Clinical trials
Human Papillomavirus clinical trials
Below are recruiting human papillomavirus clinical trials, each written for real people, not researchers. We’re tracking 66 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06254911RecruitingPhase 2
Immunotherapy before surgery for HPV-related throat cancer
This trial tests whether giving the drug atezolizumab before surgery can help shrink HPV-related throat cancer and improve outcomes. Atezolizumab helps your immune system fight cancer cells.
Atlanta, GeorgiaAges 18 years+ - NCT06254846Recruiting
Urine test for HPV cervical cancer screening
This study tests if a urine sample can replace a cervical swab for HPV testing during cervical cancer screening. If it works, it could make screening easier and less uncomfortable.
Saint-EtienneAges 30–65 - NCT05799144RecruitingPhase 2
Pembrolizumab plus investigational HPV drugs for throat cancer
This Phase 2 trial studies pembrolizumab (an immune therapy) combined with investigational treatment(s) pBI-11 and TA-HPV for advanced or recurrent oropharyngeal cancer that is HPV-positive and has certain immune marker levels (PD-L1 CPS ≥ 1). It may help your immune system better attack cancer.
Birmingham, AlabamaAges 18 years+ - NCT05774561Recruiting
Using blood tests to monitor HPV-related cancer treatment
This study checks whether “liquid biopsies” (blood tests that look for cancer-related signals) can help monitor how HPV-related cancers respond to treatment. It may help doctors spot changes earlier during care.
OlomoucAges 18–99 - NCT05686226RecruitingPhase 2
Trial tests immune cells targeting HPV-16 cancers
This Phase 2 trial tests an immune-cell treatment (E7 TCR T cells) designed to attack cancers caused by HPV type 16. It may help people whose HPV-16+ cancer has come back or not responded to standard treatment.
Bethesda, MarylandAges 18 years+ - NCT05672927RecruitingPhase 4
Comparing HPV vaccine schedules: 2 doses vs 3 doses
This study compares how well your immune system responds to an HPV vaccine given as either 2 doses or 3 doses in people ages 27–45 who have never had the HPV vaccine. It may help improve HPV prevention strategies and guide the best dose schedule for adults.
Galveston, TexasAges 27–45 - NCT05539638Recruiting
Testing blood DNA for head and neck squamous cancer
This study looks at how tumor DNA found in a blood sample (a “DNA signal”) relates to head and neck cancer in the oropharynx. It may help doctors understand disease status and improve how they monitor treatment, for both HPV-positive and HPV-negative cancers.
Dundee, DD2 1SGAges 18 years+ - NCT05026138Recruiting
Study of severe HPV disease and why it keeps coming back
This study follows people with severe or hard-to-treat HPV-related conditions (and some closely related partners/household contacts) to learn how the virus causes illness and how the immune system responds. It may help doctors better predict who will develop severe disease and guide future treatments.
Bethesda, MarylandAges 3–100 - NCT04226313Recruiting
Home self-swab tests for people not doing cervical screening
This study looks at whether a home self-sampling swab can help people who haven’t joined cervical cancer screening in the past few years. If you qualify, you’ll be asked to collect a swab yourself so it can be tested, aiming to make screening easier to access.
OlomoucAges 30–65 - NCT04131413RecruitingPhase 1
HPV vaccine given through the skin for HPV16 cervical disease
This early-phase study tests a vaccine designed to help your immune system fight HPV16, a type of human papillomavirus linked to abnormal cells in the cervix. You may or may not be living with HIV, and the team will check safety and immune response after giving the vaccine in a specific way.
Birmingham, AlabamaAges 19 years+ - NCT07104240Recruiting
Improving HPV vaccination for preteens ages 9-12
This study tests a program designed to help primary care practices increase HPV vaccination rates among adolescents aged 9 to 12 who haven't yet been vaccinated. It aims to find out if providing practices with resources and support can lead to more kids getting the HPV vaccine.
Atlanta, GeorgiaAges 9 years+ - NCT06926062Recruiting
Improving HPV vaccine communication in pharmacies
This study looks at whether training pharmacy staff in communication and vaccination workflows can improve HPV vaccine recommendations and uptake. If you are a parent or guardian of a child aged 9–17 who has not yet completed the HPV vaccine series, you may be eligible to participate.
University Park, PennsylvaniaAges 18 years+ - NCT06821243Recruiting
Finding markers in HPV-related throat cancer to guide treatment
This study looks for certain markers in people with HPV-related throat cancer that could help doctors choose the best treatment. If you are planning to have surgery for your throat cancer, you may be able to join.
Rome, RomeAges 18 years+ - NCT06636734RecruitingPhase 2
Lovastatin plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding lovastatin (a cholesterol-lowering drug) to pembrolizumab (an immunotherapy) works better than pembrolizumab alone for head and neck cancer that has come back or spread. It's for people who haven't had immunotherapy before and aren't already on a statin.
Atlanta, GeorgiaAges 18 years+ - NCT06115772Recruiting
HPV and genital health in women with HPV-positive throat cancer
This study looks at HPV-related health in the genital and anal areas of women who have HPV-positive oropharyngeal cancer, or are the female partners of someone who does. The goal is to better understand how HPV affects these areas over time.
Rochester, MinnesotaAges 18 years+ - NCT05600842Recruiting
Lower-dose radiation for HPV-positive throat cancer
This trial tests whether using a de-escalated (lower/intensity-reduced) radiation approach can treat HPV-positive oropharyngeal squamous cell carcinoma. It may help reduce side effects while still keeping the cancer under control.
Orange, CaliforniaAges 18 years+ - NCT05541016RecruitingPhase 2
Personalized lower-dose radiation for HPV-related throat cancer
This Phase 2 study tests whether giving a less intense (de-escalated) radiation plan can work for certain people with HPV-related oropharyngeal throat cancer. It uses HPV blood testing and scans to help guide treatment, aiming to keep cancer control while reducing treatment side effects.
Scottsdale, ArizonaAges 18 years+ - NCT05046080Recruiting
Testing after diagnosis of clear cell cervical cancer
This study is for people who have been diagnosed with clear cell cancer of the cervix. It looks at cancer tissue and related lab tests to better understand the disease and possibly guide care decisions.
Houston, TexasAges Any age
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Common questions
- Are there clinical trials for human papillomavirus?
- Yes. Clin2 currently lists 66 recruiting human papillomavirus studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a human papillomavirus trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a human papillomavirus trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.