen during perimenopause (the years leading up to menopause). You'll eat the snack regularly and answer questions about how you feel.
London, LondonAges 40–55 - NCT07160673Recruiting
Tech-based caregiver break for homebound older adults
This study is testing if a virtual reality (VR) headset or video interaction can give caregivers a short break while the older adult they care for stays safe at home. It aims to reduce caregiver stress and improve well-being for both of you.
Hong Kong, 香港島Ages 18 years+ - NCT05734768Recruiting
Study of anxiety and depression in parents after preterm birth
This study compares how parents feel (anxiety and depression symptoms) after having a baby born preterm versus a full-term baby. It also looks at early “building blocks” of thinking and social development in the child.
ReimsAges 18 years+ - NCT07278752Enrolling by invitation
Social media and emotions in teens study
This study looks at how social media affects teenagers' emotions and daily experiences. Participants will use a smartphone app to track their feelings and social media use over time.
Dallas, TexasAges 13–18 - NCT07341425Recruiting
Focused therapy for stress, anxiety, and depression
This trial tests a short, online therapy program (Focused Acceptance and Commitment Therapy) designed to help you manage stress, anxiety, or depression. You can participate from home using a smartphone, tablet, or computer with a camera.
Aarhus CAges 18 years+ - NCT06512194RecruitingPhase 2
Psilocybin for depression study
This trial tests whether psilocybin can help people with major depression who are currently having a depressive episode. It aims to understand how the treatment works and if it is safe and effective.
Edwards, ColoradoAges 18–70 - NCT07264621Enrolling by invitation
A School Program to Support Behavior and Attendance
This study tests a program to help families and schools work together to support middle school students who've had behavior or attendance challenges. The program involves training for school staff and family participation using text messaging and online tools.
Cottage Grove, OregonAges 11 years+ - NCT07223346Recruiting
Fitness and therapy for Latina cancer survivors
This trial offers a program combining exercise and mental health support for Latina women in Colorado who have recently finished cancer treatment or are still undergoing it. It aims to improve well-being through group sessions focused on physical activity and coping skills.
Fort Collins, ColoradoAges 18 years+ - NCT06528132Recruiting
Mindfulness for older adults with low mood
This trial tests a social worker-led mindfulness program for older adults with mild to moderate depressive symptoms. The goal is to see if it helps improve mood and well-being.
Eastern DistrictAges 60 years+ - NCT07220486Recruiting
Depression support program for nursing home residents and their helpers
This study tests a program for nursing facility residents who have symptoms of depression and their care partners. It aims to provide emotional and practical support during a short stay.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.