Clinical trials
General Population (no Specific Condition or Disease) clinical trials
Below are recruiting general population (no specific condition or disease) clinical trials, each written for real people, not researchers. We’re tracking 10,808 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05066711Enrolling by invitation
Study of a neck surgery implant for adults
This trial looks at using a specific implant system during planned front-of-the-neck surgery (C2 to C7) for common neck problems like disc degeneration, injury, or spinal narrowing. It may help doctors compare outcomes with this particular hardware and surgical approach.
Naperville, IllinoisAges 18 years+ - NCT04994847Enrolling by invitation
Study APOE-related brain changes to help prevent Alzheimer’s
This study looks at how a person’s APOE gene relates to early brain and health changes that could lead to Alzheimer’s. If you are not currently having memory or thinking problems, you may be asked to do brain scans, cognitive testing, and blood plus a spinal fluid sample to support research.
Phoenix, ArizonaAges 50–90 - NCT04961450Enrolling by invitation
Study tracking brain illness markers in motor neuron and frontotemporal disease
This study looks for “biomarkers” (measurable signs in blood or other samples) in people with motor neuron disease and frontotemporal dementia spectrum conditions. It also compares those findings with matched caregivers, to understand what might be happening in these diseases.
Beijing, Beijing MunicipalityAges 18–80 - NCT04866459Enrolling by invitation
Myo-MRI scan study for neuromuscular muscle diseases
This study tests whether special MRI scans can help evaluate neuromuscular (muscle/nerve) diseases. It may help doctors better assess muscle involvement and support diagnosis and evaluation.
Ottawa, OntarioAges 18 years+ - NCT04833907Enrolling by invitationPhase 1/Phase 2
Gene therapy study for typical Canavan disease in children
This early-phase trial tests a gene therapy medicine (delivered by a one-time infusion) for children with typical Canavan disease. It aims to improve safety and help evaluate whether the treatment may benefit children over time.
Dayton, OhioAges 3 months–5 years - NCT04734626Enrolling by invitation
Leg MRI study for mitochondrial muscle weakness
This study uses an MRI scan of the lower leg to look for signs of muscle problems in people with suspected or confirmed mitochondrial disease, and compares them with healthy volunteers. Participants will lie still in the MRI and do a short, mild exercise during the scan to help the researchers see how muscles work.
Philadelphia, PennsylvaniaAges 7–75 - NCT04628585Enrolling by invitation
Follow-up for people with sickle cell treated with gene therapy
This study is a long-term follow-up for people who already received gene therapy for sickle cell disease in a specific sponsor’s clinical trial. It helps researchers watch for long-term safety and outcomes over time.
Birmingham, AlabamaAges 2–53 - NCT04607369Enrolling by invitation
Test using an app to map eye vision blind spots
This trial tests how well an EyeCTester smartphone app can measure vision blind spots and distorted vision compared with standard eye tests. If you qualify, you’ll do short near-vision and “Amsler grid” style tasks in the clinic to help confirm the app is accurate.
Bellaire, TexasAges 18 years+ - NCT04451044Enrolling by invitation
Guided heart stent planning using an inside pressure sensor
This study tests whether using a tiny pressure sensor in heart arteries during a procedure can better guide where to place a stent. It may help doctors choose the safest and most effective stent plan by more accurately measuring artery narrowing.
Birmingham, AlabamaAges 18 years+ - NCT04450927Enrolling by invitation
Collecting health data from NHLBI patients and donors
This study collects information about standard care for people seen by the NHLBI, and also about donors. It helps researchers understand what happens in real-world care, which can improve future treatment decisions.
Bethesda, MarylandAges 2–120 - NCT04343417Enrolling by invitation
Kidney biopsy study that stores samples for research
This study collects and stores kidney biopsy samples (and related information) to help researchers understand kidney diseases. You may be able to join if you are already scheduled for a kidney biopsy and can consent.
New Haven, ConnecticutAges 18–99 - NCT04234139Enrolling by invitation
Study of severe alcoholic hepatitis patients before early liver transplant
This study follows people with severe alcoholic hepatitis who are being considered for an early liver transplant before they’ve been sober for 6 months. It aims to better understand this group’s situation and ethics/safety as early transplantation plans are made.
