Clinical trials
Knee Pain Arthritis clinical trials
Below are recruiting knee pain arthritis clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06632639Recruiting
Wedged insoles with ankle straps for knee pain and bow legs
This trial tests whether special shoe inserts (wedged insoles) combined with ankle straps can reduce pain and improve knee alignment in people with mild bow legs and inner knee pain. It aims to help those who have not had knee surgery and can walk without help.
GizaAges 20–60 - NCT07303998Recruiting
Brain stimulation and chair yoga for knee pain in Alzheimer's
This study tests two treatments together for people with Alzheimer's who also have chronic knee pain: a gentle brain stimulation (tDCS) and online chair yoga. The goal is to see if these can reduce knee pain and improve daily life.
Tucson, ArizonaAges 60 years+ - NCT06488144RecruitingPhase 3
Knee arthritis rehab: helping veterans keep improving
This study tests a program that helps veterans with knee osteoarthritis keep up the gains they make in physical therapy. It uses a Fitbit and a smartphone app to support you and track your activity after your PT sessions end.
Birmingham, AlabamaAges 40–90 - NCT04427709RecruitingPhase 2
Testing a brain-activity measure using oxytocin and eye movements
This study tests whether a particular brain-activity signal—seen in small rhythmic eye movements—can be measured reliably. It also looks at how oxytocin (a hormone used in medical settings) affects that signal.
Winston-Salem, North CarolinaAges 18–75 - NCT06600815Recruiting
Step-by-step numbing shots for pain relief in knee replacement
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
Fuzhou, FujianAges 18 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT06580561Recruiting
Exercise and insomnia treatment for knee pain
This study combines a gentle exercise program with a treatment for insomnia to see if it helps older adults with knee osteoarthritis feel less pain and sleep better. You will attend group exercise classes and receive sleep coaching.
Ann Arbor, MichiganAges 50 years+ - NCT06956222Recruiting
Home vs in-person rehab for knee osteoarthritis
This study compares doing physical therapy exercises at home through a video call (tele-rehab) versus doing them in person at a clinic. It is for people with mild to moderate knee osteoarthritis to see if home rehab works just as well.
JeddahAges 40–80 - NCT06684587Recruiting
Telehealth exercise and mindfulness for knee osteoarthritis pain
This study tests whether a telehealth program combining exercise and mindfulness can help reduce knee pain from osteoarthritis. It is designed for people who have had knee pain for at least 3 months and can attend sessions remotely.
Boston, MassachusettsAges 50 years+ - NCT06878417Recruiting
Cannabinoids for osteoarthritis knee or hip pain
This study tests if cannabinoid medications can reduce pain interference in daily life for people with hip or knee osteoarthritis. It may be a new option for moderate to severe pain.
Toronto, OntarioAges 40–80 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT07145645RecruitingPhase 3
Comparing topical diclofenac to oral ibuprofen for pain from ankle or knee injuries in children
This study compares a topical gel (diclofenac) applied directly to the injury site versus an oral medication (ibuprofen) taken by mouth to see which works better for treating pain from ankle or knee injuries in children. It may offer a way to relieve pain without a pill.
Calgary, AlbertaAges 6–18 - NCT06974474RecruitingPhase 4
Guselkumab for pain in psoriatic arthritis
This study tests if guselkumab can reduce pain and inflammation in people with psoriatic arthritis. You may join if standard treatments have not worked well enough or caused side effects.
Rome, ItalyAges 18–80
Hear when a new Knee Pain Arthritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for knee pain arthritis?
- Yes. Clin2 currently lists 86 recruiting knee pain arthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee pain arthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee pain arthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.