Clinical trials
Malignancy clinical trials
Below are recruiting malignancy clinical trials, each written for real people, not researchers. We’re tracking 1,542 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06089083Recruiting
Helping gynecologic cancer patients with frailty recover function
This study tests a program to help gynecologic cancer patients who are frail improve their physical function and quality of life during treatment. It aims to see if extra support can help you stay stronger and recover better.
San Francisco, CaliforniaAges 18 years+ - NCT06089408Recruiting
Weighted blanket use to reduce anxiety in cancer patients
This trial tests whether using a weighted blanket can help lower anxiety in people who are about to start chemotherapy. Participants will use the blanket during treatment to see if it promotes calmness.
Columbus, OhioAges 18 years+ - NCT06101277Recruiting
Local therapy for limited new cancer growth in digestive cancers
This trial tests a cancer treatment that uses local therapies (like radiation or targeted heat) to destroy a small number of growing spots. It is for people with certain gastrointestinal cancers whose main treatment is working well except for a few new spots, so they can avoid switching to a different drug right away.
Sacramento, CaliforniaAges 18 years+ - NCT06103682Recruiting
Treating growing lung spots with local therapy
This trial tests if focusing treatment on a few new or growing lung tumors can help people with lung cancer who are already on systemic therapy. You may qualify if you have stable disease overall but a small number of new spots that can be safely treated with radiation or other local procedures.
Sacramento, CaliforniaAges 18 years+ - NCT06099743Recruiting
Support program for people with brain tumors
This study tests a support program that helps people with brain tumors cope with their diagnosis and treatment. The program uses acceptance and commitment therapy, which focuses on accepting difficult emotions and committing to actions that improve well-being.
Boston, MassachusettsAges 18 years+ - NCT05717153RecruitingEarly Phase 1
Test drugs through the tumor to study brain tumor metabolism
This early-phase study tests two drugs (DFMO and AMXT 1501) given directly into the tumor to see how they affect tumor biology and metabolism. Researchers may learn whether this approach could be safer and helpful for people with diffuse or high-grade glioma.
Rochester, MinnesotaAges 18 years+ - NCT03800693RecruitingPhase 2
Shorter vs longer oxaliplatin infusions for gut cancer
This Phase 2 study compares giving oxaliplatin by IV for 2 hours versus 6 hours, along with the standard FOLFOX6 chemotherapy. It aims to see if the shorter infusion works as well and is manageable for people with gastrointestinal cancers.
Atlanta, GeorgiaAges 18 years+ - NCT02280161Recruiting
Study of inherited cancer gene samples in blood and saliva
This study collects blood and saliva to look for inherited gene changes in people who have been diagnosed with cancer. It may help researchers understand what genetic risks could be involved, which could guide future cancer care.
Los Angeles, CaliforniaAges 18 years+ - NCT06066203RecruitingPhase 1/Phase 2
Study of GNC-035 for lymphoma that returned or didn't respond to treatment
This trial tests a new drug, GNC-035, for people with non-Hodgkin's lymphoma that has come back (relapsed) or stopped responding to standard treatments (refractory). The goal is to see if GNC-035 can help when other options haven't worked.
Beijing, Beijing MunicipalityAges 18–75 - NCT06060873Recruiting
Using a blood test to find active germ cell tumors
This trial tests whether a blood test called miRNA-371 can detect active germ cell tumors in patients who have had surgery or are being watched. It may help guide treatment decisions without needing extra biopsies or scans.
Birmingham, AlabamaAges 18 years+ - NCT06079970Recruiting
Testing a microscope during lung biopsy
This trial tests if a special microscope (confocal laser endomicroscopy) used during a bronchoscopy can help doctors see and diagnose suspicious lung spots more clearly. It may help you if you have a small-to-medium sized spot in your lung that needs a biopsy.
New York, New YorkAges 18 years+ - NCT06070376Recruiting
Comparing two stents for esophageal cancer swallowing problems
This study compares two types of stents (metal tubes) placed in the esophagus to help people with advanced esophageal cancer swallow more easily. Both stents are designed to keep the esophagus open and improve quality of life.
