Clinical trials
Total Knee Replacement clinical trials
Below are recruiting total knee replacement clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04275362Recruiting
Walking analysis after a specific knee replacement design
This study looks at how people walk after receiving a particular total knee replacement design. It compares movement patterns (gait analysis) to help understand how well the knee works in real life.
Phoenix, ArizonaAges 50 years+ - NCT04858347Recruiting
Study of a specific knee implant and recovery outcomes
This trial looks at how well a particular knee replacement (a GEMINI SL fixed-bearing prosthesis) works and how people function after surgery. It may help doctors learn what to expect for recovery and long-term results with this implant.
Cali, Valle del Cauca DepartmentAges 18–80 - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT07864896RecruitingPhase 3
Study of a new pain medicine after knee replacement surgery
This trial tests a new oral pain medicine called suzetrigine for people who have a knee replacement. It aims to see if it helps control pain after surgery better or with fewer side effects than usual care.
New York, New YorkAges 18–80 - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT07777757Recruiting
Robotic knee surgery: does implant type affect alignment accuracy?
This study compares two types of knee implants used during robotic-assisted surgery to see which one gives more accurate alignment. It may help find the best implant for your new knee.
Hong Kong, Sandy BayAges 18 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07629388Recruiting
Nerve block for pain after knee replacement surgery
This trial tests whether adding a nerve block (a numbing injection near the nerve) to the usual pain plan can better control pain after a total knee replacement. The goal is to help you recover with less pain and fewer side effects.
DijonAges 18 years+ - NCT07598539Recruiting
Knee replacement recovery care at UPMC
This study compares different rehabilitation plans after knee replacement surgery to find the best way to help you recover. If you're having knee replacement at a UPMC hospital and plan to use UPMC for your rehab, this trial may be for you.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07577869Recruiting
Nerve blocks for pain relief after knee replacement
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
Kayseri, KocasinanAges 18–80 - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07551856Recruiting
Robotic vs. manual knee replacement surgery for arthritis
This study compares two ways to perform knee replacement surgery for osteoarthritis: traditional manual surgery versus robotic-assisted surgery. Both are standard approaches; the trial tests whether robotic guidance improves how well your knee works after surgery.
Glasgow, ScotlandAges 18 years+ - NCT07556003Recruiting
Physical Therapy After Knee Replacement Surgery
This study tests whether a physical therapy program helps improve walking ability and foot pressure patterns in women who have had knee replacement surgery or have knee problems. The goal is to see if structured rehabilitation helps you walk better and more comfortably.
SakakahAges 40–70 - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75 - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT07471243Recruiting
Dressing and wound care experiences after hip or knee replacement
This study looks at how people care for their surgical wounds and dressings after hip or knee replacement surgery. It aims to learn what helps patients feel more comfortable and confident in their recovery.
Bournemouth, DorsetAges 18 years+ - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT07437469Recruiting
Binaural beats for pain and anxiety after surgery
This trial tests if listening to binaural beats (a type of sound therapy) after hip or knee replacement surgery can help reduce pain and anxiety. You would receive the sound therapy through headphones while in the recovery room.
Miami, FloridaAges 18–99 - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+
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Common questions
- Are there clinical trials for total knee replacement?
- Yes. Clin2 currently lists 122 recruiting total knee replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.