Clinical trials
Mastocytosis clinical trials
Below are recruiting mastocytosis clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07142473Recruiting
Mastocytosis Registry from Childhood to Adulthood
This registry collects information from people with mastocytosis (a condition where too many mast cells build up in the skin or organs) who are treated at a specific clinic in Italy. The goal is to better understand how the disease changes over time from childhood to adulthood.
Pavia, PaviaAges 6 years+ - NCT04910685RecruitingPhase 2/Phase 3
BLU-263 for indolent mast cell disease with symptom control
This trial tests BLU-263, a study medicine, against placebo (inactive treatment) to see if it improves symptoms in people with indolent systemic mastocytosis. It also checks safety and how well the dose is tolerated before and during treatment.
Birmingham, AlabamaAges 18 years+ - NCT04996875RecruitingPhase 2
Bezuclastinib for advanced mast cell disease
This Phase 2 study tests bezuclastinib, a targeted medicine, in people with advanced systemic mastocytosis (including certain advanced forms with blood cancers). It aims to shrink measurable disease and improve symptoms, while helping people who may also need treatment for an associated blood cancer.
Birmingham, AlabamaAges 18 years+ - NCT06210698Recruiting
Angioedema biomarker research study
This study collects blood samples (and optional skin samples) from people with angioedema to learn more about the condition and find better ways to diagnose and treat it. If you join, you may help scientists understand angioedema better.
Wheaton, MarylandAges 12–75 - NCT07264959Recruiting
A study on indolent systemic mastocytosis treatments
This study is observing adults with indolent systemic mastocytosis (ISM) who are already receiving or planning to start symptom treatments or the drug avapritinib. It aims to learn more about how these treatments work in real life.
Wheaton, MarylandAges 18 years+ - NCT06440148Recruiting
Sclerostin and bone lesions in mastocytosis
This study explores how a protein called sclerostin relates to bone problems in people with mastocytosis. By understanding this link, researchers hope to improve bone health for patients with this rare condition.
Lublin, Lublin VoivodeshipAges 18 years+ - NCT06466889Recruiting
Mastocytosis Registry of Zurich
This study is a registry (a simple data collection) for people with mastocytosis or hypertryptasemia who are treated at the University Hospital of Zurich. It aims to gather information to better understand these conditions and improve care.
ZurichAges Any age - NCT07255638Recruiting
Study of avapritinib for indolent systemic mastocytosis
This study looks at how avapritinib works in people with indolent systemic mastocytosis whose symptoms are not well controlled by other treatments. You will take the drug as part of your usual care, and researchers will collect information to see how well it helps.
BerlinAges 18 years+ - NCT07562542Recruiting
Blood test study for mastocytosis mutation detection
This study looks for a specific genetic change (KIT-D816V mutation) in the blood of adults with mast cell disorders—conditions where immune cells called mast cells cause allergic-like reactions. Understanding this mutation may help doctors better diagnose and treat your condition.
Suzhou, JiangsuAges 18 years+ - NCT00044122Recruiting
Study of mast cell growth in people with mastocytosis
This study looks at what causes mast cells to grow too much in people with mastocytosis. It may help researchers find better ways to diagnose or treat this condition. You can take part in person or by telehealth.
Bethesda, MarylandAges 1 day–80 years - NCT06327685RecruitingPhase 1
Avapritinib and Decitabine for SM-AHN
This trial tests a combination of two drugs, avapritinib and decitabine, for people with systemic mastocytosis plus another blood cancer (SM-AHN). The goal is to see if the combination works better than either drug alone.
Phoenix, ArizonaAges 18 years+ - NCT06573723Recruiting
Rare disease registry at Hospital Italiano
This study collects information from patients with certain rare diseases to better understand them. If you have one of these conditions and receive care at Hospital Italiano de Buenos Aires, you may be able to join.
Buenos Aires, Buenos AiresAges Any age - NCT06748001RecruitingPhase 4
Avapritinib follow-up study for previous trial participants
This study provides continued access to avapritinib for people who have already been in a Blueprint Medicines trial and are still benefiting from the drug. It allows you to keep receiving treatment while staying monitored for safety.
EdegemAges Any age - NCT07328178Recruiting
Understanding IgE proteins in allergies and immune conditions
This study looks at IgE, a protein involved in allergic reactions, to better understand its role in different immune-related diseases. It aims to find out how different forms of IgE relate to health and disease, which may help improve diagnosis or treatment.
Leuven, Vlaams-BrabantAges 18 years+ - NCT02760238Recruiting
Myeloproliferative Neoplasms patient registry study
This is a research registry for people who have certain blood cancers called myeloproliferative neoplasms (MPNs). It helps researchers learn about the disease over time and may help future studies find and compare patients.
Toronto, OntarioAges Any age
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Common questions
- Are there clinical trials for mastocytosis?
- Yes. Clin2 currently lists 15 recruiting mastocytosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mastocytosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mastocytosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.