São Paulo, São PauloAges 18 years+ - NCT06071507Recruiting
Comparing treatments for stomach blockage in pancreatic cancer
This trial compares three ways to relieve a stomach or duodenal blockage caused by pancreatic cancer: placing a stent, performing a bypass with a thin tube (endoscopy), or surgical bypass. It aims to find which option helps patients eat and feel better sooner.
ParisAges 18 years+ - NCT06041516RecruitingPhase 1
New drug ADCT-701 for neuroendocrine and nerve tumors
This trial tests a new drug called ADCT-701 for people with certain rare cancers (neuroendocrine tumors, adrenal cancer, or a type of nerve tumor) that have come back or spread. The drug is an antibody-drug conjugate, which works like a targeted missile to kill cancer cells while trying to spare healthy ones.
Bethesda, MarylandAges 18–120 - NCT06043011Recruiting
Registry for non-Hodgkin lymphoma patients on systemic therapy
This registry tracks people with non-Hodgkin lymphoma who are starting a new line of systemic therapy. It collects information to better understand how treatments work in real life, and optionally asks you to fill out surveys about your symptoms and quality of life.
Freiburg im BreisgauAges 18 years+ - NCT06051695RecruitingPhase 1/Phase 2
CAR T cell therapy for mesothelin-positive solid tumors
This trial tests a new type of immune cell therapy (CAR T-cells) designed to target cancer cells that have a protein called mesothelin but have lost a marker that lets them hide from the immune system. It's for people with advanced solid tumors who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT06053333Recruiting
Social factors in liver, bile duct, and gallbladder cancer
This study looks at how social and economic factors (like income, housing, and support) affect people with liver, bile duct, or gallbladder cancer. The goal is to learn more about these factors to improve care and outcomes.
Rochester, MinnesotaAges 18 years+ - NCT06047886RecruitingPhase 1
Study of a new way to select stem cells for transplant
This trial tests a machine that picks out healthy stem cells for a bone marrow transplant. It may help people with certain blood cancers or disorders get a transplant with fewer complications.
Birmingham, AlabamaAges 4 weeks–75 years - NCT06040970RecruitingPhase 1/Phase 2
Sacituzumab govitecan plus cisplatin for recurrent ovarian/endometrial cancer
This trial tests a combination of two drugs—sacituzumab govitecan and cisplatin—for women with ovarian or endometrial cancer that has come back after responding to platinum chemotherapy. The goal is to see if the combination works better than current options.
New York, New YorkAges 18 years+ - NCT06043713RecruitingPhase 1
T-cell therapy for KRAS G12V solid tumors
This trial tests a personalized T-cell therapy designed to recognize and attack cancer cells with a specific KRAS G12V mutation. It is for people with metastatic solid tumors that have this mutation and a specific immune type (HLA-A*11:01).
Seattle, WashingtonAges 18 years+ - NCT06016855RecruitingPhase 4
Surgery before radiation therapy for neuroendocrine tumors
This trial tests if removing as much tumor as possible through surgery before a targeted radiation therapy (PRRT) can help people with well-differentiated neuroendocrine tumors that have spread to the liver. The goal is to see if this approach works better than radiation therapy alone.
Nashville, TennesseeAges 18 years+ - NCT06022965Recruiting
Telemedicine support for older adults with cancer
This study uses telemedicine (video or phone visits) to help older adults with cancer, especially those in underserved communities, get better care. If you're 65 or older and starting a new cancer treatment, you may be able to join from home in English, Spanish, or Chinese.
Duarte, CaliforniaAges 65 years+ - NCT06028828RecruitingPhase 2
Adapted conditioning for stem cell transplant
This trial tests a risk-adapted conditioning regimen (chemotherapy and/or radiation given before transplant) for people with certain blood cancers or bone marrow disorders who need a stem cell transplant from a donor. The goal is to tailor the conditioning strength to each patient’s risk, which may help improve outcomes and reduce side effects.
Orange, CaliforniaAges 18–70 - NCT06001788RecruitingPhase 1
Ziftomenib for relapsed or refractory acute myeloid leukemia
This trial tests a new drug combination called ziftomenib for people whose acute myeloid leukemia (AML) has come back or hasn't responded to treatment. Researchers will check how safe it is and what side effects happen.
Gilbert, ArizonaAges 18 years+
Hear when a new Malignancy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for malignancy?
- Yes. Clin2 currently lists 1,542 recruiting malignancy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malignancy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malignancy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.