Clinical trials
Manipulation clinical trials
Below are recruiting manipulation clinical trials, each written for real people, not researchers. We’re tracking 94 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06971159Recruiting
Vibration therapy and osteopathic care for obesity
This study tests whether gentle whole-body vibration therapy and osteopathic manual treatment (hands-on adjustments) can help people with obesity. It aims to see if these treatments improve weight-related health and well-being.
Rio de Janeiro, Rio de JaneiroAges 18–65 - NCT06986122Recruiting
Testing virtual reality to help with pain
This study tests whether virtual reality can help change how you feel pain. You'll be asked to complete tasks and rate your experience.
Hanover, New HampshireAges 18–55 - NCT07025434Recruiting
Hip Bump Manipulation vs Sham in Healthy Adults
This study tests a hip adjustment technique (called hip bump manipulation) to see how it affects joint movement and muscles in healthy adults. If you join, you will receive either the real manipulation or a fake (sham) treatment, so researchers can compare the two.
Orangeburg, New YorkAges 18–45 - NCT07161661Recruiting
Osteopathic treatment for chronic low back pain in veterans
This trial tests whether adding osteopathic manipulative treatment (OMT) to standard VA care helps reduce chronic low back pain. OMT involves a healthcare provider using their hands to move and stretch muscles and joints.
Hines, IllinoisAges 18 years+ - NCT01765777Recruiting
Osteopathic hands-on therapy and light treatment for long-term low back pain
This trial studies whether hands-on osteopathic treatment and a type of light (phototherapy) can reduce chronic low back pain. It may help people who have had non-specific low back pain for at least 3 months.
Old Westbury, New YorkAges 18–65 - NCT07431788Recruiting
Uterine manipulator and sexual function after hysterectomy
This study tests whether using a uterine manipulator during abdominal hysterectomy affects sexual function after surgery. It may help women having hysterectomy for non-cancer reasons.
Istanbul, IstanbulAges 18 years+ - NCT07432750Recruiting
Osteopathic manipulation vs. wrist brace for carpal tunnel
This study tests whether osteopathic manipulation (a gentle hands-on treatment) works better than wearing a wrist brace for people with mild to moderate carpal tunnel syndrome. If you have mild or moderate carpal tunnel and haven't had surgery, this trial might help find a non-surgical option.
Old Westbury, New YorkAges 18 years+ - NCT06671600Recruiting
Osteopathic treatment for sleep in Parkinson's disease
This study tests if gentle hands-on treatments (osteopathic manipulative medicine) can improve sleep quality for people with Parkinson's disease. You will wear a Fitbit and a ring to track your sleep, and receive the treatments over several sessions.
Old Westbury, New YorkAges Any age - NCT07504640Recruiting
Spinal manipulation for heart health in children with cerebral palsy
This study tests whether a gentle spinal adjustment can improve how the heart adapts to stress in children with cerebral palsy. It may help your child's body handle daily challenges better.
LvivAges 4–18 - NCT07507604Recruiting
Spinal Adjustment and Pain Relief in Chronic Low Back Pain
This study tests whether a brief hands-on spinal adjustment can affect pain and inflammation markers in people with long-term low back pain. It aims to see if psychological factors like expectations influence how well the treatment works.
Biała Podlaska, Lublin VoivodeshipAges 18–65 - NCT07555873Recruiting
Osteopathic treatment versus physical therapy for neck and head dysfunction
This study compares two hands-on treatment approaches—osteopathic manipulation and physiotherapy—for chronic neck pain, headaches, and dizziness caused by cervical dysfunction. If you qualify, you'll receive one of these treatments and help researchers understand which works better.
Pristina, PejtonAges 18–65 - NCT07322185Enrolling by invitation
Comparing two bodywork methods for piriformis syndrome
This study compares two hands-on treatments, Stecco-fascial manipulation and Rolfing, for people with piriformis syndrome—a condition that causes buttock pain. The goal is to see which approach works better for reducing pain and improving movement.
