Clinical trials
Manipulation clinical trials
Below are recruiting manipulation clinical trials, each written for real people, not researchers. We’re tracking 91 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07322185Enrolling by invitation
Comparing two bodywork methods for piriformis syndrome
This study compares two hands-on treatments, Stecco-fascial manipulation and Rolfing, for people with piriformis syndrome—a condition that causes buttock pain. The goal is to see which approach works better for reducing pain and improving movement.
Sambrial, Punjab ProvinceAges 25–45 - NCT07258537Enrolling by invitation
Comparing two hand therapies for sacroiliac joint pain
This study compares two types of hands-on therapy (a gentle side-lying adjustment vs. a lower back roll) to see which works better for long-lasting low back pain caused by the sacroiliac joint. If you have ongoing pain and are open to physical treatments, this trial may help find the best approach.
Gujrat, Punjab ProvinceAges Any age - NCT07216300Enrolling by invitation
Osteopathic treatment for baseball pitchers
This trial tests if osteopathic manipulation of the shoulder and hip can improve pitching performance in college baseball players. It may help you throw better and prevent injuries.
Hattiesburg, MississippiAges 18–102 - NCT07161661Recruiting
Osteopathic treatment for chronic low back pain in veterans
This trial tests whether adding osteopathic manipulative treatment (OMT) to standard VA care helps reduce chronic low back pain. OMT involves a healthcare provider using their hands to move and stretch muscles and joints.
Hines, IllinoisAges 18 years+ - NCT06502951Recruiting
Treatment for headache and neck pain after whiplash
This study tests if combining spinal manipulation and dry needling can reduce headache and neck pain in people who have had whiplash from a car accident. It may help if you've had symptoms for more than 4 weeks.
Montgomery, AlabamaAges 18–65 - NCT06971159Recruiting
Vibration therapy and osteopathic care for obesity
This study tests whether gentle whole-body vibration therapy and osteopathic manual treatment (hands-on adjustments) can help people with obesity. It aims to see if these treatments improve weight-related health and well-being.
Rio de Janeiro, Rio de JaneiroAges 18–65 - NCT06992375Recruiting
Shoulder manipulation study for volleyball players
This trial tests a shoulder manipulation technique in healthy volleyball players to see if it improves shoulder function and performance. It may help if you play regularly and haven't had recent injuries or surgeries.
GdanskAges 18–30 - NCT07025434Recruiting
Hip Bump Manipulation vs Sham in Healthy Adults
This study tests a hip adjustment technique (called hip bump manipulation) to see how it affects joint movement and muscles in healthy adults. If you join, you will receive either the real manipulation or a fake (sham) treatment, so researchers can compare the two.
Orangeburg, New YorkAges 18–45 - NCT06986122Recruiting
Testing virtual reality to help with pain
This study tests whether virtual reality can help change how you feel pain. You'll be asked to complete tasks and rate your experience.
Hanover, New HampshireAges 18–55 - NCT06671600Recruiting
Osteopathic treatment for sleep in Parkinson's disease
This study tests if gentle hands-on treatments (osteopathic manipulative medicine) can improve sleep quality for people with Parkinson's disease. You will wear a Fitbit and a ring to track your sleep, and receive the treatments over several sessions.
Old Westbury, New YorkAges Any age - NCT06386029Recruiting
Bedtime routine study for children with autism
This study tests a new bedtime routine designed to help children with autism who are very sensitive to sensory input and have trouble settling down at night. It may help your child fall asleep more easily.
Pittsburgh, PennsylvaniaAges 6–10 - NCT06158880Recruiting
Alcohol and men's sexual risk behaviors
This study looks at how alcohol affects men's decisions about sex, especially risky behaviors like not using condoms. If you join, you may help researchers understand how to reduce HIV and STI risk.
Phoenix, ArizonaAges 21–30 - NCT06072599Enrolling by invitation
Osteopathic treatment for non-muscle and joint conditions
This trial looks at how osteopathic manipulative treatment can help with health issues that are not related to muscles or joints, like problems with digestion, breathing, or circulation. It aims to see if this type of hands-on care can improve your overall well-being.
Kirksville, MissouriAges 18 years+ - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT04240561Recruiting
Study of hearing aid results in people with Alzheimer’s dementia
This study looks at how much hearing aid outcomes vary in older adults who have Alzheimer’s dementia or mild memory problems. It may help researchers understand what hearing aids work best and for whom.
Chicago, IllinoisAges 50–90 - NCT07216534Recruiting
Virtual reality streetscape study for psychosocial response
This study uses virtual reality to show different versions of your neighborhood to see how it affects your feelings and well-being. You will attend a two-hour visit at Ohio State University.
Columbus, OhioAges 18 years+ - NCT02257723Recruiting
Testing combined Korean herbal and therapy for hospitalized spine or joint pain
This trial studies whether a combined complementary treatment approach helps people who are hospitalized for spine or joint problems. It may help reduce the types of pain that come from those areas.
Seoul, Gangnam-GuAges Any age - NCT07870044Recruiting
Virtual reality to boost body awareness
This study uses virtual reality to help people feel more connected to their body. It may benefit healthy people or those with spinal cord injury or stroke.
Bosisio Parini, LeccoAges 12–50 - NCT07849140Recruiting
Hands-on therapy for painful periods
This study tests whether osteopathic manipulative treatment (a hands-on approach to relieve tension and improve blood flow) can reduce the pain and other symptoms of painful periods. It is only for people at Western University of Health Sciences.
Pomona, CaliforniaAges 20–51 - NCT07725198Recruiting
Neck muscle responses after upper neck therapy
This trial looks at how a specific neck therapy affects a small muscle at the top of your neck. It may help researchers understand how hands-on treatment works for neck pain or stiffness.
Fort Myers, FloridaAges 18–65 - NCT07518732Enrolling by invitation
Thoracic Spine Treatment: Massage and Manipulation Study
This study tests whether hands-on treatments—spinal manipulation and massage—can reduce back pain, improve flexibility, and help with sleep in older adults with long-standing mid-back problems. You would receive these treatments over time and answer questions about your pain and sleep.
IstanbulAges 18–65 - NCT06766279Recruiting
OMT for smell loss after COVID-19
This trial tests if osteopathic manipulative treatment (OMT) can help people regain their sense of smell after COVID-19. OMT is a hands-on therapy used by osteopathic doctors to improve body function.
Las Cruces, New MexicoAges 18 years+ - NCT07476937Recruiting
Understanding Sleep and Emotions in Children with Autism
This study looks at how sleep, emotions, and arousal differ in children with autism who have bedtime struggles. If your child is 6 to 10 years old and has trouble falling asleep, this trial may help researchers understand and improve sleep for kids like yours.
Pittsburgh, PennsylvaniaAges 6–10 - NCT07438912Recruiting
Mind After Midnight: A study on late-night thinking and suicide risk
This study looks at how thinking changes late at night in people who have had suicidal thoughts in the past 6 months. The goal is to understand risk and find better ways to help.
Tucson, ArizonaAges 18–55
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Common questions
- Are there clinical trials for manipulation?
- Yes. Clin2 currently lists 91 recruiting manipulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a manipulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a manipulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.