Clinical trials
Perinatal Depression clinical trials
Below are recruiting perinatal depression clinical trials, each written for real people, not researchers. We’re tracking 31 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07577947Recruiting
Digital tracking to help treat pregnancy and postpartum depression
This study tests whether wearing an Apple Watch and using a smartphone app can help doctors better understand and treat depression during pregnancy and after birth. You'll receive depression treatment through the study while the app and watch track your daily patterns.
Los Angeles, CaliforniaAges 18 years+ - NCT06968390Recruiting
Faster TMS for depression during pregnancy or after childbirth
This trial tests a faster form of TMS (brain stimulation) for people with depression who are pregnant (14-34 weeks) or within one year of giving birth. It aims to see if the treatment is safe and well-tolerated.
Boston, MassachusettsAges 18–55 - NCT05800509Recruiting
Program for gestational diabetes and low mood in pregnancy
This study offers an intervention program to help people who are diagnosed with gestational diabetes and may also experience depression during pregnancy. It may help improve health during pregnancy and support mood and well-being with smartphone-based participation.
TaipeiAges 20 years+ - NCT06640907Recruiting
Perinatal mental health support for expecting and new mothers
This trial tests a program that provides mental health support to pregnant women and new mothers through their usual healthcare visits. The goal is to see if offering this support as part of routine care can help prevent anxiety and depression.
Mairena del Aljarafe, SevilleAges 18 years+ - NCT06790641Recruiting
Supporting mental health during and after pregnancy
This study aims to improve mental health care for people during and after pregnancy. It involves interviews or focus groups with healthcare providers, peer mentors, and patients to understand how to make support services more helpful and accessible.
Shrewsbury, MassachusettsAges 18–70 - NCT07609550Recruiting
Early mental health support for pregnant and new mothers
This study tests whether connecting pregnant women and new mothers who have depression or anxiety to mental health care earlier helps them. You'll be part of a larger research program and may receive support through a smartphone app.
Mairena del Aljarafe, SevillaAges 18 years+ - NCT07613008Recruiting
Mobile app to prevent perinatal depression and anxiety
This study tests a personalized smartphone app designed to help pregnant women and their partners prevent depression and anxiety during pregnancy and after birth. Participants use the app for support and receive check-ins from healthcare providers.
Mairena del Aljarafe, SevillaAges 18 years+ - NCT07217561Recruiting
Doula support program to improve mental health before and after birth
This trial tests whether extra training and resources for doulas can help pregnant people and new parents feel better emotionally. Doulas who join will learn new ways to support clients, and participants will get care from a trained doula.
Boston, MassachusettsAges Any age - NCT06231602Recruiting
Depression and feeding in new mothers
This study looks at how a mother's mood after giving birth might affect how she feeds her baby. It aims to help first-time mothers get better support.
TaipeiAges 18 years+ - NCT05897619Recruiting
CBT skills app for pregnancy and postpartum stress and coping
This study tests whether a new phone app that teaches “cognitive behavioral therapy” (CBT) skills is helpful and easy to use for people who are pregnant or recently gave birth. It also checks safety and whether participants feel the app is acceptable to use over time.
New York, New YorkAges 18 years+ - NCT04069091Recruiting
Program to help mothers with depression during pregnancy or after birth
This trial studies a maternal depression prevention and early help program for people who screen positive for depression. It may help improve mental health during pregnancy or the postpartum period and support health for both parent and child.
Helsinki, UusimaaAges Any age - NCT06074250RecruitingPhase 2/Phase 3
Pregnancy, mood, and gut health study
This study tests whether a nutritional supplement can help prevent depression and anxiety during and after pregnancy. It looks at how the mother's gut bacteria may influence mood.
Toronto, OntarioAges 18–43 - NCT06383221Enrolling by invitation
Psychological and prenatal support for depression or anxiety in pregnancy
This trial tests a step-by-step program that combines psychological support and prenatal care to help pregnant women manage depression or anxiety. It is designed for women who have screened positive for these symptoms but are not yet receiving treatment.
Ma’anshanAges 18 years+ - NCT06049433Recruiting
Mental health support for new and expecting mothers
This study tests a program to help pregnant women and new mothers who may be at risk for depression after childbirth. The program offers extra support and resources to improve your mental health and well-being.
Salt Lake City, UtahAges 18 years+ - NCT07606248Recruiting
Virtual forest mindfulness for pregnant women's mental health
This study tests whether using virtual reality to explore a calming digital forest helps reduce stress and improve mood during pregnancy. You'd use a VR headset a few times to practice mindfulness (focused breathing and relaxation) and complete short surveys about how you're feeling.
HsinchuAges 18 years+ - NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT07279311Enrolling by invitation
Virtual reality for depression during high-risk pregnancy
This study tests if virtual reality (VR) exercises can help reduce depression symptoms in pregnant people who must stay in the hospital for at least 3 weeks due to complications. If you are feeling down and are able to use VR, this treatment might offer a new way to feel better.
Palo Alto, CaliforniaAges 18 years+ - NCT06363019Recruiting
Support for at-risk mothers during pregnancy
This study offers support for mothers who are going through a tough time during pregnancy or after birth. It is designed to help women who may be financially stressed, single, or dealing with emotional challenges.
SingaporeAges 21–65 - NCT07607613Recruiting
Support for LGBTQ+ Parents with Depression Risk
This study offers group support sessions for LGBTQ+ parents who are pregnant or recently had a baby and are experiencing mild depression or worry about postpartum depression. The goal is to help prevent depression from getting worse and improve emotional well-being during this important life transition.
Chicago, IllinoisAges 18 years+ - NCT05710991Recruiting
Brief therapy for sleep trouble in early pregnancy
This trial compares two short approaches to help with insomnia (sleep difficulties) during early pregnancy: brief cognitive behavioral therapy or sleep hygiene tips. It may help improve how well you sleep without using new or changing medications.
Hamilton, OntarioAges 18–45 - NCT06473935Recruiting
Maternal well-being study for first-time mothers
This study follows first-time mothers from the last months of pregnancy until 18 months after childbirth to understand and support maternal well-being. You will be asked to fill out questionnaires and attend check-ins during this time.
MilanAges Any age - NCT06364488Recruiting
App for monitoring depression and anxiety in pregnancy
This trial tests a mobile app called TrueBlue to help monitor depression and anxiety in new and expecting mothers. If you are pregnant or recently gave birth, the study will see if the app can make tracking your moods easier and connect you with care.
Nottingham, NottinghamshireAges 18 years+ - NCT06881693Recruiting
Online CBT for depression and anxiety in new parents
This study tests an internet-based cognitive behavioral therapy (CBT) program for parents who are expecting or have a new baby (up to 2 years old) and are struggling with depression or anxiety. It's designed to help you learn skills you can use at home, on your own schedule.
Regina, SaskatchewanAges 18 years+ - NCT05961306Recruiting
Testing a stepped screening plan during pregnancy and after birth
This study checks how well a step-by-step screening approach and its tools work for identifying issues during pregnancy (weeks 20–24) or in early postpartum (6–10 weeks after delivery). It may help doctors use more accurate screening to decide who needs further care.
Ghent, Oost-VlaanderenAges 18 years+
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Perinatal Depression trials by city
Studies with a site in or near these metro areas.
Perinatal Depression trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for perinatal depression?
- Yes. Clin2 currently lists 31 recruiting perinatal depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a perinatal depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a perinatal depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.