Sambrial, Punjab ProvinceAges 25–45 - NCT06455423Enrolling by invitation
ELDOA and adjustments for upper back pain and posture
This study tests whether adding a gentle stretching technique (ELDOA) to standard upper back adjustments can improve upper back pain, reduce hunching, and correct forward head posture. It is for adults with upper back discomfort and postural issues.
Islamabad, FederalAges 19–44 - NCT06451783Enrolling by invitationEarly Phase 1
Herbal Medicine and Joint Manipulation for Knee Osteoarthritis
This trial tests a combination of a Chinese herbal formula (Shengyu Decoction) and a hands-on joint manipulation technique (Lijin Manipulation) to improve knee movement and reduce pain in people with knee osteoarthritis. It uses special 3D walking analysis to see how well the treatment works.
ShanghaiAges 45–85 - NCT06072599Enrolling by invitation
Osteopathic treatment for non-muscle and joint conditions
This trial looks at how osteopathic manipulative treatment can help with health issues that are not related to muscles or joints, like problems with digestion, breathing, or circulation. It aims to see if this type of hands-on care can improve your overall well-being.
Kirksville, MissouriAges 18 years+ - NCT06495021Recruiting
Osteopathic manipulation for newly diagnosed respiratory illness in older adults
This study tests whether osteopathic manipulation (a gentle hands-on treatment) helps older adults recover from common respiratory illnesses like bronchitis or pneumonia when added to regular care. It may be a good option for you if you're 65 or older and have just been diagnosed with a respiratory infection.
Bloomsburg, PennsylvaniaAges 65–100 - NCT06377917Recruiting
Testing timing of assisted hatching in IVF
This study compares two different timings for a lab procedure called assisted hatching (making a small opening in the embryo's outer shell) to see if one helps more embryos implant. You may be eligible if you're doing IVF with a frozen embryo transfer of a single screened embryo.
Marlton, New JerseyAges 18–42 - NCT06996652RecruitingPhase 2
Study of adalimumab to delay Parkinson's symptoms in sleep disorder
This trial tests whether adalimumab, an immune system drug, helps people with REM sleep behavior disorder (a condition that may warn of Parkinson's disease) stay healthy longer. Participants will receive injections of the drug or a placebo to see if it prevents Parkinson's-related brain problems.
Los Angeles, CaliforniaAges 50–80 - NCT07390084Recruiting
How stress and social settings affect drinking decisions
This study looks at how stress and being with others might affect your decision to drink more alcohol. It helps researchers understand what influences drinking in social situations.
Seattle, WashingtonAges 21–50 - NCT06072378Recruiting
Decision-making and memory study with brain recordings
This study looks at how the brain makes decisions and forms memories. It uses brain recordings from patients already having surgery for epilepsy to understand these processes.
New Brunswick, New JerseyAges 18–65 - NCT06015607Recruiting
Testing a new tool for colon polyp removal
This trial tests a new device to help doctors remove larger, non-cancerous polyps from the colon during a colonoscopy. It may make the procedure easier and more effective for eligible patients.
Cleveland, OhioAges 21 years+ - NCT06821178Recruiting
My life and my experiences study for teens
This study looks at the life experiences of teenagers ages 12 to 18, comparing those who have had contact with social services or dependency court with those who have always lived with a parent. It helps researchers understand how different backgrounds affect well-being.
Irvine, CaliforniaAges 12–18 - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT06448351Recruiting
Changing nicotine in e-cigarettes to reduce harm
This study tests how changing the amount of nicotine in e-cigarettes affects people's behavior. It looks at two groups: young adults who already vape and older adult smokers who want to try vaping, to see if different nicotine levels can help reduce smoking or make vaping safer.
Columbus, OhioAges 21–65
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Common questions
- Are there clinical trials for manipulation?
- Yes. Clin2 currently lists 94 recruiting manipulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a manipulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a manipulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.