Baltimore, MarylandAges 18 years+ - NCT04190758Enrolling by invitation
Early arthritis study for RA, psoriatic arthritis, and psoriasis
This study looks at people with early arthritis related to rheumatoid arthritis, psoriatic arthritis, or psoriasis. Researchers want to understand how these early conditions behave and may help guide better treatment decisions.
GothenburgAges 18–80 - NCT04042532Enrolling by invitation
Theta-burst brain stimulation for younger-onset Alzheimer’s
This trial tests whether a form of brain stimulation (theta-burst stimulation) can improve thinking and memory in people with younger-onset Alzheimer’s. It also compares results with people without dementia who meet similar age and health requirements.
Taoyuan, GuishanAges 50–75 - NCT03901521Enrolling by invitation
Biobank for people with autosomal dominant polycystic kidney disease
This study collects samples and health information from adults with autosomal dominant polycystic kidney disease (ADPKD) who are having their own kidney removed. It helps researchers learn more about ADPKD and its genetic changes to support future treatments.
New York, New YorkAges 18–100 - NCT03862274Enrolling by invitation
Study of development in children with CLN2 due to TPP1 changes
This study looks at how children’s development progresses in CLN2 disease caused by a specific enzyme problem (TPP1). It may help doctors better understand outcomes and guide future care for children with this diagnosis.
Columbus, OhioAges Any age - NCT03692455Enrolling by invitation
Compare two weight-loss surgeries for reflux over 8 years
This study follows people for up to 8 years to see how two different weight-loss surgeries affect ongoing heartburn and acid reflux. You would join only if you were already enrolled in an earlier related study and can complete required follow-up visits and tests.
Passo Fundo, Rio Grande do SulAges 18–78 - NCT03674255Enrolling by invitation
Tests how accurate heart ultrasound is during stress
This study checks how well a heart ultrasound (echocardiography) works when your heart is at rest and under stress. You may benefit by getting closer attention to how the test is done, especially if it’s being used to look for blocked-heart-blood-flow problems.
Ages 18 years+ - NCT03623672Enrolling by invitation
Study for early signs of Parkinson-related brain changes
This study enrolls people with idiopathic REM sleep behavior disorder, a sleep problem that can come before Parkinson’s disease or related conditions. It aims to better understand early (“prodromal”) changes so future treatments can be targeted earlier.
Sun City, ArizonaAges 18 years+ - NCT03582488Enrolling by invitationPhase 4
Tracking brain changes in probable Lewy body dementia
This trial follows people with probable Lewy body dementia over several years to see how the brain changes on MRI and on memory/thinking tests. It may help researchers understand disease progression and improve future care for Lewy body dementia.
Jacksonville, FloridaAges 18 years+ - NCT03395509Enrolling by invitation
Free screening program for diabetes and heart risks
This study looks at how well and how cost-effective a combined health screening is for diabetes and cardiovascular (heart and blood vessel) risks. You may be invited to attend screening around your 67th birthday.
ViborgAges 67–67 - NCT03319446Enrolling by invitation
Sharing anonymous samples for a diagnostic test
This trial collects and stores anonymous samples from consenting adults. It helps researchers evaluate or improve diagnostic testing without using your personal identity.
Salt Lake City, UtahAges 18–99 - NCT03295279Enrolling by invitation
Use of chest CT scans from WTC Health Plan participants
This study creates a research archive of chest CT scan images from people enrolled in the World Trade Center (WTC) Health Plan program at Mount Sinai. It may help doctors and researchers better understand and track chest health over time using existing scan images.
New York, New YorkAges 18 years+ - NCT03162549Enrolling by invitation
Inflammatory bowel disease registry for adults on biologics or JAKs
This study is a real-world registry that collects information about people with Crohn’s disease or ulcerative colitis who take certain medicines (biologics or tofacitinib). It helps researchers better understand how these treatments are used and how people are doing over time.
Waltham, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for general population (no specific condition or disease)?
- Yes. Clin2 currently lists 10,808 recruiting general population (no specific condition or disease) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a general population (no specific condition or disease) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a general population (no specific condition or disease) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.