Clinical trials
Manipulation clinical trials
Below are recruiting manipulation clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06872918Recruiting
Study of a back manipulation for lumbar disc herniation
This study tests a specific type of back manipulation (Lever Positioning Manipulation) to understand how it affects the discs in the lower spine. It may help people with a herniated disc at L4-L5 find a non-surgical treatment option.
Hangzhou, ZhejiangAges 20–60 - NCT07498140Recruiting
Epidural steroid injection for leg and back pain
This study is testing a treatment that involves an injection to reduce nerve-related leg and back pain. It looks at how much information about the procedure affects a patient's outlook and pain relief.
Chicago, IllinoisAges Any age - NCT07641621Recruiting
Chiropractic Ankle Treatment and Jump Performance Study
This study tests whether chiropractic ankle manipulation improves how high and powerfully you can jump. Researchers will work with recreationally active adults to see if this treatment affects athletic performance.
Seneca Falls, New YorkAges 18–35 - NCT06849076Recruiting
Ankle joint motion and body awareness after stroke
This study tests if a hands-on ankle treatment can improve your sense of where your ankle is in space (proprioception) after a stroke. It looks at how well you can feel and control your ankle movement.
Bolu, MerkezAges 45–75 - NCT05687084Recruiting
Uterine manipulator vs no manipulator in endometrial cancer surgery
This trial compares using a surgical “uterine manipulator” device versus not using it during endometrial cancer surgery. It may help clarify which approach is safer and works better during planned hysterectomy.
Cuneo, ItalyAges 18–100 - NCT05986370Recruiting
Study on back pain and spinal manipulation
This trial tests whether spinal manipulation therapy (a type of hands-on treatment) can help people with long-term low back pain. It also compares their results to healthy volunteers of the same age and sex.
Trois-Rivières, QuebecAges 18–60 - NCT06307886Recruiting
Uterine manipulator in endometrial cancer surgery
This trial compares survival rates for patients with early-stage endometrial cancer who have laparoscopic hysterectomy with or without a uterine manipulator (a tool used during surgery).
IstanbulAges 18–75 - NCT06723353Recruiting
Combined therapy for belly separation in new mothers
This trial tests if a gentle hands-on treatment (visceral manipulation) plus special tape (kinesio taping) can help close the gap in your belly muscles, reduce pain, stop bladder leaks, and improve your pelvic floor strength and overall well-being after childbirth.
Karachi, SindhAges 35–45 - NCT06883513Recruiting
Osteopathic therapy for long COVID symptoms
This trial tests if gentle hands-on treatment (osteopathic manipulative therapy) can help relieve long-lasting COVID symptoms like fatigue, brain fog, and body pain.
Louisville, KentuckyAges 18 years+ - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT07633496Enrolling by invitation
Osteopathic hand therapy for healthy tears
This study tests whether gentle hands-on therapy (osteopathic manipulation) can change the makeup of your tears in a healthy way. It may help people who are interested in natural ways to support eye health.
Erie, PennsylvaniaAges 18 years+ - NCT06386029Recruiting
Bedtime routine study for children with autism
This study tests a new bedtime routine designed to help children with autism who are very sensitive to sensory input and have trouble settling down at night. It may help your child fall asleep more easily.
Pittsburgh, PennsylvaniaAges 6–10 - NCT06992375Recruiting
Shoulder manipulation study for volleyball players
This trial tests a shoulder manipulation technique in healthy volleyball players to see if it improves shoulder function and performance. It may help if you play regularly and haven't had recent injuries or surgeries.
GdanskAges 18–30 - NCT06158880Recruiting
Alcohol and men's sexual risk behaviors
This study looks at how alcohol affects men's decisions about sex, especially risky behaviors like not using condoms. If you join, you may help researchers understand how to reduce HIV and STI risk.
Phoenix, ArizonaAges 21–30 - NCT06510101Enrolling by invitation
Salvaging donor kidneys with stones
This study tests a way to remove kidney stones from donated kidneys before transplant, using a flexible scope to break up the stones. It might help people who receive a kidney that has stones.
Shenzhen, GuangdongAges 18–65 - NCT07258537Enrolling by invitation
Comparing two hand therapies for sacroiliac joint pain
This study compares two types of hands-on therapy (a gentle side-lying adjustment vs. a lower back roll) to see which works better for long-lasting low back pain caused by the sacroiliac joint. If you have ongoing pain and are open to physical treatments, this trial may help find the best approach.
Gujrat, Punjab ProvinceAges Any age - NCT07216300Enrolling by invitation
Osteopathic treatment for baseball pitchers
This trial tests if osteopathic manipulation of the shoulder and hip can improve pitching performance in college baseball players. It may help you throw better and prevent injuries.
Hattiesburg, MississippiAges 18–102 - NCT07723014Recruiting
Fascial vs muscle techniques for sacroiliac joint pain
This study compares two hands-on treatments for sacroiliac joint dysfunction, a common cause of lower back and hip pain. It aims to see which approach better reduces pain, improves movement, and helps with daily activities.
Lahore, Punjab ProvinceAges 30–45 - NCT04240561Recruiting
Study of hearing aid results in people with Alzheimer’s dementia
This study looks at how much hearing aid outcomes vary in older adults who have Alzheimer’s dementia or mild memory problems. It may help researchers understand what hearing aids work best and for whom.
Chicago, IllinoisAges 50–90 - NCT06502951Recruiting
Treatment for headache and neck pain after whiplash
This study tests if combining spinal manipulation and dry needling can reduce headache and neck pain in people who have had whiplash from a car accident. It may help if you've had symptoms for more than 4 weeks.
Montgomery, AlabamaAges 18–65 - NCT06830148Recruiting
Tongue movement after tongue-tie release for better breastfeeding
This study tests whether gently moving the tongue after a tongue-tie release (frenotomy) helps babies breastfeed better. It's for babies under 3 months old who are having their tongue-tie cut with scissors and are breastfeeding at least some of the time.
Washington D.C., District of ColumbiaAges Up to 3 months - NCT06837025Recruiting
Fascial manipulation for kids with cerebral palsy
This trial tests a hands-on technique called fascial manipulation to see if it improves movement and walking in children with cerebral palsy. It is for families living near Helsinki.
HelsinkiAges 7–14 - NCT06851234Recruiting
Osteopathic treatment for head injuries in MMA fighters
This trial tests if osteopathic manipulative treatment (a gentle hands-on therapy) helps mixed martial artists recover from head injuries. Part 1 studies how head injuries happen during fights; Part 2 offers the treatment to fighters who get a head injury.
Greenvale, New YorkAges 18–50 - NCT06971159Recruiting
Vibration therapy and osteopathic care for obesity
This study tests whether gentle whole-body vibration therapy and osteopathic manual treatment (hands-on adjustments) can help people with obesity. It aims to see if these treatments improve weight-related health and well-being.
Rio de Janeiro, Rio de JaneiroAges 18–65
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Common questions
- Are there clinical trials for manipulation?
- Yes. Clin2 currently lists 93 recruiting manipulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a manipulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a manipulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.