Clinical trials
Manipulation clinical trials
Below are recruiting manipulation clinical trials, each written for real people, not researchers. We’re tracking 91 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07390084Recruiting
How stress and social settings affect drinking decisions
This study looks at how stress and being with others might affect your decision to drink more alcohol. It helps researchers understand what influences drinking in social situations.
Seattle, WashingtonAges 21–50 - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT06894082Recruiting
Checking scan readings for solid cancer patients
This trial is checking how well radiologists (the doctors who read your scans) can measure tumors in patients with solid cancers. You will have your regular cancer scans, and the researchers will see if the scan-reading process runs smoothly. It's a study to improve how scan results are used in cancer care.
Marseille, Institut Paoli CalmettesAges 18 years+ - NCT04570553Recruiting
Testing a tool during surgery for early endometrial cancer
This study looks at how well a surgical tool is used during standard surgery for early endometrial cancer, and whether it relates to test results from fluid taken in the abdomen. It may help surgeons improve how samples are collected and interpreted during routine care.
York, PennsylvaniaAges 18 years+ - NCT07193212Recruiting
Osteopathic treatment for low back pain and leg health
This study tests whether a hands-on osteopathic treatment can improve how your legs and feet work if you have chronic low back pain. It may help you understand if this type of manual therapy is a good option for your pain.
Auburn, AlabamaAges 18–65 - NCT07179406Recruiting
Spinal cord stimulators for restless leg syndrome
This study tests whether a spinal cord stimulator can help people with restless leg syndrome (RLS). It compares people with RLS to healthy volunteers to see if the device reduces symptoms.
Birmingham, AlabamaAges 18 years+ - NCT07137273Recruiting
Study of rewards for problem behavior
This study looks at how different rewards (reinforcements) work best for people with neurodevelopmental conditions who exhibit problem behaviors. The goal is to find ways to improve behavior support.
Auburn, AlabamaAges 6–17 - NCT07105943Recruiting
Exercise intensity study for heart attack recovery
This trial is testing different ways of doing exercise during cardiac rehab to see which helps people feel better and stay active. It's for people who have had a heart attack or similar event in the last year and are considered low risk.
LeiriaAges 18 years+ - NCT07080567RecruitingPhase 2
Testing maraviroc for arm recovery after stroke
This study tests whether the drug maraviroc can help people who recently had a stroke recover arm movement faster. You may be eligible if your stroke was within the last 7 days and your arm is weak but you can still wiggle your fingers.
GenevaAges 18 years+ - NCT04609709Recruiting
Physical therapy plus electrical dry needling for tension headaches
This trial tests whether specific physical therapy treatments—exercise, manual soft-tissue work, mobilization, and electrical dry needling/TENS—can reduce tension-type headaches. It may help if your headaches happen often and fit the trial’s “frequent” or “chronic” pattern.
Fort Wayne, IndianaAges 18–65 - NCT06996652RecruitingPhase 2
Study of adalimumab to delay Parkinson's symptoms in sleep disorder
This trial tests whether adalimumab, an immune system drug, helps people with REM sleep behavior disorder (a condition that may warn of Parkinson's disease) stay healthy longer. Participants will receive injections of the drug or a placebo to see if it prevents Parkinson's-related brain problems.
Los Angeles, CaliforniaAges 50–80 - NCT06965920Enrolling by invitation
Spinal pain and balance study using gentle chiropractic care
This study tests a gentle chiropractic technique called flexion distraction to see if it improves how well you move and balance while standing. It may help if you have spinal pain and can stand with mild to moderate pain.
West Palm Beach, FloridaAges 18–100 - NCT06852521Enrolling by invitation
Understanding how we see visual features
This trial tests a theory about how our brains process visual features like color and shape. You'll likely do simple tasks on a computer screen while researchers measure your responses.
Santa Barbara, CaliforniaAges 18–55 - NCT06826300Enrolling by invitation
Elbow treatment study for archers and kart drivers
This study tests a special elbow technique on healthy 18-year-old archers who also race go-karts. It looks at how the elbow treatment might affect performance.
GdanskAges 18 years+ - NCT06821178Recruiting
My life and my experiences study for teens
This study looks at the life experiences of teenagers ages 12 to 18, comparing those who have had contact with social services or dependency court with those who have always lived with a parent. It helps researchers understand how different backgrounds affect well-being.
Irvine, CaliforniaAges 12–18 - NCT06818175Recruiting
Study of back muscle tissue and treatment for low back pain
This study looks at the tissue in your lower back using ultrasound and physical exams. It tests a treatment to see if it helps people with new or long-term low back pain, and also compares results to people without pain.
Blacksburg, VirginiaAges 18–50 - NCT06816329Recruiting
Stress and depression risk study for teenage girls
This study looks at how stress affects teenage girls who may be at higher risk for depression due to a parent's history. It involves MRI scans and daily surveys on a cell phone.
Belmont, MassachusettsAges 13–15 - NCT06492109Recruiting
Blood study on sleep loss
This study looks at blood samples to understand how sleep loss affects the body. It may help find new ways to diagnose or treat sleep problems.
Hangzhou, ZhejiangAges 18–80 - NCT05848895Recruiting
Osteopathy treatment for infants with positional head shape
This study tests an osteopathic manual therapy plan (hands-on treatment) for babies with positional plagiocephaly, aiming to improve head shape and comfort. It also asks families to attend multiple treatment and measurement visits so researchers can track change over time.
San Diego, CaliforniaAges 1 day–4 months - NCT06605014Recruiting
Body alignment after stroke or mini-stroke
This study looks at how a stroke or mini-stroke affects the body's natural movement and alignment (called somatic dysfunction). Researchers want to see if there are common patterns of tightness or imbalance after a stroke, which could help guide future treatments.
Sacramento, CaliforniaAges 18 years+ - NCT06590116Recruiting
Spinal manipulation for chronic low back pain
This study looks at how people feel about spinal manipulation therapy for long-term low back pain. It's for adults who have had pain in their lower back for more than three months and want to share their views on this type of treatment.
Gainesville, FloridaAges 18–70 - NCT06571877Enrolling by invitation
Bed rest study: how energy density affects eating
This study looks at how the amount of energy in food affects how much people eat when they are on bed rest. Healthy volunteers will stay in bed for a period of time, and researchers will measure their food intake to understand the relationship between energy density and appetite.
Tübingen, Baden-WurttembergAges 18–99 - NCT06533345Recruiting
Pain-free research for chronic pain
This trial studies a collaborative approach to help people with chronic pain, which is pain that lasts beyond a recent injury. It may be a good fit if you're not currently seeking medication for your pain.
Auburn, AlabamaAges 21–80 - NCT06516575Recruiting
Listening effort in cochlear implant users
This study measures how much effort it takes to listen and understand speech for adults with cochlear implants compared to those with normal hearing. It can help researchers learn how to improve hearing outcomes.
Minneapolis, MinnesotaAges 18–75
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Common questions
- Are there clinical trials for manipulation?
- Yes. Clin2 currently lists 91 recruiting manipulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a manipulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a manipulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.