Clinical trials
Generalized Anxiety Disorder clinical trials
Below are recruiting generalized anxiety disorder clinical trials, each written for real people, not researchers. We’re tracking 132 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04557891RecruitingTeam says not enrolling
Low-intensity ultrasound for generalized anxiety disorder
This trial tests a non-drug brain treatment using low-intensity focused ultrasound to reduce symptoms of generalized anxiety disorder (GAD). It may help if your anxiety has been moderate to severe and you’ve already tried standard medications without enough relief.
Los Angeles, CaliforniaAges 18–65 - NCT07774481Recruiting
Anxiety skills study for Ohio residents
This study tests an anxiety management program that you can use on your smartphone. It aims to help reduce anxiety symptoms and improve daily functioning.
Columbus, OhioAges 18 years+ - NCT06701903RecruitingPhase 2
Study of an investigational drug for generalized anxiety disorder
This study tests an investigational oral medication (ITI-1284) for people with moderate to severe generalized anxiety disorder (GAD) who haven't found enough relief from at least two standard medications. The goal is to see if this new drug helps reduce anxiety symptoms.
Birmingham, AlabamaAges 18 years+ - NCT07489651RecruitingPhase 2
New treatment for generalized anxiety disorder
This trial tests a new medication called RE104 for people with generalized anxiety disorder (GAD). The goal is to see if it helps reduce anxiety symptoms safely.
Birmingham, AlabamaAges 18–74 - NCT07382323Recruiting
Comparing two talk therapies for anxiety and PTSD
This trial tests two types of therapy — metacognitive therapy and cognitive-behavioral therapy — to see which works better for people with certain anxiety disorders or PTSD. You would be randomly assigned to one of the treatments and attend regular sessions.
StockholmAges 18 years+ - NCT06480383RecruitingPhase 2
Adding an experimental pill to current anxiety medication
This study tests an experimental medication (ITI-1284) added to your current anxiety treatment to see if it improves symptoms. It's for adults with generalized anxiety disorder (GAD) who haven't gotten enough relief from their current medicine.
Glendale, CaliforniaAges Any age - NCT07767903RecruitingPhase 3
Study of a new medicine for generalized anxiety disorder
This trial tests an investigational medication to see if it can reduce anxiety symptoms in adults with generalized anxiety disorder. Participants will receive the study drug and be monitored for safety and effectiveness.
Cherry Hill, New JerseyAges 18 years+ - NCT07759128RecruitingPhase 3
Test of a new anxiety medication for adults with generalized anxiety disorder
This study tests a new medicine (SEP-363856) for adults with generalized anxiety disorder to see if it reduces anxiety symptoms and is safe. It may help if other treatments haven't worked well.
Jacksonville, FloridaAges 18 years+ - NCT06969170RecruitingPhase 2
Psilocybin oral solution for generalized anxiety disorder trial
This study tests a psilocybin oral solution in adults with generalized anxiety disorder (GAD). It aims to see if the drug is safe, tolerable, and helpful for reducing anxiety symptoms.
Kingston, OntarioAges 18–60 - NCT07753330Recruiting
Anxiety treatment study
This study tests a new type of therapy that focuses on facing fears to help reduce anxiety. It may be a good fit if you have an anxiety disorder and are looking for treatment.
Santiago, Santiago MetropolitanAges 18–70 - NCT06934525Recruiting
Team therapy for childhood anxiety and OCD
This study tests a team-based therapy approach for children and teens with anxiety or OCD. It helps families get treatment in community mental health centers, not just in specialized clinics.
East Providence, Rhode IslandAges 5–18 - NCT05671419Recruiting
Mindful self-compassion training for anxiety and depression
This study tests whether a structured “mindful self-compassion” program can reduce symptoms of anxiety disorders or depression. It’s meant to help by improving how you relate to yourself during difficult thoughts and feelings.
Washington D.C., District of ColumbiaAges 18–75 - NCT05683223Recruiting
Brain and body markers to improve treatment for social anxiety
This study uses brain recordings (EEG and MRI) to understand how treatments help people with social anxiety. It also looks for signals that may predict who is most likely to benefit from treatment.
Boston, MassachusettsAges 18–50 - NCT04221997RecruitingPhase 4
Sertraline study for anxious children and teens
This trial tests whether sertraline (an anti-anxiety medicine) helps children and teens with generalized, separation, and/or social anxiety disorders. It also includes healthy children/teens for comparison so researchers can better understand safety and symptoms over time.
Cincinnati, OhioAges 8–17 - NCT04702711Recruiting
Study of anger feelings in people with generalized anxiety
This trial studies how anger shows up in people who have symptoms of generalized anxiety. The goal is to learn more about these experiences in primary care, which could improve how care is tailored.
VaxjoAges 18 years+ - NCT04793828Recruiting
Self-guided online program for certain anxiety disorders
This trial tests “Velibra,” a self-guided online program to help people with anxiety disorders while they are waiting for care. It focuses on panic, social anxiety, and generalized anxiety, and may help by teaching coping skills through lessons and questionnaires.
BerlinAges 18–65 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+ - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT05117255Recruiting
Online therapy study for anxiety in residential alcohol treatment
This study tests an internet-based, interactive version of cognitive behavioral therapy (CBT) for anxiety symptoms. It’s designed for people getting mainly alcohol-focused treatment in a residential program, to see if the online approach works and is feasible for you.
Minneapolis, MinnesotaAges 18–65 - NCT05393518Recruiting
Study linking brain signals to anxiety in people with epilepsy
This study looks at how brain electrical signals relate to anxiety symptoms in people with drug-resistant epilepsy. It compares people who do (or do not) meet criteria for generalized anxiety disorder, to better understand anxiety in this setting.
BordeauxAges 18–65 - NCT05427708Recruiting
Breathing training to reduce anxiety symptoms
This study tests whether specific respiratory (breathing) training can reduce anxiety symptoms and fear responses. It may help people who have several kinds of anxiety or trauma-related anxiety, especially if they are not on anxiety medicines or only stable on them.
Austin, TexasAges 18 years+ - NCT05467683Recruiting
Breathing CO2 test to predict which anxiety therapies won’t work
This study uses a controlled breathing test (inhaling CO2 or breathing faster) to see if it can predict whether exposure-based therapy will help your anxiety disorder. If you are in the right group, the results may help doctors choose more effective treatment earlier.
Boston, MassachusettsAges 18–70 - NCT05527509Recruiting
Study of risk and resilience in new RCMP cadets
This study follows people as they start RCMP Cadet Training to learn what factors affect “risk” and “resilience” (how well someone adapts under stress). It may help improve support for cadets during training.
Regina, SaskatchewanAges 19–57
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Generalized Anxiety Disorder trials by city
Studies with a site in or near these metro areas.
Generalized Anxiety Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for generalized anxiety disorder?
- Yes. Clin2 currently lists 132 recruiting generalized anxiety disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a generalized anxiety disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a generalized anxiety disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.