Clinical trials
Arthroplasty, Replacement, Knee clinical trials
Below are recruiting arthroplasty, replacement, knee clinical trials, each written for real people, not researchers. We’re tracking 102 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06010979Recruiting
Knee replacement with digital help study
This study looks at knee replacement surgery done with digital tools like robots or computer guidance. It may help people with knee arthritis find better ways to have surgery and recover.
Beijing, Beijing MunicipalityAges Any age - NCT07864896RecruitingPhase 3
Study of a new pain medicine after knee replacement surgery
This trial tests a new oral pain medicine called suzetrigine for people who have a knee replacement. It aims to see if it helps control pain after surgery better or with fewer side effects than usual care.
New York, New YorkAges 18–80 - NCT07871487Recruiting
Brain protein changes after hip or knee replacement surgery
This study looks at whether having hip or knee replacement surgery with spinal anesthesia affects certain proteins in the brain that are linked to memory and thinking. It compares people having surgery with people who have arthritis but are not having surgery, to help understand if the surgery causes any short-term brain changes.
UppsalaAges 55–75 - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07577869Recruiting
Nerve blocks for pain relief after knee replacement
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
Kayseri, KocasinanAges 18–80 - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07551856Recruiting
Robotic vs. manual knee replacement surgery for arthritis
This study compares two ways to perform knee replacement surgery for osteoarthritis: traditional manual surgery versus robotic-assisted surgery. Both are standard approaches; the trial tests whether robotic guidance improves how well your knee works after surgery.
Glasgow, ScotlandAges 18 years+ - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75 - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT07465159Recruiting
Prehabilitation for frail patients before hip or knee replacement
This study tests whether a 'prehabilitation' program (tailored exercise and nutrition support before surgery) helps older patients who are frail recover better after hip or knee replacement. Participants will be randomly assigned to either the prehabilitation group or the usual care group.
ReykjavikAges 70 years+ - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT07437469Recruiting
Binaural beats for pain and anxiety after surgery
This trial tests if listening to binaural beats (a type of sound therapy) after hip or knee replacement surgery can help reduce pain and anxiety. You would receive the sound therapy through headphones while in the recovery room.
Miami, FloridaAges 18–99 - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT07362589Enrolling by invitation
Does pain education before knee or hip replacement help?
This study tests whether a special education session before knee or hip replacement surgery can help reduce anxiety, pain, and the need for pain medicine after surgery. If you are scheduled for joint replacement and can take part in a short learning session, you may be eligible.
Istanbul, KayişdağiAges 18 years+ - NCT07356323Recruiting
Study on antibacterial drape for hip or knee replacement
This trial tests if a special antibacterial drape reduces contamination during hip or knee replacement surgery. The drape is placed over the skin to help prevent infection.
Fishers, IndianaAges 22 years+ - NCT07360392Recruiting
Nerve block comparison for knee replacement pain
This study compares two numbing techniques (nerve blocks) for pain relief after knee replacement surgery. The goal is to find which one works better and helps you recover with less pain.
AmasyaAges 18–80 - NCT07337772Recruiting
Comparing corticosteroid doses in knee replacement pain relief injection
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Fuzhou, FujianAges 18–100 - NCT04884542Recruiting
Testing a knee replacement implant for total knee arthroplasty
This study looks at outcomes after surgery using the Multigen Plus H knee replacement system, sometimes with special add-on parts called AMF TT cones. It may help improve how well these knee implants work and how patients recover after total knee replacement.
GhentAges 18 years+
Hear when a new Arthroplasty, Replacement, Knee trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for arthroplasty, replacement, knee?
- Yes. Clin2 currently lists 102 recruiting arthroplasty, replacement, knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthroplasty, replacement, knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthroplasty, replacement, knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.