Clinical trials · Michigan
Knee Osteoarthritis clinical trials in Michigan
We’re tracking 12 recruiting knee osteoarthritis studies with a site in Michigan — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Michigan
- NCT04992624RecruitingPhase 2
Cannabinoid treatment effects on knee pain and nerve signals
This Phase 2 study tests whether a cannabinoid-related treatment changes how pain works in people with knee osteoarthritis. It uses questionnaires, MRI, and gentle nerve testing to understand if treatment helps pain and pain-related signals.
Ann Arbor, MichiganAges 21–75 - NCT06580561Recruiting
Exercise and insomnia treatment for knee pain
This study combines a gentle exercise program with a treatment for insomnia to see if it helps older adults with knee osteoarthritis feel less pain and sleep better. You will attend group exercise classes and receive sleep coaching.
Ann Arbor, MichiganAges 50 years+ - NCT06917404RecruitingPhase 3
Knee osteoarthritis pain study: comparing a new injection to placebo
This phase 3 study tests whether a medicine called pentosan polysulfate sodium (PPS), given as a shot under the skin, reduces pain in people with knee osteoarthritis. It compares PPS to a placebo (a shot with no active medicine) to see if it is safe and effective.
Farmington Hills, MichiganAges 18 years+ - NCT07580716RecruitingPhase 2
Knee Injection Treatment for Moderate Osteoarthritis
This study tests a new cell-based injection (Allocetra) directly into the knee joint for people with moderate osteoarthritis who haven't benefited from other treatments. The goal is to reduce pain and improve knee function.
Troy, MichiganAges 64 years+ - NCT04821154Recruiting
Testing outcomes after revision knee replacement with a Persona system
This study looks at how well a specific revision knee replacement system (the Persona system) works after earlier knee problems or surgeries. You may be eligible if you need a revision knee and can follow follow-up care instructions; the trial also checks for certain infection, bone, and health-safety factors.
Rochester, MichiganAges 18 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Rochester Hills, MichiganAges 45–80 - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Troy, MichiganAges 18 years+ - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Detroit, MichiganAges 18–80 - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Bay City, MichiganAges 40 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07673328Recruiting
Knee brace study for people with knee arthritis
This study tests a motorized knee brace for people with knee osteoarthritis. The brace helps support your knee as you walk, climb stairs, and go up and down ramps.
Ann Arbor, MichiganAges 18–85 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Bay City, MichiganAges 18 years+
Knee Osteoarthritis trials by city in Michigan
Where these studies are running in Michigan
Institutions with a site for the recruiting knee osteoarthritis studies listed above.
- University of Michigan · 4 studies
- Great Lakes Research Group · 2 studies
- Arcturus Healthcare, PLC
- Ascension Providence Rochester Hospital
- Henry Ford Health
- Henry Ford Medical Center - Grosse Pointe Cottage
- Insight Institute of Neurosurgery & Neuroscience
- Michigan Orthopaedic & Spine Surgeons
What taking part in a knee osteoarthritis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Knee Osteoarthritis trials in other states
Common questions
- Are there knee osteoarthritis clinical trials in Michigan?
- Yes. We're currently tracking 12 recruiting knee osteoarthritis studies with a site in Michigan, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a knee osteoarthritis study in Michigan?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Michigan to take part?
- Not necessarily. These studies have a site in Michigan, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New knee osteoarthritis studies open in Michigan regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.