Clinical trials
Osteoarthritis Knee Pain clinical trials
Below are recruiting osteoarthritis knee pain clinical trials, each written for real people, not researchers. We’re tracking 283 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06228573Recruiting
Brain stimulation and yoga for knee pain
This study combines a gentle brain stimulation technique (tDCS) with yoga to see if it helps reduce knee pain and improve movement in people with knee osteoarthritis.
Hamilton, OntarioAges 45 years+ - NCT07308834RecruitingPhase 1/Phase 2
Knee injection study for moderate to severe osteoarthritis pain
This study tests a new knee injection called CX-011 to see if it can reduce pain and improve function in people with knee osteoarthritis. It may be a good option if you have tried other treatments without enough relief.
Los Angeles, CaliforniaAges 40–75 - NCT07785401Recruiting
Platelet-rich plasma plus hyaluronic acid for knee osteoarthritis
This study tests whether adding platelet-rich plasma (PRP) to hyaluronic acid injections improves knee osteoarthritis pain and function better than hyaluronic acid alone. You may be eligible if you have moderate knee osteoarthritis and no other knee problems.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07784907Recruiting
Platelet-rich plasma and hyaluronic acid for knee arthritis
This trial tests whether a combination of platelet-rich plasma (a concentrate from your own blood) and hyaluronic acid (a joint lubricant) helps reduce pain and improve function in people with knee arthritis. You may be eligible if you have moderate knee pain but your other knee is relatively pain-free.
Chełm, Lublin VoivodeshipAges 18 years+ - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT07639060Recruiting
Pain Relief Study Using Freezing Nerve Treatment
This study watches how well a freezing procedure works for chronic pain over 6 to 12 months. Your doctor thinks this procedure could help your pain, and the study simply tracks your recovery through questionnaires to help doctors understand if it works.
Old Saybrook, ConnecticutAges 18 years+ - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT07522489Recruiting
New knee replacement surgery guidance methods compared
This study compares two ways doctors use computer guidance during robotic knee replacement surgery for severe knee arthritis. The trial tests whether both methods work equally well or if one is better for patient recovery and results.
Warsaw, MazovianAges 18 years+ - NCT07664371Recruiting
Cold therapy versus heat therapy for knee arthritis pain
This study compares two minimally invasive treatments for knee pain caused by arthritis when other treatments haven't worked. One uses cold (cryoneurolysis) and the other uses heat (radiofrequency) to calm nerves and reduce pain.
TantaAges 18 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT07733518Recruiting
Exercise comparison for knee osteoarthritis
This trial compares two types of exercise—eccentric training and low-load blood flow restriction training—to see which is better for reducing pain and improving function in people with knee osteoarthritis.
Rawalpindi, Punjab ProvinceAges 40–70 - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Mobile, AlabamaAges 18 years+ - NCT06569836Recruiting
Study on digital program for chronic knee pain
This trial tests a digital program to help people manage chronic knee pain. If you are 55 or older and have had knee pain recently, this study may be a good fit.
Hong KongAges 55 years+ - NCT05020028RecruitingPhase 2/Phase 3
CBD to reduce knee pain from osteoarthritis
This study tests cannabidiol (CBD) to help lower pain from knee osteoarthritis. It may be an option if you have ongoing knee pain and meet age, safety, and medication guidelines.
New York, New YorkAges 40–75 - NCT07351968RecruitingPhase 1
Study of HRS-2129 for knee osteoarthritis pain
This trial tests an investigational drug, HRS-2129, for people with knee osteoarthritis who have moderate to severe pain. It aims to see if the drug is safe and effective at reducing pain.
Nanjing, JiangsuAges 18–80 - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT07731737Recruiting
Biofeedback vs foam roller for knee osteoarthritis
This trial compares two non-surgical therapies—pressure biofeedback and foam rolling—to see which better reduces pain, improves muscle function, and boosts quality of life in people with early-stage knee osteoarthritis.
LahoreAges 45–65 - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT03491761RecruitingPhase 2
PRP injection versus hyaluronic acid shots for knee arthritis
This trial tests whether a platelet-rich plasma (PRP) shot works better than a standard hyaluronic acid (“gel”) injection to reduce knee osteoarthritis pain. It may help people with ongoing knee pain choose the treatment that relieves symptoms more effectively.
Skokie, IllinoisAges 18–75 - NCT03711773Recruiting
Low-impact exercise classes for joint pain
This study tests a gentle, low-impact exercise program to improve pain and function for adults with knee, ankle, and/or hip pain. You’ll also attend dietitian and behavioral health classes as part of standard care while you participate.
Columbia, MissouriAges 18 years+ - NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT07703293Recruiting
Testing nerve branches for chronic knee pain relief
This study tests a procedure targeting specific nerve branches in the thigh to treat long-lasting knee pain from osteoarthritis. It may help people who haven't found relief from standard treatments like pain relievers or physical therapy.
AnkaraAges 45–80 - NCT07537153Recruiting
Blocking Blood Vessels to Reduce Knee Arthritis Pain
This trial tests a procedure called genicular artery embolization, which blocks small blood vessels around the knee to reduce pain from moderate arthritis. It may help people whose knee pain hasn't improved with medications.
Chicago, IllinoisAges 40–80 - NCT04814082Recruiting
Compare two knee implant types for walking and function
This study compares two designs of knee replacement implants to see how they affect walking, function, and outcomes after surgery. You may be randomly assigned to one of the implant types used for your specific, approved knee replacement.
Baltimore, MarylandAges 18–75
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Common questions
- Are there clinical trials for osteoarthritis knee pain?
- Yes. Clin2 currently lists 283 recruiting osteoarthritis knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.