Clinical trials
Manipulation clinical trials
Below are recruiting manipulation clinical trials, each written for real people, not researchers. We’re tracking 94 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07193212Recruiting
Osteopathic treatment for low back pain and leg health
This study tests whether a hands-on osteopathic treatment can improve how your legs and feet work if you have chronic low back pain. It may help you understand if this type of manual therapy is a good option for your pain.
Auburn, AlabamaAges 18–65 - NCT06275308Recruiting
Testing carbon dioxide levels on eye structure in children
This study looks at how changing the level of carbon dioxide in the blood affects a layer in the back of the eye (the choroid) in children having an eye exam under anesthesia. It may help doctors understand eye health better.
Pittsburgh, PennsylvaniaAges Up to 8 years - NCT07725198Recruiting
Neck muscle responses after upper neck therapy
This trial looks at how a specific neck therapy affects a small muscle at the top of your neck. It may help researchers understand how hands-on treatment works for neck pain or stiffness.
Fort Myers, FloridaAges 18–65 - NCT07476937Recruiting
Understanding Sleep and Emotions in Children with Autism
This study looks at how sleep, emotions, and arousal differ in children with autism who have bedtime struggles. If your child is 6 to 10 years old and has trouble falling asleep, this trial may help researchers understand and improve sleep for kids like yours.
Pittsburgh, PennsylvaniaAges 6–10 - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT04570553Recruiting
Testing a tool during surgery for early endometrial cancer
This study looks at how well a surgical tool is used during standard surgery for early endometrial cancer, and whether it relates to test results from fluid taken in the abdomen. It may help surgeons improve how samples are collected and interpreted during routine care.
York, PennsylvaniaAges 18 years+ - NCT04586959Recruiting
Uterine movement study during minimally invasive cancer surgery
This study looks at how moving the uterus during minimally invasive surgery may affect women with early-stage endometrial cancer. It may help doctors choose the safest, most effective surgical approach.
Cleveland, OhioAges 18–90 - NCT04609709Recruiting
Physical therapy plus electrical dry needling for tension headaches
This trial tests whether specific physical therapy treatments—exercise, manual soft-tissue work, mobilization, and electrical dry needling/TENS—can reduce tension-type headaches. It may help if your headaches happen often and fit the trial’s “frequent” or “chronic” pattern.
Fort Wayne, IndianaAges 18–65 - NCT04788524Recruiting
Brain and stress study in depressed teens with control feelings
This study uses brain scans and short real-life mood/stress check-ins to understand how stress and perceived control work in teens with depression. It may help researchers better pinpoint brain patterns linked to depression and how teens experience control during stressful moments.
Belmont, MassachusettsAges 14–18 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45 - NCT05617365RecruitingPhase 1/Phase 2
Study treatment for chronic neck-related head and neck pain
This early-stage study tests a new treatment for people (women) who have long-lasting headaches and pain coming from the neck. It may help reduce symptoms, but you must match specific safety and diagnosis requirements.
East Lansing, MichiganAges 18–65 - NCT05848895Recruiting
Osteopathy treatment for infants with positional head shape
This study tests an osteopathic manual therapy plan (hands-on treatment) for babies with positional plagiocephaly, aiming to improve head shape and comfort. It also asks families to attend multiple treatment and measurement visits so researchers can track change over time.
San Diego, CaliforniaAges 1 day–4 months - NCT05884944Recruiting
Osteopathic massage study for leg muscle in Parkinson’s disease
This trial studies whether osteopathic manipulative medicine (gentle hands-on treatment) can change how leg muscles work in people with Parkinson’s disease. It may help with leg pain, cramping, or walking problems caused by Parkinson’s.
Old Westbury, New YorkAges 18 years+ - NCT06040957Recruiting
Bone marrow vs fat cells for knee osteoarthritis treatment
This trial compares using cells from your bone marrow or belly fat to treat knee osteoarthritis, aiming to reduce pain and improve function. It's for people who haven't gotten better with standard treatments like physical therapy or medications.
BolognaAges 40–75 - NCT06041282Recruiting
Comparing treatments for early frozen shoulder
This study compares two ways to treat early frozen shoulder (also called adhesive capsulitis): manual release by a therapist versus a home exercise program. It is for people who have had symptoms for 3 months or less and have not had shoulder surgery before.
Hangzhou, ZhejiangAges 40–80 - NCT06312696Recruiting
Neck movement study with spinal manipulation therapy
This study tests whether a special hands-on therapy (spinal manipulation) can help people with long-term neck pain. It will measure how the neck moves and whether the treatment improves movement and reduces pain.
Minneapolis, MinnesotaAges 18–39 - NCT06349590RecruitingPhase 1/Phase 2
Diet before colon cancer surgery to reduce recurrence
This trial tests whether a specific diet before colon cancer surgery can change the bacteria in your gut to help prevent the cancer from coming back or spreading. Patients who are eligible will follow the diet for a short time before their operation.
Chicago, IllinoisAges 18 years+ - NCT06376513Recruiting
Learning to use a penile implant pump
This study checks how well patients and their partners can use the pump part of a penile prosthesis (an implant for erectile dysfunction). It may help improve training for future patients.
Pierre-BéniteAges 18 years+ - NCT06454344Recruiting
Sleep and childhood experiences study in young adults
This study looks at how sleep is affected by tough childhood experiences. It tests whether changing sleep patterns can help young adults who have had these experiences and currently have poor sleep.
Iowa City, IowaAges 18–29 - NCT06465979Recruiting
How do people with hearing loss understand speech in different settings?
This study looks at how people with healthy hearing or hearing loss understand speech in different listening environments. You might join if you have normal hearing, mild hearing loss, or use a cochlear implant, and are a competent adult English speaker.
Minneapolis, MinnesotaAges 18–65 - NCT06471426Recruiting
Osteopathic treatment for neck pain and headaches
This study tests whether a type of hands-on treatment called osteopathic manipulation can help relieve neck pain and headaches. It's for people who have had these symptoms for more than a month.
Auburn, AlabamaAges 19–65 - NCT06492109Recruiting
Blood study on sleep loss
This study looks at blood samples to understand how sleep loss affects the body. It may help find new ways to diagnose or treat sleep problems.
Hangzhou, ZhejiangAges 18–80 - NCT06516575Recruiting
Listening effort in cochlear implant users
This study measures how much effort it takes to listen and understand speech for adults with cochlear implants compared to those with normal hearing. It can help researchers learn how to improve hearing outcomes.
Minneapolis, MinnesotaAges 18–75 - NCT06533345Recruiting
Pain-free research for chronic pain
This trial studies a collaborative approach to help people with chronic pain, which is pain that lasts beyond a recent injury. It may be a good fit if you're not currently seeking medication for your pain.
Auburn, AlabamaAges 21–80
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Common questions
- Are there clinical trials for manipulation?
- Yes. Clin2 currently lists 94 recruiting manipulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a manipulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a manipulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.