Clinical trials
Joint Replacement clinical trials
Below are recruiting joint replacement clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01909375Recruiting
Joint replacement registry study for people getting new joints
This is a registry study that collects information about people in the US who are getting a total joint replacement. It may help researchers understand outcomes and improve care for patients like you.
Rosemont, IllinoisAges Any age - NCT03328611Recruiting
Joint replacement outcomes database for degenerative joint disease
This study collects information about people with “wear-and-tear” joint disease who need joint replacement. The goal is to better understand outcomes after surgery and improve future care.
Indianapolis, IndianaAges Any age - NCT07723352Enrolling by invitation
Testing Journavx for Thumb Arthritis Surgery Pain
This trial tests a new pain medicine called Journavx (suzetrigine) for people having thumb arthritis surgery. It aims to see how well the medicine controls pain after the operation.
Philadelphia, PennsylvaniaAges 40–80 - NCT07281885Recruiting
Aromatherapy for nausea after joint replacement
This study tests whether aromatherapy with essential oils can help reduce nausea and vomiting after total joint replacement surgery. Participants will receive a simple aromatherapy treatment alongside their regular care.
Wong Tai Sin, Hong KongAges 18 years+ - NCT06126614RecruitingPhase 3
Infection prevention in joint replacement surgery
This trial tests a way to prevent infections for people getting a hip or knee replacement. It compares different methods to see which works best and may help lower your risk of infection after surgery.
Hamilton, OntarioAges 18 years+ - NCT03991728Recruiting
TMJ implant registry for adults with a new jaw joint replacement
This registry is for adults getting an artificial (alloplastic) full replacement of the jaw joint (TMJ). It collects real-world information about your implant and care to help improve future outcomes.
São PauloAges 18 years+ - NCT07373184Recruiting
Virtual planning for jaw joint replacement
This study looks back at past jaw joint (TMJ) replacement surgeries to see how virtual planning helped. If you already had this surgery at a specific hospital between 2010 and 2025, you might be included.
LundAges Any age - NCT06091397Recruiting
Italian ankle replacement survey study
This study tests a new Italian questionnaire for people who have had total ankle replacement surgery. It helps doctors understand how well patients forget about their new ankle in daily life.
BolognaAges 25–80 - NCT07569549Recruiting
Thumb Base Surgery: Joint Replacement vs. Removal Comparison
This study compares two surgical approaches for thumb base arthritis: replacing the damaged joint with an implant or removing the problematic bone. Researchers want to see which approach works better for pain relief and hand function.
ÖrebroAges 40–80 - NCT07333560Recruiting
Predicting recovery after hip or knee replacement
This study is developing a tool that uses machine learning to predict how well you will recover after hip or knee replacement surgery. It aims to help doctors create better recovery plans for people like you.
BolognaAges 18 years+ - NCT06687109Recruiting
Joint replacement surgery registry study
This study collects information from people having joint replacement surgery to track how they do over time and improve care.
Spokane, WashingtonAges 18 years+ - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT07404982RecruitingPhase 2
Speeding Recovery from Spinal Anesthesia After Joint Surgery
This trial tests a way to make the leg numbness and weakness from spinal anesthesia wear off faster after joint replacement surgery. Researchers use a small tube (catheter) placed in your spine during the procedure to reverse the muscle block sooner.
Boston, MassachusettsAges Any age - NCT07330011Recruiting
Study on measuring patient assistance after joint surgery
This study tests if training staff improves how they measure the level of help patients need after hip or knee surgery. It may help standardize care for these patients.
BolognaAges 18 years+ - NCT07348627RecruitingPhase 3
Opioid-free hip replacement study
This trial tests if using fewer opioids after hip replacement surgery can still control pain well. It uses a specific type of hip replacement called anterior total hip arthroplasty and aims to help patients recover with less reliance on strong pain medicines.
Atlanta, GeorgiaAges 18 years+ - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT07473089Recruiting
Swiss study on joint replacement revision for infection
This study looks at people who need a second (revision) surgery on a large joint replacement like a hip, knee, shoulder, ankle, or elbow because of a suspected or confirmed infection. The goal is to learn more about these infections and improve care.
AarauAges 18 years+ - NCT05805774Recruiting
Compare fixing versus replacing a fractured thigh bone
This study looks at the best surgical option for an acute (new) fracture of the lower thigh bone near a stable knee replacement. It compares surgery that “fixes” the bone versus surgery that “replaces” part of the bone to help you walk again safely.
Toronto, OntarioAges 65 years+ - NCT07016243Recruiting
Knee recovery and ankle movement after knee replacement
This study looks at how well patients can move their ankle after knee replacement surgery and whether it affects their knee recovery. It may help improve rehabilitation for future patients.
Bagheria, PalermoAges 65–85 - NCT05169229RecruitingPhase 2
Antibiotic bone graft to prevent infection in hip replacement
This trial tests whether adding antibiotics to the bone graft used during hip replacement surgery can lower the risk of infection. It may help people who need a bone graft as part of their hip replacement.
Linköping, Region ÖstergotlandAges 18 years+ - NCT07178223Recruiting
Thumb base replacement surgery for arthritis
This study tests a new type of thumb joint replacement surgery for people with arthritis at the base of the thumb. The goal is to see if it relieves pain and improves function better than current treatments.
StockholmAges Any age - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT05357378Recruiting
Hip replacement study using a reverse hip implant
This trial looks at how safe and well a specific “reverse” hip implant works in people who need their first total hip replacement. It may help by improving pain and hip function, while closely tracking safety during and after surgery.
Miami, FloridaAges 50–75
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Common questions
- Are there clinical trials for joint replacement?
- Yes. Clin2 currently lists 25 recruiting joint replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a joint replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a joint replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.