Clinical trials
Gingivitis and Periodontal Diseases clinical trials
Below are recruiting gingivitis and periodontal diseases clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06958874Recruiting
Erythritol for gum pocket healing
This study tests if adding erythritol to standard gum treatment helps close deep gum pockets in people with advanced gum disease (periodontitis).
L’AquilaAges 35 years+ - NCT07421960Recruiting
Periodontitis and sleep quality study
This study looks at how gum disease (periodontitis) might be related to sleep quality. It compares people with healthy gums to those with gum disease.
Istanbul, IstanbulAges 18–65 - NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40 - NCT07306026Recruiting
Testing a toothbrush's bristles on plaque and gums
This trial compares how well different toothbrush bristles remove plaque and affect gum health. It may help find the best toothbrush design for everyday oral care.
Buffalo, New YorkAges 18–70 - NCT07205172Recruiting
Gum looks and teeth crowding in children
This study looks at how the appearance of the gums relates to crowding of teeth in children. It will examine kids in different stages of tooth development to see if there is a link.
RomaAges 5–16 - NCT06745141Recruiting
Gum disease treatment after a heart attack
This trial tests whether treating severe gum disease can improve recovery after a heart attack (STEMI). If you recently had a heart attack and also have serious gum problems, you may be able to join and receive periodontal care.
Shanghai, Shanghai MunicipalityAges 30 years+ - NCT07258303Recruiting
Probiotic Spray for Gum Disease in Older Adults
This trial tests an oral spray that contains good bacteria (probiotics) to help prevent and treat gum disease in older adults. It may be a simple addition to your daily routine to support gum health.
Hanoi, HanoiAges 35 years+ - NCT06882564RecruitingPhase 3
Resveratrol mouthwash for bad breath study
This trial tests whether a special mouthwash with resveratrol (a natural plant compound) can help reduce bad breath caused by gum-related bacteria. It might be a good option if you have bad breath from gingivitis (mild gum inflammation) and are a non-smoking dental student.
Baghdad, Bab Al-MoadhamAges 20–24 - NCT07424846RecruitingPhase 2/Phase 3
Xylitol gum to prevent gum disease and early birth
This trial tests if chewing xylitol gum during pregnancy can reduce gum disease and preterm birth. You would chew gum after meals and attend dental visits and follow-ups.
LilongweAges Any age - NCT07377344Recruiting
Gum health care during pregnancy
This trial tests ways to improve gum health during pregnancy. If you have gum disease or are at risk, the study may provide dental care that could help both you and your baby.
San Francisco, CaliforniaAges 18 years+ - NCT07185191Recruiting
Device to treat gum shrinkage and black triangles between teeth
This trial tests a medical device (RDM36) to see if it safely and effectively treats gum shrinkage and black triangles between the front teeth, which can affect your smile.
Brescia, ItalyAges 18 years+ - NCT07739732Recruiting
Gum disease mouth fluid study
This study compares the chemicals in the fluid around teeth between people with gum disease and healthy people. The goal is to find changes that could help understand or detect gum disease.
Catania, ItalyAges 18–70 - NCT07549347Recruiting
Smart Toothbrush vs. Professional Cleaning for Gum Disease
This study tests whether using an intelligent (electric) toothbrush with a smartphone app can manage early gum inflammation as effectively as professional dental cleaning. If you have mild gum disease, this trial may help you avoid or delay professional treatments.
Shanghai, Shanghai MunicipalityAges 18–64 - NCT07666126Recruiting
Uric acid and gum bone health study
This study looks at whether high uric acid levels affect the bone around your teeth. If you are between 18 and 65, have at least 20 natural teeth, and are either healthy or have high uric acid and gum disease, this trial may be for you.
RizeAges 18–65 - NCT07167771Recruiting
Saliva markers for gum disease: a follow-up study
This study follows up with people who already took part in a previous saliva and gum health study. Researchers want to see if certain substances in saliva can predict gum disease progression over time.
MadridAges 18 years+ - NCT06875440Enrolling by invitation
Green tea vs. chlorhexidine mouthwash for gum disease
This trial tests if green tea mouthwash works as well as a standard mouthwash (chlorhexidine) for treating gum inflammation. It also checks how the mouthwash affects certain cells and chemicals in your spit that are linked to gum health.
Tehran, Tehran, Iran.Ages 18–40 - NCT07518901Enrolling by invitationPhase 4
New Nanoparticle Treatment for Root Canal Therapy
This study tests a new type of nanoparticle (tiny medical particles) called Ferumoxytol to help treat infected tooth roots. Researchers want to see if this approach works better than standard root canal treatments.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07169305Recruiting
Study on filling placement depth and tooth health
This trial tests how the depth of a filling below the gumline affects the health of the tooth's nerve and surrounding gum tissue. It may help people with cavities that go below the gum to get better care.
Rohtak, HaryanaAges 18 years+ - NCT07755800Enrolling by invitation
Arginine toothpaste for gum health in periodontitis patients
This study tests whether an arginine-containing toothpaste improves gum health in people with treated periodontitis during their maintenance care. It may reduce gum inflammation and promote better bacterial balance below the gumline.
Iowa City, IowaAges 18–95 - NCT06900881RecruitingPhase 2/Phase 3
Kefir Mouthwash for Healthy Gums
This clinical trial tests if a mouthwash made from kefir, a fermented milk drink, can reduce gum swelling and bleeding (gingivitis) in young adults. You might benefit if you have mild gum disease but are otherwise healthy.
BaghdadAges 18–28 - NCT06012019Recruiting
Gum Disease and Inflammation Study
This study looks at gum disease (periodontitis and gingivitis) and inflammation using blood and dental samples. It may help researchers understand how inflammation affects gum health.
Ivry-sur-SeineAges 18 years+ - NCT07491627Enrolling by invitation
Nicotine's effect on gum disease treatment in smokers and non-smokers
This study looks at how smoking and nicotine affect the success of gum disease treatment. It compares results between smokers and non-smokers who have gum disease.
Liège, LiegeAges 18 years+ - NCT07487272Recruiting
Cell mapping in gum disease tissues
This study looks at the cells in gum tissue from people with different types of periodontitis (aggressive or chronic) and healthy gums. By understanding which cells are active and how they interact, researchers hope to find better ways to diagnose or treat gum disease.
Hangzhou, ZhejiangAges 20–40 - NCT07611461Enrolling by invitation
How Dental Crowns Affect Gum Health Long-Term
This study follows patients who receive tooth-colored metal crowns to see how these dental restorations affect the health of gums and supporting tissues over time. Understanding this helps dentists place crowns in ways that keep your mouth healthiest.
Riga, Dzirciema Iela 20Ages 20–75
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Common questions
- Are there clinical trials for gingivitis and periodontal diseases?
- Yes. Clin2 currently lists 54 recruiting gingivitis and periodontal diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gingivitis and periodontal diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gingivitis and periodontal diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.